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Shapeable artificial bone composite material and preparation method thereof

A composite material and artificial bone technology, applied in the field of biomedical composite materials, can solve the problems of inflexibility, convenience, free plasticity, inconvenient use, and affecting bone growth

Active Publication Date: 2021-05-28
立心(深圳)医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, since the artificial bone material in Patent Document 1 needs to rely on water to obtain fluidity, it is easily washed away when injected in a clinical aqueous environment operation and cannot be used normally, while the material in Patent Document 2 is in the form of a blocky hard solid. It cannot be flexibly and conveniently freely plasticized, so it is inconvenient to use during surgery, and it is not easy to fill in the ingredients when filling bone defects and will leave a large number of gaps, which will affect bone growth

Method used

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  • Shapeable artificial bone composite material and preparation method thereof
  • Shapeable artificial bone composite material and preparation method thereof
  • Shapeable artificial bone composite material and preparation method thereof

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[0071] Such as figure 2 As shown, the preparation method of the plastic artificial bone composite material 1 involved in the present disclosure may include the following steps: preparing a degradable polymer material 11, and dissolving the polymer material 11 in an organic solvent to obtain a polymer solution ( Step S10); adding inorganic particles 12 composed of calcium and phosphorus compounds into the polymer solution and mixing to obtain a mixture solution (step S20); drying the mixture solution and drying it in a vacuum to obtain a polymer material 11 and inorganic particles 12. The average molecular weight of the polymer material 11 is 4000Da to 16000Da. In the artificial bone composite material 1, the inorganic particles 12 are distributed in the polymer material 11. The artificial bone composite material 1 In the form of moldable plasticine (step S30).

[0072] In the preparation method of the plastic artificial bone composite material 1 involved in this embodiment, ...

Embodiment 1】 to 【 Embodiment 16

[0092] Firstly, the monomers of each of Examples 1 to 16 were prepared. According to Table 1, the monomers of Examples 1 to 16 were prepared, and monomers having the average molecular weights and types shown in Table 1 were obtained. Next, the catalysts and initiators shown in Table 1 were respectively added to the monomers of Examples 1 to 16 to obtain a mixture containing the monomers. According to the reaction temperature and reaction time shown in Table 1, the mixture was heated to a predetermined reaction temperature and reacted for a predetermined time to obtain the degradable polymer materials of various examples from Example 1 to Example 16.

[0093] Next, take the degradable polymer material of each embodiment (embodiment 1 to embodiment 16), and prepare the sample solution of each embodiment (embodiment 1 to embodiment 16) according to the ratio of 0.2g polymer material plus 1ml tetrahydrofuran , then use tetrahydrofuran as mobile phase, and use polystyrene as the r...

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Abstract

The present disclosure provides a plastic artificial bone composite material and its preparation method, which is characterized in that it is a composition composed of a degradable polymer material and inorganic particles distributed in the polymer material, and the polymer material The average molecular weight of the artificial bone is 4000Da to 16000Da, the inorganic particles are composed of calcium and phosphorus compounds, and the artificial bone composite material is in the shape of plasticine. According to the present disclosure, a shapeable artificial bone composite material capable of free shaping and free injection and a preparation method thereof can be provided.

Description

technical field [0001] The disclosure belongs to the field of biomedical composite materials, in particular to a plastic artificial bone composite material and a preparation method thereof. Background technique [0002] Bone defect is a common disease, and various factors such as trauma, inflammation, bone disease, and surgery can cause bone tissue defect. The current method for repairing bone defects is to use artificial bone materials to repair them. Such artificial bone materials usually contain hydroxyapatite and other main inorganic components that make up human bones. [0003] The existing patent document 1 proposes an injectable artificial bone suspension and its preparation method. The artificial bone injection material is prepared by mixing hydroxyapatite, recombinant human bone morphogenetic protein-2, chitosan solution and heparin saline The disadvantage of this suspension is that the hydroxyapatite particles tend to precipitate in the liquid during storage, resu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/46A61L27/50
CPCA61L27/58A61L27/50A61L2400/06A61L2430/02A61L27/12A61L27/18C08L67/04
Inventor 孙杨向冬凡小山赵金忠蒋佳燕晓宇王立人
Owner 立心(深圳)医疗器械有限公司
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