The invention relates to an artificial core containing controllable and movable fluid, and a manufacturing method of the artificial core. The manufacturing method mainly comprises the following steps: firstly, evenly stirring quartz sand, traditional epoxy resin cement and sub-nanoscale powder cement, wherein the median particle diameter of the sub-nanoscale powder cement is within the range from 0.7 to 1.0mu m, and the sub-nanoscale powder cement is formed by tricalcium silicate, dicalcium silicate, tricalcium aluminate and crystallized calcium sulfate according to the mass ratio of (0.20-0.25) to (0.30-0.35) to (0.25-0.35) to (0.20-0.30); putting the mixture into a cylindrical steel mould, pressurizing, and drying at high temperature to obtain the artificial core. Due to the change of proportions of two types of mixtures, the artificial core has better similarity with the natural core in the macroscopic aspects such as porosity and permeability, and the distribution proportion of the movable fluid is changed within the specific range on the basis that different levels of pores in the artificial core reach the specific proportion; furthermore, the artificial core is higher in accuracy, thus meeting the experimental demands such as oil field three-mining chemical flooding optimization, and microscopic use law.