Long afterglow nano-composite and application thereof in multi-modal imaging and synergistic treatment of tumors
A nano-composite, long afterglow technology, applied in the field of biomedicine, can solve the problems of limited stability of photosensitizers, difficult to achieve expected therapeutic effect, and inability to synergize treatment, and achieve improved sensitivity, reduced dosage, and reduced toxic and side effects. Effect
Active Publication Date: 2020-03-31
NORTHWESTERN POLYTECHNICAL UNIV
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Problems solved by technology
Photodynamic therapy is the use of photosensitizers to generate singlet oxygen to kill tumor cells under the irradiation of oxygen and excitation light. However, due to the low oxygen content in tumor tissues, the stability of photosensitizers is limited, so the actual therapeutic effect is difficult to achieve expectations.
At present, it is not possible to better realize photothermal, photodynamic and chemical dynamic synergistic therapy to enhance the therapeutic effect of tumors.
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[0039] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.
[0040]Near-infrared luminescent long-lasting nanomaterials, referred to as PLNP, have the outstanding advantage of being free from in-situ excitation, and can effectively avoid the self-luminescence or background interference of biological tissues themselves. In terms of actual imaging applications, when the afterglow is weak, white or red LED lights can be used for repeated excitation, so that the imaging time is no longer limited to the afterglow time of the material, which further expands the application range of long-afterglow nanomaterials. The ion composition, particle size distribution and surface modification of the material endow long-lasting nanomaterials with various functions, which can be used in many fields such as biological detection, medical imaging, and disease treatment.
[0041] In this embodiment, human serum albumin is r...
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Abstract
The invention discloses a long-afterglow nano-composite, which is prepared by loading a near-infrared absorption dye and Fe <3+> on human serum albumin and coating the surface of a long-afterglow nano-material with the human serum albumin, the long-afterglow nano-composite is in a core-shell structure, the long-afterglow nano-material is a core, and the human serum albumin loaded with the near-infrared absorption dye and the Fe <3+> is a shell. After use, multi-modal imaging can be realized, and more comprehensive biological tissue characteristics can be obtained, so that the biological tissuestructure, functional characteristics and early lesions can be imaged; and integration of multi-modal imaging and multi-means collaborative treatment can be realized.
Description
【Technical field】 [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a long afterglow nanocomposite and its application in tumor multimodal imaging and synergistic treatment. 【Background technique】 [0002] Cancer has become one of the major diseases that threaten human health and life. At present, MRI, X-ray tomography (CT), positron emission tomography (PET) and other imaging examination methods combined with histopathological analysis and tumor marker detection are used for diagnosis. These detection methods often have high cost, long cycle and low sensitivity, which cannot meet the clinical needs. The clinical treatment of tumors mainly includes surgical resection, radiotherapy, chemotherapy, etc. These treatments are difficult to eradicate tumor cells, have poor targeting and cause great damage to the body, and the patients are very painful. Therefore, the development of more effective diagnosis and treatment methods is an...
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IPC IPC(8): A61K49/22A61K49/18A61K49/14A61K49/00A61K41/00A61P35/00
CPCA61K41/0052A61K41/0057A61K49/0002A61K49/0021A61K49/0093A61K49/143A61K49/1869A61K49/225A61P35/00
Inventor 吴淑琪乔子涵李阳张连兵
Owner NORTHWESTERN POLYTECHNICAL UNIV