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Biocomposite ceramic scaffold with controllable degradation performance and strength and preparation method thereof

A technology of composite ceramics and bioceramics, applied in the direction of additive processing, etc., can solve the problems of bone scaffolds that are difficult to form and degrade, and the mechanical properties cannot be well integrated, so as to achieve excellent overall stability and spatial arrangement diversity, improve forming accuracy and The effect of success rate and uniform force

Active Publication Date: 2021-08-03
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above defects or improvement needs of the prior art, the present invention provides a biocomposite ceramic scaffold with controllable degradation performance and strength and its preparation method. And the formation of ceramic scaffolds with specific shapes, and by compounding three-phase ceramics, by adjusting components, proportions, structures, sintering processes, etc. to prepare composite ceramic scaffolds with controllable degradation, thus solving the problem that bone scaffolds are difficult to form and degrade using traditional techniques , The technical problem that the mechanical properties cannot be well integrated

Method used

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  • Biocomposite ceramic scaffold with controllable degradation performance and strength and preparation method thereof
  • Biocomposite ceramic scaffold with controllable degradation performance and strength and preparation method thereof
  • Biocomposite ceramic scaffold with controllable degradation performance and strength and preparation method thereof

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preparation example Construction

[0046] (2) Preparation of slurry solvent:

[0047] Mix a variety of photocurable resin monomers or prepolymers in a certain proportion, add plasticizer polyethylene glycol, and then add powder mass (2%-6%)m dispersant, ultrasonic vibration for 1-2 minutes, and then Add photoinitiator, polymerization inhibitor, release agent and lubricant, and stir evenly in a planetary vacuum rotary mixer at a speed of 2000-2900r / min, so that the photoinitiator and polymerization inhibitor are fully mixed to obtain a solvent;

[0048] S2. Preparation of light-cured three-phase ceramic slurry:

[0049] S21. First set the mass as m 1 Add the hydroxyapatite powder into the solvent, put it into a vacuum planetary mixer and stir evenly at a speed of 2000-2900r / min, take it out and add a mass of m 2 The β-tricalcium phosphate powder is stirred evenly at a speed of 2000-2900r / min, and then added with a mass of m 3 The micron-sized biological glass powder is stirred evenly at a speed of 2000-2900r / ...

Embodiment 1

[0073] 1. Use Magics 3D modeling software to design minimal curved surface lattice structures with porosities of 33%, 50%, and 66% through operations such as arrays. Change the hole size between 200-600 µm.

[0074] 2. Put the bio-glass powder in a ball mill with a ball-to-material ratio of 10:1 and mill at 450r / min for 5 hours, take it out and sieve it.

[0075] 3. Prepare bioceramic solvent: weigh 1,6-hexanediol diacrylate (HDDA), tripropylene glycol diacrylate (TPGDA) and polyethylene glycol 200, the total mass is 34.1g, stir with a glass rod Ultrasonic for 1-2 minutes after homogeneity, then add 1% of powder mass release agent rad2500 and 0.5% resin mass of photoinitiator TPO. The polymerization inhibitor p-hydroxyanisole that accounts for 0.1% of resin quality. Place in a planetary vacuum defoaming mixer and stir at 1000r / min for 10s, then at 2900r / min for 10 minutes, and finally at 1000r / min for 10s. Mix the photoinitiator evenly.

[0076] 4. Preparation of biocerami...

Embodiment 2

[0081] 1. Use the K3dsurf software to export the obj format of the minimal surface, put it into the Magics 3D modeling software to thicken it, and convert it into a solid to realize another minimal surface model establishment.

[0082] 2. Same as step 2 in implementation example 1.

[0083] 3. Prepare bioceramic solvent: weigh 1,6-hexanediol diacrylate (HDDA), tripropylene glycol diacrylate (TPGDA) and polyethylene glycol 200, with a total mass of 18g, and stir evenly with a glass rod After ultrasonication for 1-2 minutes, add 1% powder mass release agent rad2500 and 0.5% resin mass photoinitiator TPO. The polymerization inhibitor p-hydroxyanisole that accounts for 0.2% of resin mass. Place in a planetary vacuum defoaming mixer and stir at 1000r / min for 10s, then at 2900r / min for 10 minutes, and finally at 1000r / min for 10s. Mix the photoinitiator evenly.

[0084] 4. Preparation of bioceramic slurry: take by weighing 40g of bioceramic powder total mass, wherein bioglass acc...

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Abstract

The invention belongs to the field of biomedical materials and additive manufacturing, and relates to a biocomposite ceramic support with controllable degradation performance and strength and a preparation method thereof. The method includes: S1. taking hydroxyapatite powder, β-calcium phosphate powder and Micron-sized biological glass powder with a total mass of m; after mixing different kinds of photocurable resin monomers and / or their prepolymers in a predetermined ratio, adding a plasticizer and a dispersant for ultrasonic mixing, and then adding a photoinitiator and a photoresist Coagulant, release agent and lubricant, fully mixed to obtain a solvent; S2. Add the three powders to the solvent for stirring and vacuum ball milling to obtain a printing slurry; S3. Use the printing slurry for DLP 3D printing and / or optical printing Solidify to obtain a bioceramic green body; S4. Degrease and sinter the bioceramic green body to obtain a finished biocomposite ceramic stent. The invention can obtain composite bioceramics with excellent mechanical properties and degradation properties, and can be applied to bone tissue engineering technology.

Description

technical field [0001] The invention belongs to the field of biomedical materials and additive manufacturing, and relates to a biocomposite ceramic support with controllable degradation performance and strength and a preparation method thereof, more specifically, to a biodegradable scaffold based on photocuring to form a complex porous lattice structure. Biocomposite ceramic support and its preparation method. Background technique [0002] my country's aging population, frequent traffic accidents, bone tumors and other diseases caused human bone tissue defects, bone loss, fractures and bone diseases such as osteoporosis have aroused great concern. Orthopedic diseases have a high disability rate, leading to a decline in the quality of life of patients and even loss of labor force. Patients often require implant surgery to restore impaired function. The degradable implants currently used in clinical practice do not have complex and fine bionic structures and personalized sha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B35/447C04B35/622B33Y70/10B33Y80/00B33Y10/00
CPCB33Y70/00B33Y80/00C04B35/447C04B35/622C04B2235/36C04B2235/6562C04B2235/6565C04B2235/6567
Inventor 史玉升肖骏苏瑾化帅斌程立金吴甲民齐大虎朱皓
Owner HUAZHONG UNIV OF SCI & TECH
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