Pulsed electric field tumour ablation parameter optimization system

A pulsed electric field and pulsed voltage technology, applied in the field of pulsed electric field tumor ablation parameter optimization system, can solve problems such as differences in electrical response effects and treatment effects, and achieve the effects of less thermal damage, most thermal damage, and less damage

Active Publication Date: 2020-02-07
HANGZHOU WKNIFE MEDICAL TECH CO LTD
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  • Application Information

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Problems solved by technology

A large number of studies have shown that the dielectric properties of the same type of tumor in different patients, tumors in different parts of the same patient, and even different development stages of the same tumor tissue are significantly different, and the electrical response effect under different pulse parameters (corresponding to the therapeutic effect ) have a significant difference

Method used

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  • Pulsed electric field tumour ablation parameter optimization system
  • Pulsed electric field tumour ablation parameter optimization system
  • Pulsed electric field tumour ablation parameter optimization system

Examples

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Effect test

Embodiment 1

[0085] see Figure 1 to Figure 25 , a pulse electric field tumor ablation parameter optimization system, mainly includes an image processing module, a physical parameter measurement module, a pulse electrode parameter setting module, a pulse sequence formation module, several pulse electrodes and a database.

[0086] The database stores the data of the image processing module, the physical parameter measurement module, the pulse electrode parameter setting module and the pulse sequence forming module.

[0087] The image processing model acquires images of biological tissues of the user. The image processing model optimizes the image of the user's biological tissue to obtain the three-dimensional structure of the biological tissue, and determines the tumor tissue volume V in the three-dimensional structure T and location.

[0088] Further, the user's biological tissue image is a CT image or an MRI image.

[0089] Further, the biological tissue includes tumor tissue and norma...

Embodiment 2

[0139] The pulse electric field tumor ablation parameter optimization system, the main modules are the same as those described in Embodiment 1, and further the user's biological tissue image is a computerized tomography CT image or an MRI (magnetic resonance imaging) image.

[0140] CT images or MRI images can be processed by image segmentation and other methods to obtain the three-dimensional spatial structures of normal biological tissues, tumors, and arterial vessels, respectively, as follows: Figure 2 to Figure 4 shown. After the three-dimensional space structure is obtained, grid division and finite element calculation can also be performed on the three-dimensional space structure, such as Figure 5 shown.

[0141] Among them, the standard DICOM (Digital Imaging and Communications in Medicine) format is selected for the CT picture. The picture in this format contains relevant information during CT scanning, such as the scan interval and the pixel size of the picture, e...

Embodiment 4

[0143] Pulse electric field tumor ablation parameter optimization system, the main modules of the system are the same as those described in Example 1, further, the biological tissue includes tumor tissue and normal biological tissue. The biological tissue is liver.

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Abstract

The invention discloses a pulsed electric field tumour ablation parameter optimization system. The pulsed electric field tumour ablation parameter optimization system mainly comprises an image processing module, a physical parameter measuring module, a pulse electrode parameter setting module, a pulse sequence forming module, a plurality of pulse electrodes and a database, wherein the image processing model is used for obtaining biological tissue images of a user, and performing optimization processing on the biological tissue images of the user to obtain a three-dimensional structure of the biological tissue; the pulse electrode parameter setting module is used for processing received physical parameters, performing calculation to obtain pulse voltage, pulse number, pulse electrode position parameters and the depth that each pulse electrode is inserted into the biological tissue of the user, and transmitting the calculated pulse voltage, the calculated pulse number, the calculated pulse electrode position parameters and the calculated depth that each pulse electrode is inserted into the biological tissue of the user to the pulse sequence forming module; and the pulse electrodes can be used for performing pulse stimulation on the biological tissue of the user. According to the pulsed electric field tumour ablation parameter optimization system disclosed by the invention, optimal electrode arrangement and pulse parameters are arranged, so that the purposes that the tumor tissue is completely melted, and normal tissue damage and heat damage are minimum can be realized.

Description

technical field [0001] The invention relates to the application field of pulse electric field, in particular to a pulse electric field tumor ablation parameter optimization system. Background technique [0002] The report of the Global Cancer Survival Trend Monitoring Program (2000-2014) pointed out that the 5-year survival rate of most cancer patients in my country is lower than the world average, and the quality of life is poor, and the situation of cancer treatment is still not optimistic. The latest research has found that during the growth process of tumors, after multiple divisions and proliferations, their daughter cells have obvious differences in tumor growth speed, invasion ability, drug sensitivity, prognosis, etc. It shows a high degree of tumor heterogeneity, which reduces the efficacy of many traditional therapies. In recent years, gene and immune targeted therapies, which have emerged in recent years, instead promote the generation and development of tumor-res...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/12
CPCA61B18/1206A61B2018/00636
Inventor 姚陈果董守龙赵亚军余亮郑爽
Owner HANGZHOU WKNIFE MEDICAL TECH CO LTD
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