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Preparation method of surface intelligent coating of orthopaedics temporary implant based on natural polysaccharide and product prepared from preparation method

A natural polysaccharide, intelligent coating technology, applied in coatings, prostheses, medical sciences, etc., can solve the problems of inability to control the adaptive release of antibiotics, poor compatibility of the implant surface, lack of high efficiency and practicability, etc. Effectively stabilize the antibacterial effect, avoid the easy dissolution of the structure, and reduce the effect of bacterial resistance

Active Publication Date: 2020-02-11
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method cannot regulate the adaptive release of antibiotics, and the graphene oxide used is potentially toxic, and layer-by-layer self-assembly lacks high efficiency and practicality.
[0007] As mentioned above, there are still some problems in the surface functionalization. The long-term existence of antibacterial agents induces bacterial resistance, bacteria are easy to colonize the surface, resulting in the failure of antibacterial agents, the surface compatibility of implants is poor, and the selected materials have certain toxicity, etc.

Method used

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  • Preparation method of surface intelligent coating of orthopaedics temporary implant based on natural polysaccharide and product prepared from preparation method
  • Preparation method of surface intelligent coating of orthopaedics temporary implant based on natural polysaccharide and product prepared from preparation method
  • Preparation method of surface intelligent coating of orthopaedics temporary implant based on natural polysaccharide and product prepared from preparation method

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Experimental program
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Effect test

Embodiment 1

[0037] (1) React 1 g of sodium alginate with 0.432 g of sodium periodate at 25°C for 24 hours, then dialyze with deionized water for 3 days, and freeze-dry to obtain the required formaldehyde sodium alginate with a degree of hydroformylation of 35%. ;

[0038] (2) Add 150mg of gelatin to the vial, add 3mL of water and heat to dissolve at 60°C to obtain solution 1, weigh 20mg of antibiotics and dissolve in 2mL of sodium carbonate solution with pH=10 to obtain solution 2, add solution 2 to solution 1 Mix evenly, and after mixing for a period of time, add 50 mg of alginate sodium alginate with a degree of hydroformylation of 35% to prepare a film-forming liquid;

[0039](3) Put the orthopedic temporary implant in the reactor, add the film-forming solution, and slowly volatilize the whole system at 40°C for 7 hours, and evenly wrap the composite film on the surface of the orthopedic temporary implant.

[0040] (4) Prepare a glutaraldehyde solution with a mass fraction of 2.5% wit...

Embodiment 2

[0044] (1) React 1 g of sodium alginate with 1.03 g of sodium periodate at 25°C for 24 hours, then dialyze with deionized water for 3 days, and freeze-dry to obtain the required formaldehyde sodium alginate with a degree of formylation of 56%. ;

[0045] (2) Add 150mg of gelatin to the vial, add 3mL of water and heat to dissolve at 60°C to obtain solution 1, weigh 20mg of antibiotics and dissolve in 2mL of sodium carbonate solution with pH=10 to obtain solution 2, add solution 2 to solution 1 and mix Evenly, after mixing for a period of time, add 50 mg of alginate sodium alginate with a degree of hydroformylation of 56% to prepare a film-forming solution;

[0046] (3) Put the orthopedic temporary implant in the reactor, add the film-forming solution, and slowly volatilize the whole system at 40°C for 7 hours, and evenly wrap the composite film on the surface of the orthopedic temporary implant.

[0047] (4) Prepare a glutaraldehyde solution with a mass fraction of 2.5% with w...

Embodiment 3

[0049] (1) React 1 g of sodium alginate with 1.5 g of sodium periodate at 25°C for 24 hours, then dialyze with deionized water for 3 days, and freeze-dry to obtain the desired alginate sodium alginate with a degree of hydroformylation of 81.3%. ;

[0050] (2) Add 150mg of gelatin to the vial, add 3mL of water and heat to dissolve at 60°C to obtain solution 1, weigh 20mg of antibiotics and dissolve in 2mL of sodium carbonate solution with pH=10 to obtain solution 2, add solution 2 to solution 1 and mix Evenly, after mixing for a period of time, add 50 mg of alginate sodium alginate with a degree of hydroformylation of 81.3% to prepare a film-forming solution;

[0051] (3) Put the orthopedic temporary implant in the reactor, add the film-forming solution, and slowly volatilize the whole system at 40°C for 7 hours, and evenly wrap the composite film on the surface of the orthopedic temporary implant.

[0052] (4) Prepare a glutaraldehyde solution with a mass fraction of 2.5% wit...

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Abstract

The invention discloses a preparation method of a surface intelligent coating of an orthopaedics temporary implant based on natural polysaccharide. The preparation method comprises the following stepsof (1) enabling a first kind of polysaccharide to react with sodium periodate to obtain hydroformylation polysaccharides of which the hydroformylation degree is 55%-65%; (2) dissolving strengthened polysaccharide in hot water to obtain a solution a, dissolving an antibiotic in a sodium carbonate solution of which the pH is 9-10 to obtain a solution b, adding the solution b to the solution a, performing uniform mixing, and adding the hydroformylation polysaccharide obtained in the step (1) so as to obtain a film forming solution; (3) putting an orthopaedics temporary implant to a reactor, adding the film forming solution obtained in the step (2), performing slow volatilization at 30-60 DEG C, and uniformly wrapping the surface of the orthopaedics temporary implant with an upper composite membrane; and (4) putting a material prepared in the step (3) into a solution to which a cross-linking agent is added, performing soaking for 5-20min, taking out the material, performing cleaning withwater, and performing baking so as to obtain the orthopaedics temporary implant with modified upper composite membrane. The product disclosed by the invention is excellent in antibacterial effects.

Description

technical field [0001] The invention belongs to the field of medical materials, and relates to a preparation method of a surface intelligent coating of a temporary orthopedic implant based on natural polysaccharides and a product thereof. Background technique [0002] Implant-related infections often occur clinically in orthopedics, mainly due to the two major problems of local bacterial reproduction and bacteremia. Orthopedic implant infection has the characteristics of high incidence, recurrent and delayed, which often leads to treatment failure and even endangers the health of patients. In order to solve the infection problem of orthopedic implants, many efforts have been made in surface functionalization. For example, building a cationic coating on the surface for contact sterilization. Among the bactericidal cationic polymers reported in the literature, polycations derived from quaternary ammonium compounds (QACs), polyethyleneimine derivatives, chitosan derivatives, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/54A61L27/50
CPCA61L27/34A61L27/54A61L27/50A61L2300/406A61L2300/606A61L2430/02C08L5/04C08L89/00Y02A50/30
Inventor 徐福建章露娇段顺
Owner BEIJING UNIV OF CHEM TECH