Urinary catheter

A urinary catheter and hydrophilic technology, applied in catheters, coatings, pharmaceutical formulations, etc., can solve problems such as environmental pollution, cumbersome steps, poor uniformity and firmness, etc., to avoid environmental pollution, reduce the use of organic solvents, The effect of high lubricity

Active Publication Date: 2020-03-03
JIANGSU BIOSURF BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this method, the initiator and the monomer are polymerized by UV after soaking, and are coated on the surface of the urinary catheter, which has poor uniformity and firmness. This system also has the problem of environmental pollution, and the method steps are relatively cumbersome.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Step 1: Synthesis of water-soluble polymerizable photosensitive monomer

[0094] Weigh 22.4g (100mmol) 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, 10.6g (105mmol) triethylamine and dissolve in 100mL dichloromethane and place in a 250mL flask and placed in an ice-water bath to fully dissolve. 9.1 mL of bromoacetyl bromide (21.1 g, 105 mmol) in dichloromethane was slowly added dropwise to the flask, and the dropwise addition was completed within 1 h. After reacting for 0.5 h under ice-bath conditions, the reaction was continued for 10 h at room temperature. After the reaction was completed, cool to room temperature and dissolve the crude product in dichloromethane, wash twice with saturated brine, hydrochloric acid (1M) and saturated sodium bicarbonate successively, dry over anhydrous magnesium sulfate, filter and spin dry the solvent, wash with acetic acid Ethyl ester and n-hexane were used as eluents, and after purification by column chromatography, 28.8g of...

Embodiment 2

[0107] Change the material of the urinary catheter used in Step 4 of Example 1, and other steps are the same as in Example 1, and the lubrication performance is evaluated, and the results are shown in Table 1.

[0108] In addition, catheters of different materials were taken directly, the surface was wiped clean with dust-free paper dipped in 75% ethanol, and after drying, they were placed in a clip-type friction tester to test the lubrication performance. The results are shown in Table 1.

[0109] Table 1 Lubrication properties of catheters made of different materials

[0110]

[0111] It can be seen that the urinary catheter with the hydrophilic coating of the present invention can significantly reduce the friction force after 30 cycles, and the lubricating performance is more stable and durable. In addition, the lubricating performance of the polyvinyl chloride catheter is relatively the best, because the coating liquid has the best affinity with the PVC catheter, and th...

Embodiment 3

[0113] Change the reaction time of step 2 and the amount of initiator in Example 1 to obtain photocurable polymers with different molecular weights (the molecular weight in Table 2 is rounded up), and the other steps are the same as in Example 1, and the lubricating properties are evaluated , the results are shown in Table 2.

[0114] Table 2 The effect of photocurable polymer molecular weight on the performance of PVC catheter coating

[0115]

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Abstract

The invention relates to a urinary catheter, wherein at least the insertable part of the urinary catheter is coated with a hydrophilic lubricating coating, a coating material composition containing aphotocurable polymer is coated on the surface of the urinary and is cured through illumination to form the hydrophilic lubricating coating, and the photocurable polymer is formed by copolymerizing a water-soluble polymerizable photosensitive monomer with a specific structure and a hydrophilic monomer. The urinary catheter disclosed by the invention has advantages of good lubricating property, excellent biological safety and high firmness.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to the field of urinary catheters with a hydrophilic lubricating coating. Background technique [0002] Urinary catheter is a commonly used insertable medical device, which is widely used in patients with anesthesia surgery, postoperative bed rest recovery, inconvenient movement and inability to urinate independently, urination disorders, and difficulties. The materials of the urinary catheter mainly include latex, natural rubber, polyvinyl chloride, silicone rubber, etc. Since the surface of the urinary catheter made of these materials is not lubricated enough, there is a large resistance during the process of inserting or pulling out the urethra or the stoma site, which is easy to use. The tissue around the urethra and fistula is damaged and accompanied by strong pain. Therefore, it is necessary to lubricate the urinary catheter, reduce the resistance to the body during insertion a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D139/06C08J7/056C08F226/02C08F220/36A61L29/08A61L29/04A61L29/14C08L27/06
CPCA61L29/041A61L29/085A61L29/14A61L2400/18A61L2420/02C08F226/02C08J2327/06C08J2439/06C09D139/06C08L27/06C08F220/36
Inventor 雷杰华唐增超
Owner JIANGSU BIOSURF BIOTECH CO LTD
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