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Application of p-hydroxyphenylpropionic acid in preparation of medicine for preventing and treating respiratory tract infection

A kind of technology of para-hydroxyphenylpropionic acid and respiratory tract, which is applied in the application field of para-hydroxyphenylpropionic acid in preparing medicine for preventing and treating respiratory tract infection

Inactive Publication Date: 2020-03-31
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature disclosing the relevant role of p-hydroxyphenylpropionic acid in the prevention and treatment of respiratory tract infections

Method used

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  • Application of p-hydroxyphenylpropionic acid in preparation of medicine for preventing and treating respiratory tract infection
  • Application of p-hydroxyphenylpropionic acid in preparation of medicine for preventing and treating respiratory tract infection
  • Application of p-hydroxyphenylpropionic acid in preparation of medicine for preventing and treating respiratory tract infection

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0008] Example 1: Evaluation of the pharmacodynamic effect of HPPA on lung injury

[0009] Experimental materials: lipopolysaccharide O55:B5, sodium pentobarbital, Memmert UFE400 oven, Mettler Toledo MS205DU 1 / 100,000 electronic balance.

[0010] Experimental animals: 42 SPF male Balb / c mice, 8-9 weeks old, weighing 18-20g, purchased from Jinan Pengyue Experimental Animal Breeding Co., Ltd. (animal license number SCXK (Lu) 20190003, use license number SYXK (Guangdong) 2016-0112).

[0011] Experimental method: The mice were acclimatized in a constant temperature and humidity SPF grade animal room for 72 hours after purchase. The mice were randomly divided into 4 groups, respectively blank control group (n=10), model control group (n=10), positive control drug naringin group (n=11), p-hydroxyphenylpropionic acid group (n= 11). Among them, the naringin group (180 mg / kg) and the p-hydroxyphenylpropionic acid group (51.6 mg / kg) were administered intragastrically for three consec...

Embodiment 2

[0021] Example 2: Improvement of Chronic Lung Injury Caused by Smoke

[0022] Experimental animals: SPF grade Balb / c mice, male, weighing 19-23 g, were purchased from Guangdong Medical Experimental Animal Center (Guangzhou, China). Feeding conditions: day and night alternation for 12 hours, temperature 21°C, humidity 60%, free feeding.

[0023] Experimental equipment: smoke box (self-made stainless steel box 0.8m×0.8m×1m); 1 / 100,000 analytical balance (Germany Acculab company, model: ALC-210-4); 5430R high-speed centrifuge (Germany Eppendorf company) ; Porous ultra-trace nucleic acid protein analyzer (Biotek, USA, model: Epoch); ultra-low temperature refrigerator (Haier, China, model: DW-86L486); vortex mixer (SI company, USA, model: SI-0246); XT -2000IV automatic animal hematology analyzer (Japan Sysmex Company), etc.

[0024] Experimental grouping: Animals were randomly divided into blank group, smoked model group, HPPA low-dose and high-dose groups (15, 60 mg / kg) and rofl...

Embodiment 3

[0045] Embodiment 3: Research on antibacterial activity in vitro

[0046] Experimental equipment: 1 / 100,000 electronic analytical balance (BP211D, Satorius, Germany), high-pressure high-temperature sterilizer (GR 60DA), ultrasonic vibration cleaner (KQ-250DE, Kunshan Ultrasonic Instrument Co., Ltd.), pipette gun (France Gilson), McFarland turbidimeter (VITEK 2DensiCHEK Plus, 27208densitometer densichek kit220), McFarland turbidimetric tube (France Mérieux company), bacterial constant temperature incubator (HPX-9162MBE electric heating constant temperature incubator, Changzhou Nuoji Instrument Co., Ltd.), Sterile 96-well plate (JET BIOFIL), 90mm Columbia blood agar medium (43041 COLUMBIA 5% SHEEP BL, French company Mérieux).

[0047] Experimental strains: 10 strains of Staphylococcus aureus (number S1-S10) and 12 strains of Klebsiella pneumoniae (number K1-K12) used in the experiment were provided by the Laboratory Department of the First Affiliated Hospital of Sun Yat-sen Univ...

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Abstract

The invention relates to a novel pharmaceutical application of p-hydroxyphenylpropionic acid. The tests prove that the p-hydroxyphenylpropionic acid has a remarkable pharmacological effect in inhibiting respiratory tract infection, particularly pulmonary edema, inflammatory cell infiltration and cell apoptosis in lung injury and delaying lung function degradation of mice. Therefore, the inventiondiscloses the application of p-hydroxyphenylpropionic acid in preparing a medicine for preventing and treating respiratory tract infection, particularly pneumonia, pulmonary edema or pulmonary epithelial and / or endothelial cell necrosis in lung injury for the first time.

Description

technical field [0001] The invention relates to the new medicinal application of p-hydroxyphenylpropionic acid, especially the application in the preparation of medicines for preventing and treating respiratory tract infection. Background technique [0002] Respiratory tract infection is a common disease, divided into upper respiratory tract infection and lower respiratory tract infection. Severe conditions can lead to lung injury, especially acute lung injury, which is a type of acute respiratory distress syndrome and a common clinical emergency. The pathological changes of acute lung injury mainly include extensive inflammatory response in the lungs, recruitment of neutrophils, pulmonary interstitial edema, damage to the integrity of epithelial cells, increased microvascular permeability, and gas exchange disorders. According to statistics, the fatality rate of acute lung injury can account for 34.9% of the total number of hospital deaths. Currently, there are no drugs a...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P31/04A61P11/00
CPCA61K31/192A61P31/04A61P11/00
Inventor 吴灏陈韬彬王永刚苏薇薇
Owner SUN YAT SEN UNIV