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A kind of metronidazole tablet and preparation method thereof

A technology for metronidazole tablets and metronidazole is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., and can solve the problems of unsatisfactory dissolution effect, poor drug efficacy and the like, Achieve the effect of improving dissolution effect, improving quality and curative effect, and stabilizing the preparation process

Active Publication Date: 2022-04-05
北京鑫开元医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to overcome the above-mentioned deficiencies of the prior art, to provide a metronidazole tablet and a preparation method thereof, aiming to solve the technical problem that the dissolution effect of the existing metronidazole tablet is not ideal, resulting in poor drug efficacy

Method used

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  • A kind of metronidazole tablet and preparation method thereof
  • A kind of metronidazole tablet and preparation method thereof
  • A kind of metronidazole tablet and preparation method thereof

Examples

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preparation example Construction

[0060]The second aspect of the embodiments of the present invention provides a method for preparing metronidazole tablets, comprising the following steps: Step S10: pulverize the metronidazole raw material and pass through a first mesh sieve to obtain metronidazole, the metronidazole The particle size of nidazole is not greater than 300 microns.

[0061] The mesh number of the first mesh sieve can be set as required, for example, it can be 60 mesh sieves. After pulverizing the metronidazole raw material, the particle size of the metronidazole raw material can be screened through the first mesh sieve, so that the particle size of the obtained metronidazole is not greater than 300 microns. On the one hand, when the particle size of the raw material powder is too fine, the material will aggregate and affect the disintegration of the product, thereby affecting the dissolution; on the other hand, when the particle size of the raw material powder is too large, the effect of forming ...

Embodiment 1

[0089] Metronidazole is not pulverized and sieved, the D90 is about 300 microns, and the D90 of calcium hydrogen phosphate is about 200 microns.

[0090] Taking the total mass of the metronidazole tablet as 100%, the composition of the mass percentage that the metronidazole tablet includes is:

[0091]

[0092] Metronidazole tablet preparation method is as follows:

[0093] Step S601: Take the metronidazole raw material for later use.

[0094] Step S602: Weigh the metronidazole, filler and disintegrant according to the preset mass percentage, mix them uniformly in a wet granulator, add the binder for less than 5 minutes to granulate, and pass through a 20-mesh sieve to obtain wet granules , wherein the particle size of the filler is 200 microns.

[0095] Step S603: drying the wet granules, the drying temperature is not higher than 60° C., and the moisture content of the dried granules is 2.5%.

[0096] Step S604: After the wet granules are dried, the granules are sized, ...

Embodiment 2

[0101] Metronidazole is not pulverized and sieved, the D90 is about 250 microns, and the D90 of calcium hydrogen phosphate is about 120 microns.

[0102] Taking the total mass of the metronidazole tablet as 100%, the composition of the mass percentage that the metronidazole tablet includes is:

[0103]

[0104] Metronidazole tablet preparation method is as follows:

[0105] Step S701: Pulverize the metronidazole raw material, pass through a 60-mesh sieve, and set aside.

[0106] Step S702: Weigh the metronidazole, filler and disintegrant according to the preset mass percentage, mix them uniformly in a wet granulator, add the binder for less than 5 minutes to granulate, and pass through a 20-mesh sieve to obtain wet granules , wherein the particle size of the filler is 200 microns.

[0107] Step S703: drying the wet granules, the drying temperature is not higher than 60° C., and the moisture content of the dried granules is 2.6%.

[0108] Step S704: After the wet granules...

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Abstract

The invention belongs to the technical field of medicines, and specifically relates to a metronidazole tablet and a preparation method thereof. The preparation method comprises: pulverizing the metronidazole raw material and passing through a first mesh sieve to obtain metronidazole. The metronidazole The particle size is not more than 300 microns; Metronidazole, filler and disintegrating agent are weighed according to the preset mass percentage and mixed uniformly in a wet granulator, added with a binder to granulate, and passed through a second mesh sieve to obtain a wet Granules, wherein the particle size of the filler is not greater than 150 microns; the wet granules are dried and sized, and the lubricant is added and mixed in a mixer to obtain intermediate granules; the intermediate granules are tableting, coating and packaging to obtain metronidazole tablets. The preparation method of the metronidazole tablet provided by the embodiment of the present invention has a stable process, ensures the product quality of the finally obtained metronidazole tablet, has a better dissolution rate, effectively improves its dissolution effect, and improves the quality and curative effect of the metronidazole tablet .

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a metronidazole tablet and a preparation method thereof. Background technique [0002] Metronidazole is a synthetic oral antiprotozoal and antibacterial drug, which may exert antibacterial activity in an anaerobic environment through the following mechanism: After the drug enters the body, it is affected by the intracellular ion transporter, forming a mechanism that promotes the transport of the drug into the cell. concentration gradient. The drug forms free radicals inside the cell, which in turn interact with intracellular components, ultimately leading to the death of the microorganism. Metronidazole has a wide range of uses and has obvious curative effects on a variety of bacterial diseases: [0003] (1) Treatment Treatment of intestinal and parenteral amoebiasis, such as peptic ulcer. Metronidazole is effective in treating peptic ulcer, can improve gastric m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K31/4164A61K47/36A61P33/02A61P31/04A61P1/04A61P11/00A61P3/06A61P1/02A61P7/04A61P15/00A61P15/02A61P17/00
CPCA61K9/28A61K9/2059A61K31/4164A61P33/02A61P31/04A61P1/04A61P11/00A61P3/06A61P1/02A61P7/04A61P15/00A61P15/02A61P17/00
Inventor 霍志强赵婷陈华王传旭霍燕武雪戴信敏
Owner 北京鑫开元医药科技有限公司