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Pulp capping agent for treating dental pulp lesions as well as preparation method and application thereof

A technology for pulp capping and teeth, which is applied in the field of pulp capping agent for treating dental pulp lesions and its preparation, can solve the problems of slow curing, degeneration and necrosis of dental pulp tissue, and local pH value increase, and achieves the promotion of formation and good biocompatibility. the effect of improving compatibility

Pending Publication Date: 2020-03-06
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, Ca(OH) 2 It will increase the local pH value, lead to the degeneration and necrosis of the covering pulp tissue, form a dentin bridge, and obtain restorative dentin, but the long-term clinical success rate is not high
MTA is a gray powder preparation mixed with various hydrophilic oxidized minerals. It is mainly composed of tricalcium aluminate, tricalcium silicate, tricalcium oxide, and silicate oxide. After meeting with water, MTA will form a colloidal gel with significantly increased pH, which has good biocompatibility and sealing, and can promote the regeneration of hard tissues, but its slow curing makes the affected teeth unable to bear the occlusal force within a few hours of treatment , and its poor compressive strength cannot be used for the repair of occlusal functional areas

Method used

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  • Pulp capping agent for treating dental pulp lesions as well as preparation method and application thereof
  • Pulp capping agent for treating dental pulp lesions as well as preparation method and application thereof
  • Pulp capping agent for treating dental pulp lesions as well as preparation method and application thereof

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preparation example Construction

[0051] The preparation method of the present invention will be further described in detail in conjunction with specific examples below. It should be understood that the following examples are only for illustrating and explaining the present invention, and should not be construed as limiting the protection scope of the present invention. All technologies realized based on the above contents of the present invention are covered within the scope of protection intended by the present invention.

[0052] The experimental methods used in the following examples are conventional methods unless otherwise specified; the reagents and materials used in the following examples can be obtained from commercial sources unless otherwise specified.

[0053] In the present invention, the term "optionally" means that the feature exists or does not exist. Taking "optionally adding a hydrophilic polymer material" as an example, it means "adding a hydrophilic polymer material The feature of "materia...

Embodiment 1

[0055] A kind of preparation of the dental pulp capping agent of the restorative material of a kind of bioactive particles-can initiate polymerization, the steps are as follows:

[0056] Mix Bis-GMA and TEGDMA at a weight ratio of 1:1, and add a small amount of photoinitiator (camphorquinone, CQ) to obtain a repair material that can initiate polymerization. The bioactive particles (composed of P 2 o 5 -11mol%, SiO 2 -55mol%, CaO-35mol% calcium phosphosilicate glass) and the restorative material capable of initiating polymerization are mixed in a weight ratio of 1:2 to obtain a tooth pulp capping agent. Light curing for 60s, put it in artificial saliva for 24h, it was found that it can promote the formation of hydroxyapatite mineralization layer (such as figure 1 shown), and its pH is stable, such as figure 2 shown.

Embodiment 2

[0058] A kind of preparation of the dental pulp capping agent of the restorative material of a kind of bioactive particles-can initiate polymerization, the steps are as follows:

[0059] Bis-GMA, TEGDMA and 1,3-butanediol disalicylate were mixed in a weight ratio of 1:1:0.1, and a small amount of photoinitiator (camphorquinone, CQ) was added to obtain a repair material that could initiate polymerization. Then bioactive particles (strontium phosphosilicate glass and tricalcium phosphate with a mass ratio of 1:1, wherein the composition of the strontium phosphosilicate glass is P 2 o 5 -11mol%, SiO 2 -55mol%, CaO-29mol%, SrO-5mol%) and the restorative material capable of initiating polymerization are mixed in a weight ratio of 2:3 to obtain a tooth pulp capping agent. Light-cured for 60s, co-cultured with cells, it was found that it can promote the proliferation of dental pulp cells, such as image 3 As shown in , the higher the absorbance value, the greater the detected prol...

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Abstract

The invention provides a pulp capping agent for treating dental pulp lesions as well as a preparation method and application thereof. Bioactive particles release PO4<3-> ions in an oral environment topromote rapid deposition of Ca<2+> and PO4<3-> on the surface of the material, so that a mineralization layer is formed rapidly; the released metal ions and PO4<3-> play a neutralization role and thus the material has the stable pH value in the body fluid, so that the compatibility with the dental pulp cells is improved and the dental pulp cells are promoted to differentiate into the teeth. The dental pulp capping agent can be used in different ways based on different components. The pulp capping agent that is prepared by compounding of bioactive particles such as phosphosilicate glass, phosphosilicate ceramic and a restorative material causing polymerization covers the surfaces of teeth after being subjected to photo-induced polymerization and solidification, so that rapid formation of dental pulp and tooth tissues is induced and thus dental pulp lesions are treated. Moreover, the pulp capping agent prepared by including solid-phase powder and the liquid phase coats the surface of dental pulp uniformly to treat the dental pulp lesions.

Description

technical field [0001] The invention belongs to the technical field of dental biomedical materials, and in particular relates to a pulp capping agent for treating dental pulp lesions, a preparation method and application thereof. Background technique [0002] Dental caries is a common and frequently-occurring disease clinically, and can be divided into shallow caries, medium caries and deep caries according to the degree of caries. Superficial and moderate caries can be treated with amalgam, glass ionomer cement and composite resin filling, and satisfactory clinical results have been achieved so far; for deep caries, the living pulp should be preserved to the greatest extent, mainly through pulp capping in clinical practice. Surgical preservation of vital pulp means covering the pulp wound with materials that can restore the effect of pulp lesions, so as to eliminate the lesions and protect the pulp. [0003] The commonly used pulp capping agent in clinic is Ca(OH) 2 and t...

Claims

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Application Information

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IPC IPC(8): A61K6/836A61K6/838A61K6/80A61K6/887A61K6/20A61K6/15
Inventor 邱东李爱玲
Owner INST OF CHEM CHINESE ACAD OF SCI
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