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A preparation method of a shape-memory polymer material with drug release function, and the resulting product and application

A technology of polymer materials and drugs, applied in the field of preparation of shape memory polymer materials, can solve the problems of mechanical strength and modulus decline, easy aggregation and precipitation of drugs, uncontrollable drug loading, etc., and achieve fast curing speed, stability and Sustained drug release effect, the effect of convenient control of the dissolved amount

Active Publication Date: 2022-05-31
LINYI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problems existing in the prior art, the present invention provides a preparation method of a shape-memory polymer material with drug release function and the product obtained. The operation steps of the method are simple, convenient and time-saving. High, uniform drug distribution, strong controllability of drug release, high modulus, high mechanical strength, fast recovery speed and large recovery stress, which solves the problem of drug release function produced by the current swelling method The existing shape memory polymer materials have problems such as cumbersome process, time-consuming, uncontrollable drug loading, easy aggregation and precipitation of drugs, and decrease in mechanical strength and modulus of materials after drug loading.

Method used

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  • A preparation method of a shape-memory polymer material with drug release function, and the resulting product and application
  • A preparation method of a shape-memory polymer material with drug release function, and the resulting product and application
  • A preparation method of a shape-memory polymer material with drug release function, and the resulting product and application

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Experimental program
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Effect test

Embodiment 1

[0072] 1. Polyethylene glycol-polycaprolactone-polyethylene glycol triblock copolymer (PEG) functionalized with 152.45 mmol terminal acrylate groups 2500 -PCL 4000 -PEG 2500 ) and 0.1 g of enoxacin were dissolved in 18 ml of deionized water, and ultrasonically dispersed for 60 min, so that the triblock copolymer formed nanomicelles, and all the drugs were dissolved in the micelles.

[0073] 2. After completely dissolving, add 3.25g hydroxyethyl acrylate, 1.89g acrylic acid and 0.064g photoinitiator 2,2-dimethoxy-2-phenylacetophenone. Nitrogen gas was bubbled for 20 minutes to remove dissolved oxygen, and the mixed solution was slowly injected into the glass mold with a disposable syringe, and multiple molds injected with the reaction mixed solution were placed under an ultraviolet device for photocrosslinking reaction, wherein the ultraviolet light intensity was 10mW / cm 2 . Illuminate for 20 minutes before and after the mold. After the reaction is over, take the cross-lin...

Embodiment 2

[0083] 1, with embodiment 1.

[0084] 2. After it is completely dissolved, add 3.25g of hydroxyethyl acrylate, 1.89g of acrylic acid and 0.064g of potassium persulfate. Nitrogen gas was bubbled for 20 minutes to remove dissolved oxygen, and the mixed solution was slowly injected into glass molds with a disposable syringe, and multiple molds injected with the reaction mixed solution were placed in an oven, and reacted at a temperature of 45°C for 12 hours. After the reaction is over, the crosslinked polymer material is taken out from the mold and placed on a polytetrafluoroethylene film, dried in an oven at 60°C for 12 hours, and then the temperature is raised to 80°C for 12 hours in vacuum to obtain the described A shape-memory polymer material, which is a temperature-responsive or water-responsive shape-memory polymer material.

Embodiment 3

[0086] 1, with embodiment 1.

[0087] 2. After it is completely dissolved, add 1.2g methacrylic acid, 0.994g acrylamide, 2.94g N-isopropylacrylamide and 0.064g photoinitiator 2,2-dimethoxy-2-phenylphenethyl ketone. Nitrogen gas was bubbled for 20 minutes to remove dissolved oxygen, and the mixed solution was slowly injected into the glass mold with a disposable syringe, and multiple molds injected with the reaction mixed solution were placed under an ultraviolet device for photocrosslinking reaction, wherein the ultraviolet light intensity was 10mW / cm 2 . Illuminate for 20 minutes before and after the mold. After the reaction is over, take the cross-linked polymer material out of the mold and place it on a polytetrafluoroethylene film, dry it in an oven at 60°C for 12 hours, and then raise the temperature to 80°C under vacuum. Dry for 12 hours to obtain the shape-memory polymer material, which is a temperature-responsive or water-responsive shape-memory polymer material. ...

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Abstract

The invention discloses a preparation method of a shape-memory polymer material with drug release function and the resulting product and application. The steps are: (1) dispersing an amphiphilic tri-block copolymer with a terminal double bond functionalized and a drug into the solvent to form nanomicelles or nanoreverse micelles under the action of similar miscibility, and the drug is encapsulated in nanomicelles or nanoreverse micelles; (2) Add monomers and The initiator is used to form a shape memory polymer material with drug release function through in situ free radical polymerization. The method is simple, convenient and time-saving, and the obtained product has high drug loading, uniform drug distribution, strong controllability of drug release, high modulus, high mechanical strength, fast recovery speed and The large recovery stress solves many shortcomings of the shape-memory polymer materials with drug release function prepared by the current swelling method.

Description

technical field [0001] The present invention relates to a preparation method of a shape-memory polymer material with drug release function and the resulting product and application, in particular to a preparation of a shape-memory polymer material with drug release control, degradability, high resilience and rapid response The method and the obtained product and application belong to the technical field of medical functional polymer materials. Background technique [0002] Shape memory polymers (also known as shape memory polymers) are those that can perceive the stimuli of changes in the external environment and respond to such changes, adjust their state parameters (such as shape, position, strain, etc.) to return to a preset state a class of polymer materials. Because of its good flexibility, large recoverable deformation, diverse stimulation methods, easy adjustment of response temperature, light weight, biodegradability, good biocompatibility, cheap price and easy proc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F287/00C08F220/20C08F220/06C08F220/56C08F220/54C08F220/14A61K47/34A61L27/18A61L31/06
CPCC08F287/00A61K47/34A61L27/18A61L31/06C08F220/20C08F220/06C08F220/56C08F220/54C08F220/14
Inventor 李兴建
Owner LINYI UNIVERSITY
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