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Composite nanofiber elastic bandage and preparation method thereof

A composite nanofiber and elastic bandage technology, which is applied in the field of medical supplies, can solve the problems of easy displacement of bandages, unavoidable restraint, and reduced use effect, so as to promote wound healing, reduce the risk of adhesion, and avoid bandage displacement.

Active Publication Date: 2022-02-25
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional medical bandages mostly use multi-layer medical gauze. There are many problems with this bandage material. First, the air permeability is average; Stretching, restricting joint movement and the bandage will shift during the movement, greatly reducing the use effect. Finally, when the wound exudates a lot, it cannot absorb the exudate in time, and it is easy to adhere to the wound, causing secondary damage
[0003] Electrospinning technology is a general method for preparing nanofibers. The nanofibers prepared by this method have the characteristics of high porosity and large specific surface area. Applying it to bandages or wound dressings can improve the breathability of bandages to a certain extent. performance, but the tensile properties of conventional electrospun nanofiber membranes still cannot fully improve the elastic properties of the bandage, and cannot avoid the restraint of the joint movement of the wounded part, and the problem that the bandage is easy to shift and affect the use effect

Method used

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  • Composite nanofiber elastic bandage and preparation method thereof
  • Composite nanofiber elastic bandage and preparation method thereof
  • Composite nanofiber elastic bandage and preparation method thereof

Examples

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preparation example Construction

[0032]A preparation method for a composite nanofiber elastic bandage, comprising the following steps:

[0033] (1) Spinning solution configuration: hydrophilic natural polymer material A is dissolved in its solvent to obtain spinning solution A, hydrophilic natural polymer material B and active pharmaceutical ingredients are mixed and dissolved in its solvent to obtain spinning solution B , the hydrophobic polymer material is dissolved in its solvent to obtain a spinning solution C;

[0034] (2) Electrospinning device construction: the electrospinning device includes a high-voltage power supply, a liquid supply mechanism, a spinning nozzle and a collecting pole, and the positive and negative poles of the high-voltage power supply are respectively connected to the spinning nozzle and the collecting pole; extremely like figure 1 and figure 2 As shown, it includes a conductive layer, a first elastic film 2 and a second elastic film 3 that are stacked sequentially from bottom t...

Embodiment 1

[0056] A method for preparing a composite nanofiber elastic bandage, using the electrospinning device and process steps of the above-mentioned embodiment, its specific parameters are:

[0057]Described step (1) is: take by weighing 0.6g chitosan, 0.01g polyoxyethylene (PEO) and mix as hydrophilic natural macromolecular material A, add 6.8ml distilled water, stir 45min under normal temperature and make it dissolve in distilled water to obtain Spinning liquid A; Weigh 0.4g chitosan, 0.01g polyethylene oxide (PEO) and mix as hydrophilic natural polymer material B, add 0.3g astragalus polysaccharide as the active ingredient of medicine, add 6.0g alcohol and stir for 45min at room temperature Dissolve the hydrophilic natural polymer material B and astragalus polysaccharide in alcohol to obtain the spinning solution B; weigh 0.6g of thermoplastic polyurethane elastomer rubber (TPU) as the hydrophobic polymer material, add 4.4ml N, N-dimethyl formazan Amide solution, stirred at 40°C ...

Embodiment 2

[0065] A method for preparing a composite nanofiber elastic bandage, using the electrospinning device and process steps of the above-mentioned embodiment, its specific parameters are:

[0066] Described step (1) is: take by weighing 0.6g chitosan, 0.01g polyoxyethylene (PEO) and mix as hydrophilic natural macromolecular material A, add 6.8ml distilled water, stir 45min under normal temperature and make it dissolve in distilled water to obtain Spinning solution A; Weigh 0.36g sodium alginate and 0.01g polyethylene oxide (PEO) as hydrophilic natural polymer material B, dissolve sodium alginate in 7.4ml deionized water to form solution A, add polyethylene oxide 0.3g astragalus polysaccharide was dissolved in 6.0g alcohol to make solution B, solution A and solution B were mixed and stirred evenly at a volume ratio of 3:2, and 1.4g triton-100 and 0.05g dimethyl sulfoxide (DMSO ) mixed and stirred for 3 hours, and centrifugally defoamed to obtain spinning solution B; 0.6g thermoplas...

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Abstract

The invention discloses a composite nanofiber elastic bandage and a preparation method thereof. The bandage is prepared by an electrospinning device using a double-layer elastic film as a collector. The composite nanofiber elastic bandage is a three-layer composite nanofiber film with a double-fold structure , including a water-absorbing layer, a drug-loaded layer and a protective layer stacked from bottom to top. The bandage has good elastic properties and can expand and contract with the joint during joint movement, avoiding the restraint of the joint movement of the injured part and the displacement of the bandage. At the same time, it can ensure air permeability, promote wound healing, absorb wound exudate, and reduce the risk of wound adhesion.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to a composite nanofiber elastic bandage and a preparation method thereof. Background technique [0002] Medical bandages are medical accessories that can be placed on wounds. They can be applied to external wounds to help wounds heal and isolate the external environment. Traditional medical bandages mostly use multi-layer medical gauze. There are many problems with this bandage material. First, the air permeability is average; Stretching, restricting joint movement and the bandage will shift during the movement, greatly reducing the use effect. Finally, when the wound exudates a lot, it cannot absorb the exudate in time, and it is easy to adhere to the wound, causing secondary damage. [0003] Electrospinning technology is a general method for preparing nanofibers. The nanofibers prepared by this method have the characteristics of high porosity and large specific surface ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/28A61L15/42A61L15/44A61F13/02D01F9/00D01F8/18D01F6/70D01D5/00D04H1/4374D04H1/728
CPCA61L15/28A61L15/26A61L15/44A61L15/42A61F13/0276A61F13/0273D01F9/00D01F8/18D01F6/70D04H1/728D04H1/4374D01D5/0061D01D5/0076A61L2300/232A61L2300/412C08L5/08C08L71/02C08L75/04
Inventor 潘维于桂凤李鹏王娟张志广夏伟姜凤硕
Owner QINGDAO AGRI UNIV