Preparation method of highly stable hydrophilic coating for surface of medical device

A hydrophilic coating and medical device technology, applied in the field of medical devices, can solve the problems of uncontrollable drug release, low drug loading, poor stability, etc., and achieve excellent super-hydrophilic performance, good biocompatibility and resistance Effects on blood coagulation function and highly stable performance

Active Publication Date: 2020-03-17
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are mainly three methods for preparing such functional coatings: the first is to carry out graft modification on the surface of medical devices. Complicated and costly; the second is to directly coat functional coatings on the surface of medical devices, commonly used are nanomaterial coatings, PEG coatings, zwitterionic polymer coatings, etc. The preparation method of this coating is simple, However, the stability is poor; the third method is drug-loaded coating. This method not only has a small drug load, but also has problems such as unstable coating and uncontrollable drug release.

Method used

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  • Preparation method of highly stable hydrophilic coating for surface of medical device
  • Preparation method of highly stable hydrophilic coating for surface of medical device
  • Preparation method of highly stable hydrophilic coating for surface of medical device

Examples

Experimental program
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Embodiment 1

[0037] A method for preparing a hydrophilic coating on the surface of a medical device, comprising the following steps:

[0038] (1) Set the size to 1×1cm 2 Polishing, cleaning and drying of medical device substrates;

[0039] (2) Preparation of the adhesive layer: Dissolve dopamine hydrochloride and polyethyleneimine in a concentration of 0.05M Tris-HCl buffer solution (pH=8.5) at a mass ratio of 1:1, and dissolve the base in step (1) Place the material in the above mixed solution and vibrate at 180 rpm for 8 hours at a constant temperature of 25°C, then take out the base material and ultrasonically clean it for 30 minutes, then put it in a vacuum drying oven at 40°C for 2 hours in vacuum;

[0040] (3) Preparation of hydrophilic coating: Polydopamine carboxybetaine (Mw=10000, 5mg / mL) was dissolved in 0.05M Tris-HCl buffer (pH=8.5), and then step (2) was processed The base material was placed in the above solution, and was shaken at a speed of 150 rpm for 24 h at a constant ...

Embodiment 2

[0056] (1) Set the size to 1×1cm 2 Polishing, cleaning and drying of medical device substrates;

[0057] (2) Preparation of the adhesive layer: dissolving gallic acid and polyethyleneimine in a concentration of 0.05M Tris-HCl buffer solution (pH=8.5) at a mass ratio of 2:1, the base in step (1) The materials were placed in the above mixed solution and shaken at 170 rpm for 8 hours at a constant temperature of 28°C. Then take out the substrate and ultrasonically clean it for 30 minutes, then put it into a vacuum drying oven at 40°C for 2 hours in vacuum;

[0058] (3) Preparation of hydrophilic coating: Polydopamine phosphorylcholine (Mw=15000, 2mg / mL) was dissolved in Tris-HCl buffer (pH=8.5) with a concentration of 0.05M, and the The sheet was placed in the above solution and reacted at 170 rpm for 24 hours at a constant temperature of 25°C, then the substrate was taken out and ultrasonically cleaned for 30 minutes, and then placed in a vacuum oven at 40°C for 2 hours of vac...

Embodiment 3

[0060] (1) Set the size to 1×1cm 2 Polishing, cleaning and drying of medical device substrates;

[0061] (2) Preparation of the adhesive layer: it is the Tris-HCl buffer solution (pH=8.5) of 0.05M that dopamine hydrochloride and chitosan are dissolved in the condition of 2:1 with the mass ratio, and the Place the substrate in the above mixed solution and vibrate at 180 rpm for 7 hours at a constant temperature of 28°C, then take out the substrate and ultrasonically clean it for 30 minutes, then put it in a vacuum drying oven at 40°C for 2 hours in vacuum;

[0062] (3) Preparation of hydrophilic coating: Polydopamine sulfonate betaine (Mw=20000, 3mg / mL) was dissolved in Tris-HCl buffer (pH=8.5) with a concentration of 0.05M, and the The base material was placed in the above solution at a constant temperature of 30°C and vibrated at 150rpm for 24h, then the sheet was taken out and ultrasonically cleaned for 30min and then placed in a vacuum oven at 40°C for 2h in vacuum.

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Abstract

The invention provides a preparation method of a highly stable hydrophilic coating for the surface of a medical device. The method comprises (1) a step of polishing, washing and drying the surface ofa medical instrument substrate; (2) a step of preparing an adhesive layer, namely a step of dissolving a compound containing a catechol component and a polyamino compound into a Tris-HCl buffer solution having a concentration of 0.05M and pH of 8.5 in a mass ratio of 1-2:1, and preparing the adhesive layer on the substrate; (3) a step of hydrophilic coating preparation, namely a step of dissolvinga zwitterionic polymer containing a dopamine group component into a Tris-HCl buffer solution having a concentration of 0.05M and pH of 8.5, and preparing a hydrophilic coating on the substrate. The method is simple to operate, mild in conditions and universal. The prepared hydrophilic coating has super hydrophilicity, good biocompatibility, anticoagulant properties, and high stability, and has good application prospect in the field of medical devices.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a highly stable preparation method for a hydrophilic coating on the surface of medical devices. Background technique [0002] Medical devices and biological implants can cause infections in patients, and the current situation is becoming more and more serious, which has posed a serious threat to public health. However, the coating of functional coatings on the surface of medical devices makes medical devices hydrophilic and lubricating. , Antibacterial, anticoagulant, anti-proliferation and other properties have become important technical means to improve the efficacy of medical devices, reduce patient discomfort, enhance treatment effects, and reduce infection rates. [0003] Hydrophilic coatings are coatings that exhibit strong chemical interactions with water (eg, by forming hydrogen bonds with surrounding water molecules), and coating materials and prepara...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J179/02C09J105/08C09J11/06C09D179/04A61L31/10A61L31/14
CPCA61L31/10A61L31/14A61L2400/18A61L2420/02C09D179/04C09J11/06C09J105/08C09J179/02C08K5/18C08K5/13C08L5/08C08L79/02
Inventor 刘公岩夏琼芬刘玉琪
Owner SICHUAN UNIV
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