Self-driven manganese dioxide nanometer motor and preparation method and application thereof
A manganese dioxide, self-propelled technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. It can improve the hypoxic microenvironment of the tumor, enhance active penetration, and control the size of the tumor.
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Embodiment 1
[0056] A method for preparing a self-driven manganese dioxide nanomotor, comprising the steps of:
[0057] (1) Preparation of SiO 2 Nanoparticle dispersion: Take 25mL ethanol, 1.70mL ammonia water (concentration: 25wt%) and 0.5mL ultrapure water and mix evenly, and then carry out the first oil bath heating treatment under the stirring state with a rotation speed of 600 rpm, the first oil bath The temperature of the bath heating treatment was 40 °C, and the time of the first oil bath heating treatment was 30 min, then 1.5 mL of tetraethyl orthosilicate (TEOS) was added, and the treatment was stirred (600 rpm, 12 h). Pure water was alternately washed 4 times, and the last wash was ultrapure water to obtain SiO 2 nanoparticle dispersion, the SiO 2 In nanoparticle dispersion, SiO 2 The mass percent concentration of nanoparticles is 0.714wt%, and the SiO 2 The particle size of nanoparticles is 141.60nm;
[0058] (2) Dispense 1.4 mL of the SiO described in step (1) 2 The nanop...
Embodiment 2
[0075] Example 2 is basically the same as Example 1, except that the amount of paraffin added in step (2) is 0.1 g; other steps are the same as in Example 1.
[0076] Figure 8 For the embedded SiO prepared in Example 2 2 Scanning electron microscope image of nanoparticles of paraffin microspheres. from Figure 8 Part a) can be seen that the prepared paraffin microspheres are irregular spheres, after its surface is enlarged (such as Figure 8 as shown in part b)); from Figure 8 In part b), it can be clearly observed that silicon particles are distributed in a single layer on the paraffin surface, and some particles are embedded in the paraffin surface.
[0077] The SiO that embodiment 2 makes 2 @MnO 2 The Janus nanomotor also has a Janus structure, one side is a smooth silicon particle surface, and the other side is a rough manganese dioxide layer, which can be referred to Figure 5 or Figure 14 .
[0078] The self-driven manganese dioxide nanomotor that embodiment...
Embodiment 3
[0080] Example 3 is basically the same as Example 1, except that the amount of paraffin added in step (2) is 0.2 g; other steps are the same as in Example 1.
[0081] Figure 9 For the embedded SiO prepared in Example 3 2 Scanning electron microscope image of nanoparticles of paraffin microspheres. from Figure 9 Part a) can be seen that the prepared paraffin microspheres are irregular spheres, after its surface is enlarged (such as Figure 9 as shown in part b)); from Figure 9 In part b), it can be clearly observed that silicon particles are distributed in a single layer on the paraffin surface, and some particles are embedded in the paraffin surface.
[0082] The SiO that embodiment 3 makes 2 @MnO 2 The Janus nanomotor also has a Janus structure, one side is a smooth silicon particle surface, and the other side is a rough manganese dioxide layer, which can be referred to Figure 5 or Figure 14 .
[0083] The self-driven manganese dioxide nanomotor that embodiment...
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