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Ultralinear degradable polymer hydrogel and preparation method thereof

A technology for degrading polymers and hydrogels, applied in the field of superlinear degradable polymer hydrogels and their preparation, can solve the problems of complexity, molecular hydrogels are not easily degraded, degradability and gel properties are not easily regulated, etc. Achieving the effect of high biocompatibility, rich types, and increased controlled release properties

Inactive Publication Date: 2015-12-16
JIUJIANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to enrich the types of hydrogels, broaden the application fields of hydrogels, overcome the shortcomings of the existing natural polymer hydrogel structure, degradability and gel characteristics, and the inadequacies of synthetic polymer hydrogels that are not easy to degrade, etc. To meet the demand for controlled release of drugs, bioactive ingredients and other functional ingredients, this invention introduces biodegradable polyester into hydrogel, and develops a new type of smart hydrogel—a super-linear degradable polymer hydrogel, The degradable polymer used in the hydrogel of the present invention has a high number of blocks and an ultra-long molecular chain, and the entanglement of the chains in the gel is more complicated, and the cross-linking between the gel particles is tighter, so the functional components The coating and release characteristics are more excellent, and the gel can be realized under the condition of low concentration, which has a wide range of application value in the field of biomedicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Purge the reactor with air condensing reflux device with high purity argon. Weigh 100g of double-ended hydroxy polyethylene glycol with a number average molecular weight of 2000, 130g of caprolactone, 50g of glycolide, 1g of zinc isooctanoate, and 1g of stannous octoate into the reactor; heat the reaction system to 150°C, Reaction for 30h; add 300mL of anhydrous and oxygen-free toluene into the reactor, stir well; after the reaction system is cooled to 60℃, add 0.03976mol toluene diisocyanate and 0.00542mol 3-isocyanate group-3,5,5-trimethyl Cyclohexyl isocyanate, 0.0033mol hexamethylene diisocyanate, and then reacted at 60°C for 6h, 80°C for 6h, and 100°C for 5h; after the above reaction system is cooled to 60°C, 400mL petroleum ether is added to it, and the upper liquid is removed after shaking ;Add 200mL petroleum ether, shake and remove the upper liquid; dry the above product under 5Pa vacuum condition and 100℃ temperature condition for 15h; add 1.8L phosphate buffer...

Embodiment 2

[0034] Purge the reactor with air condensing reflux device with high-purity nitrogen. Weigh 100g of double-terminated polyethylene glycol with a number average molecular weight of 1000, 100g of caprolactone, and 2g of zinc isooctanoate into the reactor; increase the temperature of the reaction system to 130°C and react for 20h; measure for anhydrous and oxygen-free treatment Add 200 mL of toluene into the reactor and stir evenly; after the reaction system is cooled to 60°C, add 0.09mol hexamethylene diisocyanate, and then react at 60°C for 6 hours, 80°C for 6 hours, and 100°C for 5 hours; the above reaction system is cooled to 60°C. After ℃, add 300mL petroleum ether, shake and remove the upper liquid; add 100mL petroleum ether, remove the upper liquid after shaking; dry the above product under 10Pa vacuum condition and 80℃ temperature condition for 20h; add to the product With 0.8L deionized water, an aqueous solution of superlinear degradable polymer is prepared by heating, s...

Embodiment 3

[0036] Purge the reactor with air condensing reflux device with high purity argon. Weigh 100g of double-terminated polyethylene glycol with a number average molecular weight of 1600, 150g of caprolactone, and 2g of stannous octoate into the reactor; increase the temperature of the reaction system to 130°C and react for 24h; measure for anhydrous and oxygen-free treatment Add 250mL of toluene into the reactor and stir evenly; after cooling the reaction system to 60℃, add 0.06035mol hexamethylene diisocyanate, and then react at 60℃ for 6h, 80℃ for 6h, and 100℃ for 5h; the above reaction system is cooled to 40℃ Then, add 300mL petroleum ether to it, shake and remove the upper liquid; add 100mL petroleum ether, remove the upper liquid after shaking; dry the above product under a vacuum of 100Pa and a temperature of 90°C for 30h; add 2L to the product Physiological saline is prepared by heating, shaking, cooling and other methods to prepare a solution of superlinear degradable polym...

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PUM

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Abstract

The invention relates to an ultralinear degradable polymer hydrogel and a preparation method thereof. The ultralinear degradable polymer hydrogel comprises main ingredients of hydrogel media and ultralinear degradable polymers in the mass ratio being (1.86:1)-(9:1). The ultralinear degradable polymers are multicomponent multi-block copolymers with the block number being 12-100. The preparation method comprises preparation of the ultralinear degradable polymers and preparation of the hydrogel. The prepared hydrogel takes biodegradable polyester as a main ingredient and can be degradable, a degradation product is non-toxic, and accordingly, the hydrogel has very high biocompatibility; meanwhile, the degradable polymers have high block number, ultralong molecular chains and diversified structures, entanglement of chains in the gel is more complicated, crosslinking of gel particles is tighter, and thus, the hydrogel has more excellent coating and release characteristics on functional components, can realize gelling under the low-concentration condition and has wide application value in the bio-medical field.

Description

Technical field [0001] The invention relates to a hydrogel and a preparation method thereof, belonging to the field of biomedical polymer material manufacturing and application, in particular to a superlinear degradable polymer hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a gel with water as the dispersion medium. It is a polymer network system, soft in nature, can maintain a certain shape, and can absorb a large amount of water. As a high water absorption and high water retention material, hydrogel is widely used in many fields, such as: drought resistance in arid areas, facial masks in cosmetics, antipyretic stickers, pain relief patches, agricultural films, and anti-condensation in construction Agent, humidity regulator, water shutoff regulator in petrochemical industry, dehydration of crude oil or refined oil, dust suppressant in mining, preservative and thickener in food, drug carrier in medical treatment, etc. According to the differ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08G18/48C08G63/664
Inventor 吴传保曾湘晖刘利江
Owner JIUJIANG UNIVERSITY
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