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Electrochemical sensor for detecting epinephrine and preparation method and application thereof

An adrenaline and electrochemical technology, applied in chemical instruments and methods, material electrochemical variables, inorganic chemistry, etc., can solve problems such as difficult simultaneous sensitive analysis and stable detection, weak electrochemical response, etc., to achieve good stability and weight Reproducibility, strong electrochemical behavior, and the effect of improving sensitivity

Active Publication Date: 2020-03-27
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high oxidation potential and weak electrochemical response of adrenaline, it is difficult for existing electrochemical sensors to achieve sensitive analysis and stable detection of it at the same time.

Method used

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  • Electrochemical sensor for detecting epinephrine and preparation method and application thereof
  • Electrochemical sensor for detecting epinephrine and preparation method and application thereof
  • Electrochemical sensor for detecting epinephrine and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: An electrochemical sensor for detecting adrenaline, based on nickel@manganese oxide (Ni 6 MnO 8 ) nanomaterials, the preparation method of the electrochemical sensor is:

[0019] (1) Preparation of nickel@manganese oxide (Ni 6 MnO 8 ): 0.05 mol / L Ni (NO 3 ) 2 ·6H 2 O and 0.025mol / L Mn (NO 3 ) 2 4H 2 O was dissolved in 40 mL of solvent (1:3 ratio of ethylene glycol and ultrapure water). Add 10 mL of 0.1mol / L urea to the above mixture and keep stirring for 30 min until completely dissolved. Thereafter, the resulting mixture was sealed in a Teflon-lined autoclave and heated at 180 °C for 12 h; the autoclave was subsequently cooled to room temperature, and the cooled dispersion solution was centrifuged at 9000 rpm for 30 min to collect the solid and wash with ethanol and ultrapure Water was washed successively until neutral; the resulting solid was dried overnight at 60°C. The pre-prepared samples were annealed at 400 °C in air for 3 h, and the product...

Embodiment 2

[0021] Example 2: An electrochemical sensor for detecting adrenaline, based on nickel@manganese oxide (Ni 6 MnO 8 ), the preparation method of the electrochemical sensor is as follows: in step (1), the autoclave is heated at 190° C. for 14 h. Nickel@manganese oxide Ni in step (2) 6 MnO 8 The concentration is 0.5 mg / mL; the ultrasonic time is 20 min. In step (2), 8.0 μL of the dispersed liquid was applied onto the surface of the glassy carbon electrode; it was dried under an infrared lamp for 5 min. All the other preparation methods are the same as those described in Example 1.

Embodiment 3

[0022] Example 3: An electrochemical sensor for detecting adrenaline, based on nickel@manganese oxide (Ni 6 MnO 8 ), the preparation method of the electrochemical sensor is as follows: in step (1), the autoclave is heated at 200°C for 146h. Nickel@manganese oxide Ni in step (2) 6 MnO 8 The concentration was 1.5 mg / mL; the ultrasonic time was 10 min. In step (2), 6.0 μL of the dispersed liquid was applied onto the surface of the glassy carbon electrode; it was dried under an infrared lamp for 15 min. All the other preparation methods are the same as those described in Example 1.

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PUM

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Abstract

The invention belongs to the technical field of electrochemical electrode material preparation, and provides an electrochemical sensor for detecting epinephrine and a preparation method and application thereof. The electrochemical sensor is a nano material of nickel-manganese oxide Ni6MnO8 prepared by a hydrothermal method and calcination, and the electrochemical sensor is prepared by modifying the surface of a glassy carbon electrode with the obtained nano material of nickel-manganese oxide Ni6MnO8. The electrochemical sensor has high sensitivity and selectivity, the electrode modification process is simpler and more convenient, and good stability and reproducibility are achieved. The electrode modification process is simpler and more convenient, and the electrochemical sensor has high sensitivity and selectivity and good stability and reproducibility. The nickel and manganese oxide (Ni6MnO8) is prepared through a hydrothermal method and calcination, and then the electrode is prepared. The sensitivity of the electrode is improved; and the electrode modification process is simpler. The electrochemical sensor is used for constructing a sensing system for detecting epinephrine in saliva, and the selectivity of the electrode is remarkably improved.

Description

technical field [0001] The invention belongs to the technical field of preparation of electrochemical electrode materials, and in particular relates to an electrochemical sensor for detecting epinephrine and its preparation method and application. The electrochemical sensor is based on nickel@manganese oxide (Ni 6 MnO 8 ) electrochemical sensor for the detection of epinephrine in saliva. Background technique [0002] Epinephrine (EP) is one of the most important and best-known catecholamine neurotransmitters in the mammalian central nervous system, which plays an important role in the transmission of nerve impulses. Epinephrine is used to treat cardiac arrest, heart block, asthma, nasal congestion, high blood pressure, etc. It increases heart rate, constricts blood vessels, and dilates air passages. These important effects also make it an effective stimulant. As a result, the World Anti-Doping Agency has banned its use in track and field competitions. Moreover, monitorin...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N27/30G01N27/48C01G53/00B82Y15/00B82Y30/00
CPCG01N27/3278G01N27/3277G01N27/308G01N27/48C01G53/00B82Y30/00B82Y15/00
Inventor 雷鹏朱瑞琦周影双少敏
Owner SHANXI UNIV
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