Traditional Chinese medicine film spraying agent for promoting blood circulation, stopping bleeding, removing necrotic tissues and promoting tissue regeneration, and preparation method of traditional Chinese medicine film spraying agent

A technology that removes putrefaction, promotes muscle growth, activates blood and stops bleeding. It is applied in medical formulas, non-central analgesics, and medical preparations with non-active ingredients. It can solve problems such as easy moisture absorption and deterioration, waste of drugs, and inconvenient storage.

Pending Publication Date: 2020-01-14
XIAN CHIHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Powders have disadvantages such as slow absorption, particles that cannot be absorbed, and even aggravate inflammatory reactions, induce granuloma-like lesions, and are inconvenient to use, waste drugs, easy to absorb moisture and deteriorate, and are not easy to store.
Oral pills, tablets, capsules, etc. are not as effective as other dosage forms because they do not directly reach the damaged site

Method used

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  • Traditional Chinese medicine film spraying agent for promoting blood circulation, stopping bleeding, removing necrotic tissues and promoting tissue regeneration, and preparation method of traditional Chinese medicine film spraying agent
  • Traditional Chinese medicine film spraying agent for promoting blood circulation, stopping bleeding, removing necrotic tissues and promoting tissue regeneration, and preparation method of traditional Chinese medicine film spraying agent
  • Traditional Chinese medicine film spraying agent for promoting blood circulation, stopping bleeding, removing necrotic tissues and promoting tissue regeneration, and preparation method of traditional Chinese medicine film spraying agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: formulation formability experiment

[0050] 1. Pre-screening experiment of spray film formulation

[0051] With reference to the pre-experiment, directly select the concentrated solution of the whole extract of medicinal material components for testing, and finally determine the selection of the following prescriptions for testing, and use the conventional configuration method of film spraying agent for research. The prescription of pharmaceutical preparations is as follows:

[0052] Table 1 Prescription screening experiment

[0053]

[0054] The preparation process is as follows:

[0055] (1) Take 65g of rhubarb, 50g of coptis, 50g of notoginseng, 31g of Angelica dahurica, 31g of vinegar myrrh, and 12g of dragon's blood and mix them, add 8 times the amount of 80% ethanol to infiltrate for 45 minutes; heat the infiltrated mixture to reflux twice, For 1.5 hours each time, combine the alcohol extracts, filter, and use the filtrate for later use; add 8 t...

Embodiment 2

[0084] Prescription of traditional Chinese medicine spray film agent: rhubarb 25g, coptis 20g, panax notoginseng 20g, angelica dahurica 10g, donkey-hide gelatin 20g, calcined keel 18g, bletilla 18g, vinegar myrrh 10g, madder 20g, octopus 20g, dragon's blood 5g, licorice 2.5 g, pearl 1.5g, borneol 2g, chitosan derivative 12g, polyvinylpyrrolidone 40g, hydroxypropyl methylcellulose 3g, poloxamer 70g, plasticizer glycerin 20g, preservative 1g, 95% ethanol 250ml , to make 1000ml.

[0085] Preparation Process:

[0086] (1) Mix rhubarb, coptis, notoginseng and Angelica dahurica, add 5 times the amount of 70% ethanol to infiltrate for 45 minutes; heat the infiltrated mixture to reflux twice, each time for 1.5 hours, combine the alcohol extracts, and pass through 200 mesh stainless steel Filter through a net, and the filtrate is set aside; add 8 times the amount of water to the alcohol-extracted medicinal residues, cuttlebone, calcined keel, madder, and licorice, decoct twice for 1 h...

Embodiment 3

[0090] Prescription of traditional Chinese medicine spray film agent: rhubarb 35g, coptis 30g, notoginseng 30g, angelica dahurica 20g, donkey-hide gelatin 30g, calcined keel 28g, bletilla 28g, vinegar myrrh 20g, madder 30g, sea octopus 30g, dragon's blood 8g, licorice 10g , pearl 2.5g, borneol 5g, chitosan derivative 25g, polyvinylpyrrolidone 50g, hydroxypropyl methylcellulose 6g, poloxamer 80g, plasticizer glycerin 40g, fragrance eucalyptus oil 10g, preservative 3g , 400ml of 95% ethanol to make 1000ml.

[0091] Preparation Process:

[0092] (1) Mix rhubarb, coptis, notoginseng and Angelica dahurica, add 10 times the amount of 85% ethanol to infiltrate for 60 minutes; heat the infiltrated mixture to reflux twice, each time for 3 hours, combine the alcohol extracts, and pass through 200 mesh stainless steel Filter through a net, and the filtrate is set aside; add 10 times the amount of water to the alcohol-extracted medicinal residues, cuttlebone, calcined keel, madder, and l...

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Abstract

The present invention relates to a traditional Chinese medicine film spraying agent for promoting blood circulation, stopping bleeding, removing necrotic tissues and promoting tissue regeneration. Thetraditional Chinese medicine film spraying agent is prepared from the following components in 1,000 ml: Chinese rhubarb, coptis root, pseudo-ginseng, radix angelicae, donkey-hide gelatin, rhizoma bletillae, vinegar myrrh, radix rubiae, resina draconis, liquorice, pearl, borneol, a film forming material, a plasticizer, an aromatic, a preservative and 95% ethanol. Zhikang capsule is creatively improved into an external spraying film dosage form, during use, a spraying head of a spraying bottle is aimed at affected parts of traumatic injury for spraying, sprayed liquid medicine is quickly formedinto a film, so that effective components of the medicines are favorably soaked into the affected parts to generate a biochemical reaction, the medicines are not liable to lose, and a better treatment effect is generated; and the film spraying agent has obvious effects of promoting blood circulation, stopping bleeding, relieving swelling and pains, removing necrotic tissues, promoting tissue regeneration, inhibiting micro-organisms and diminishing inflammation, simultaneously is free of any hormone medicines, has advantages of high safety and low side effect, simultaneously sprays the liquidmedicine to form the film quickly, the effective components of the medicines are not liable to lose, and the better treatment effect is generated.

Description

technical field [0001] The invention belongs to the technical field of film-spraying agents, and in particular relates to a traditional Chinese medicine film-spraying agent for promoting blood circulation, stopping bleeding, removing putrefaction and promoting muscle growth and a preparation method thereof. Background technique [0002] With the development of society, the continuous improvement of material life makes people's pursuit of health more and more urgent, especially the fast-paced lifestyle in the city, so that more people understand that life lies in exercise, and scientific exercise is good for health. In the spare time of life, people use various ways to have and maintain a healthy body, such as running, playing ball, swimming, dancing swords, or fighting, etc. These sports also allow people to personally feel the benefits brought by music sports. The charm of life, such as making life full of sunshine, youth, physical and mental pleasure, physical health and s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/70A61K9/12A61K47/38A61K47/10A61K47/32A61K47/36A61P29/00A61K35/618A61K31/045A61K35/36A61K35/02
CPCA61K9/0014A61K9/7015A61K31/045A61K35/02A61K35/36A61K35/618A61K36/232A61K36/258A61K36/328A61K36/484A61K36/708A61K36/718A61K36/74A61K36/896A61K36/898A61K47/10A61K47/32A61K47/36A61K47/38A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61P29/00A61K2300/00
Inventor 张焕娣胡小虎张琼谭祥和吕慧锋
Owner XIAN CHIHO PHARMA
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