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Method for preparing glucosamine sulfate and sodium chloride double salt

A technology of glucosamine sulfate and glucosamine hydrochloride, applied in the field of medicine and chemical industry, can solve the problems of instability, product instability, unsuitable for industrialized production, etc., and achieve the effects of low cost and simple process.

Active Publication Date: 2020-02-21
SHANDONG RUNDE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure glucosamine sulfate has very high hygroscopicity, which leads to unstable products and low content. It is unstable when made into general preparations, not suitable for medicinal use, and not suitable for large-scale industrial production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 1kg of chitin powder, add 2.5L of lactate glycine hydrochloride and 0.85L of hydrochloric acid with a mass concentration of 32%, stir and mix at 43℃, and then use a diaphragm pump to continuously pump into the microporous membrane filter for filtration. The filtrate; the obtained filtrate was heated to 68°C, kept warm and added dropwise hydrochloric acid with a mass concentration of 25%, stirred for 15 minutes, after cooling, added activated carbon for decolorization, concentrated, washed, and dried to obtain glucosamine hydrochloride; to the obtained glucosamine hydrochloride Add sodium carbonate aqueous solution, heat to 80℃, add acetone, cool to 35℃, stir for 0.5-1 hour, then add sulfuric acid whose volume is 1 times the mass concentration of sodium carbonate aqueous solution and 32%, and stir for 0.5-1 hour to make the material Fully react; cool the reacted materials to 10℃, crystallize under stirring conditions, and centrifuge to obtain white crystals; dry the c...

Embodiment 2

[0028] Take 1kg of chitin powder, add 3.0L lactate glycine hydrochloride and 1.0L hydrochloric acid with a mass concentration of 30% to it, stir and mix at 45℃, and then use a diaphragm pump to continuously pump into the microporous membrane filter for filtration. The filtrate; the obtained filtrate was heated to 70°C, kept warm and added dropwise hydrochloric acid with a mass concentration of 28%, stirred for 10 minutes, after cooling, added activated carbon for decolorization, concentrated, washed, and dried to obtain glucosamine hydrochloride; to the obtained glucosamine hydrochloride Add sodium carbonate aqueous solution, heat to 70°C, add acetone, cool to 30°C, stir for 0.5-1 hour, add sulfuric acid 1.5 times the volume of sodium carbonate aqueous solution and 20% mass concentration, and stir for 0.5-1 hour to make the material Fully react; cool the reacted materials to 5°C, crystallize under stirring conditions, and centrifuge to obtain white crystals; dry the centrifuged ...

Embodiment 3

[0030] Take 1kg of chitin powder, add 2.0L lactate glycine hydrochloride and 1L hydrochloric acid with a mass concentration of 35% to it, stir and mix at 40℃, and then use a diaphragm pump to continuously pump into the microporous membrane filter for filtration to obtain the filtrate The obtained filtrate was heated to 65°C, kept warm and added dropwise hydrochloric acid with a mass concentration of 23%, stirred for 17 min, after cooling, added activated carbon for decolorization, concentrated, washed, and dried to obtain glucosamine hydrochloride; added to the obtained glucosamine hydrochloride Sodium carbonate aqueous solution, heated to a temperature of 85°C, add acetone, cool to 45°C, stir for 0.5-1 hour, then add sulfuric acid with a volume of 1.3 times the sodium carbonate aqueous solution with a mass concentration of 24%, and stir for 0.5-1 hour to make the material full Reaction: Cool the reacted materials to 15°C, crystallize under stirring conditions, and centrifuge to...

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Abstract

The invention belongs to the field of pharmaceutical chemicals and discloses a method for preparing glucosamine sulfate and sodium chloride double salt. The preparation method comprises the followingsteps: adding lactic acid glycine hydrochloride and hydrochloric acid into chitin powder, performing stirring and mixing, and performing filtering to obtain filtrate; heating the filtrate, performinginsulation, dropwise adding hydrochloric acid into the solution, stirring the mixture, cooling the mixture, and performing decoloring, concentrating, washing and drying to obtain glucosamine hydrochloride; adding a sodium carbonate aqueous solution into the glucosamine hydrochloride, performing heating, adding acetone into the mixture, performing cooling and stirring, adding sulfuric acid into themixture, performing stirring, cooling completely reacted materials to 5-15 DEG C, performing crystallization, drying centrifuged crystals to obtain the glucosamine sulfate and sodium chloride doublesalt. The method has a safe and controllable production flow, the glucosamine sulfate and sodium chloride double salt has high purity and high stability, the finished product has high quality, and thedefects that pure glucosamine sulfate has high moisture absorption, is not stable and is not suitable for medicinal application can be overcome.

Description

Technical field [0001] The invention relates to the field of medicine and chemical engineering, in particular to a preparation method of glucosamine sulfate and sodium chloride double salt. Background technique [0002] Amino sugars are usually used as monosaccharide residues in complex oligosaccharides and polysaccharides. Glucosamine is an amino derivative of the monosaccharide glucose. Glucosamine can significantly relieve the pain of arthritis and rheumatism patients and improve, prevent, treat and repair connective tissue damage. It also has a certain effect on inflammation of bones and arthritis. It also helps the healing of acute and chronic inflammation. Disease and pneumonia also have a certain curative effect to inhibit the overgrowth of cancer cells or fibroblasts, and play an inhibitory and therapeutic effect on cancer and malignant tumors. [0003] Glucosamine in the prior art mainly consists of two types: glucosamine hydrochloride and glucosamine sulfate. In terms o...

Claims

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Application Information

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IPC IPC(8): C07H1/00C07H5/06C07H1/06
CPCC07H1/00C07H1/06C07H5/06
Inventor 卢健行卢建智姚珊珊吴祥舟卢建功
Owner SHANDONG RUNDE BIOTECH CO LTD
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