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Glucosamine chondroitin sulfate salt and preparation method and application thereof

A technology of glucosamine and chondroitin sulfate, which is applied in the direction of medical formulas, bone diseases, medical preparations containing active ingredients, etc., can solve problems such as electrolyte disorders, and achieve the effects of reducing the level of inflammatory factors, good therapeutic effect, and high purity

Active Publication Date: 2020-03-10
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the single product of glucosamine inorganic salt, single product of chondroitin sulfate, and their composite products all have metal ions and inorganic anions, so there is a risk and potential danger of causing electrolyte disturbance in the body. It is urgent to remove small molecule inorganic salts and reduce its side effects

Method used

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  • Glucosamine chondroitin sulfate salt and preparation method and application thereof
  • Glucosamine chondroitin sulfate salt and preparation method and application thereof
  • Glucosamine chondroitin sulfate salt and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh 5 g of chondroitin sulfate with a molecular weight of 2000 and 5 g of glucosamine hydrochloride, dissolve them in water, dialyze in a dialysis bag with a molecular weight cut-off of 100 for 1 day, concentrate by rotary evaporation, and freeze-dry to obtain glucosamine sulfate chondroitin salt.

Embodiment 2

[0037] The difference from Example 1 is:

[0038] Weigh 2.5g of chondroitin sulfate with a molecular weight of 5000 and 5g of glucosamine hydrochloride, dissolve them in water, dialyze in a dialysis bag with a molecular weight cut-off of 200 for 3 days, concentrate by rotary evaporation, precipitate with ethanol, suction filter, and dry at 60 degrees Celsius Dry for 8 hours to obtain glucosamine chondroitin sulfate salt.

Embodiment 3

[0040] The difference from Example 1 is:

[0041] Weigh 1g of chondroitin sulfate with a molecular weight of 10,000 and 5g of glucosamine hydrochloride, dissolve them in water, use ion exchange, remove metal ions through a cation exchanger, and then enter an anion exchanger to remove anions to obtain glucosamine sulfate chondroitin saline solution, spray-dried to obtain glucosamine sulfate chondroitin salt.

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Abstract

The invention relates to the industries of functional food and medicine, in particular to a glucosamine chondroitin sulfate salt as well as a preparation method and application thereof. The structuralformula of the glucosamine chondroitin sulfate salt is shown as a formula (1), and the value range of the average polymerization degree n is 5-1000. The glucosamine chondroitin sulfate salt is obtained by performing ion exchange on glucosamine hydrochloride or sulfate or phosphate and chondroitin sulfate sodium, or dialyzing with a mixed solution, or directly precipitating with the mixed solution, , the molecular weights of chondroitin sulfates are all polysaccharides which are obtained through natural extraction, fermentation preparation or degradation, or a synthesis method and accord withthe chondroitin sulfate structures. The chondroitin sulfate and glucosamine are organically combined together, the glucosamine chondroitin sulfate salt is different from an existing compound product of the chondroitin sulfate and the glucosamine, the glucosamine chondroitin sulfate salt does not contain micromolecular inorganic salts or is very low in content of the micromolecular inorganic salts,and the prepared glucosamine chondroitin sulfate salt has a good treatment effect on osteoarthritis model rats in an oral gavage mode; the micromolecular inorganic salts be used for but not limited to joint treatment or auxiliary health care. The glucosamine chondroitin sulfate salt can be widely applied to the fields of functional foods and medicines.

Description

technical field [0001] The invention relates to functional food and pharmaceutical industries, in particular to a glucosamine sulfate chondroitin salt, a preparation method and application thereof. Background technique [0002] Chondroitin sulfate is a kind of glycosaminoglycan, which is widely distributed in the extracellular matrix and cell surface of animal tissues. The sugar chain consists of alternating glucuronic acid and N-acetylgalactosamine (also known as N-acetylgalactosamine) two Consisting of sugar units, chondroitin sulfate is found in all organisms from nematodes to humans except plants, where it performs many important physiological functions. The main application of chondroitin sulfate in medicine is as a drug for the treatment of joint diseases, which can improve joint problems. At the same time, chondroitin sulfate can effectively prevent and treat coronary heart disease, and has anti-atherosclerosis and anti-atherogenic plaque formation effects on experim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A61K31/737A61P19/02
CPCC08B37/0069A61K31/737A61P19/02
Inventor 郭占勇谭文强王刚董方李青
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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