Diphenyl-pyrrolo-pyrrolidinedione conjugated oligomer, nanoparticles based on diphenyl-pyrrolo-pyrrolidinedione conjugated oligomer, and preparation methods thereof
A technology of diketopyrrolopyrrole and nanoparticle, applied in the field of materials, can solve problems such as less research, and achieve the effect of strong photothermal effect, broad application prospect and strong photothermal effect
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Embodiment 1
[0072] Embodiment 1, oligomer ODPP
[0073] according to figure 1 The synthetic route shown for the preparation of thienylpyrrolopyrrole diketopyrrole oligomers (ODPP)
[0074] 1) Synthesis of 3,6-bis(thiophen-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione
[0075] Add sodium tert-amyloxide (24.8g, 225mmol) into 90mL of tert-amyl alcohol under argon atmosphere, raise the temperature to 90°C and stir for 0.5h to dissolve it completely, and drop 2-cyanothiophene (16.4g, 150mmol) After adding to the solution, diisopropyl succinate (12.1 g, 60 mmol) was slowly added dropwise, and the color of the suspension turned dark red. After the addition, the stirring reaction was continued at this temperature for 2h. Lower the reaction temperature to 50°C, then add 65 mL of methanol to dilute, and neutralize with 25 mL of glacial acetic acid, stir at this temperature for 15 min, and cool to room temperature. The reaction mixture was filtered, and the filter cake was extracted with anhydrous...
Embodiment 2
[0099] Embodiment 2, the preparation of oligomeric nanoparticle
[0100] This example only provides a method for preparing nanoparticles by using the nanoprecipitation method, and the amphiphile molecules are not limited to those used in this example.
[0101] 1) Weigh the ODPP (0.5mg) prepared in Example 1, dissolve DSPE-PEG-MAL (6mg) in 1mL THF, and sonicate the mixture for 30min;
[0102] 2) Add triethylamine (7.28mg / mL, 34uL) and polyethyleneimine (PEI) (15.875mg / mL, 16uL) to the mixture according to 50% of the oligomer mass, and stir overnight;
[0103] 3) Add the above mixture into 9mL ultrapure water, after ultrasonication for 10min, stir for 5h, and blow inert gas into the solution until all THF volatilizes;
[0104] 4) Dialyze the aqueous solution of nanoparticles (molecular weight cut off is 3500) to remove excess PEI molecules, filter the retentate with a 220nm filter membrane, and store the obtained aqueous solution of nanoparticles at -4°C.
[0105] image 3 Th...
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