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A cardiovascular stent for rapidly promoting vascular endothelialization and preparation method thereof

A cardiovascular and vascular technology, applied in the field of rapidly promoting vascular endothelialization of a cardiovascular stent and its preparation, can solve the problems of breaking the vascular homeostasis, increasing vasoconstrictor factors, reducing vasodilator factors, etc., and achieves the effect of promoting anticoagulation, The effect of promoting vascular endothelialization and uniform particle size

Active Publication Date: 2021-05-14
BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the vascular endothelium is affected by a series of harmful factors, the release of vasodilation factors from endothelial cells decreases and the vasoconstriction factors increase, which breaks the homeostasis of blood vessels and eventually leads to a series of cardiovascular events.

Method used

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  • A cardiovascular stent for rapidly promoting vascular endothelialization and preparation method thereof
  • A cardiovascular stent for rapidly promoting vascular endothelialization and preparation method thereof
  • A cardiovascular stent for rapidly promoting vascular endothelialization and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0043] The preparation method of the above-mentioned copper-zinc-magnesium-doped silicon-based mineral powder includes:

[0044] (1) First, add methanol and deionized water into the reactor, then add catalyst concentrated hydrochloric acid and stir evenly, and measure the pH between 0.8-1.3.

[0045] (2) Then, trialkoxysilane was added dropwise, and after the dropwise addition was completed, the reaction was stirred at 30-50° C. for 6-8 hours to carry out the hydrolysis reaction.

[0046] (3) Then, add copper-containing salts, zinc-containing salts, and magnesium-containing salts, and stir and react at 60-80 ° C for 4-8 h to promote the polycondensation of the hydrolyzate to form polyhedral cage-type polysilsesquioxane, and make it with Mix the salt evenly.

[0047] (4) The reaction product was distilled under reduced pressure to remove methanol, and the obtained product was placed to age for 48h.

[0048] (5) Spread the aged product in an oven at 100-120 degrees and bake fo...

Embodiment 1

[0074] The preparation method of the cardiovascular stent for rapidly promoting vascular endothelialization of the present embodiment includes the following steps:

[0075] (1) Powder preparation: The bioactive mineral material, Regesi regenerated silicon V-type produced by Beijing Happiness Probiotics, was screened, and then dried at 120 °C to form powder particles with a particle size of 300 nm.

[0076] (2) stent preparation: the medical stainless steel stent substrate is polished with different surface roughness, the surface roughness reaches 0.1, and then sterilized with a γ-ray Co60 irradiation dose of 20-35kGy for use.

[0077] (3) Supersonic cold spraying: using supersonic cold spraying, the above-mentioned powder particles enter the supersonic accelerated airflow at an off-axis of 45°, and the powder feeding flow rate is 0.5g / min to form a gas-solid two-phase flow. Impacted and deposited on the surface of the cardiovascular stent to form a coating, the bioactive miner...

Embodiment 2

[0083] The preparation method of the cardiovascular stent for rapidly promoting vascular endothelialization of the present embodiment includes the following steps:

[0084] (1) Powder preparation: The bioactive mineral material adopts the Regesi active silicon V type produced by Beijing Happiness Probiotics, and the operation method is the same as that of Example 1 to form powder particles with a particle size of 300 nm.

[0085] (2) Scaffold preparation: The scaffold substrate and the operation method in this step are the same as in Example 1, and the surface roughness of the scaffold substrate is 0.1.

[0086] (3) Supersonic cold spraying: using supersonic cold spraying, the above-mentioned powder particles enter the supersonic accelerated airflow at an off-axis of 40°, and the powder feeding flow rate is 1g / min to form a gas-solid two-phase flow, which is impacted at 150 °C , and deposited on the surface of the cardiovascular stent to form a coating, the bioactive mineral m...

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Abstract

The invention belongs to the technical field of bioengineering of medical materials, in particular to a cardiovascular stent for rapidly promoting vascular endothelialization and a preparation method thereof. The blood vessel stent includes a stent body and a coating arranged on the surface of the stent body, and the material of the coating is bioactive mineral material. In the preparation method, the bioactive mineral material is covered on the surface of the stent base material by supersonic cold spraying to form a coating, so as to obtain the cardiovascular stent for rapidly promoting vascular endothelialization. The present invention adopts bioactive mineral material as the coating raw material on the cardiovascular stent, so that the cardiovascular stent has excellent biocompatibility; the surface of the cardiovascular stent has a layered multi-diameter bioactive mineral material with uniform particle size, Anti-corrosion and strong scouring ability; supersonic cold spraying is adopted, so that the powder particles formed by biologically active minerals are not melted, and only physical deformation occurs on the surface of the stent, thus ensuring the quality of the coating.

Description

technical field [0001] The invention belongs to the technical field of medical material bioengineering, in particular to a cardiovascular stent for rapidly promoting vascular endothelialization and a preparation method thereof. Background technique [0002] Cardiovascular embolism has become the most common disease in people's health around the world. Experts and scholars from various countries are actively looking for an ideal cardiovascular stent, which can provide certain mechanical properties after implantation in the blood vessel, and expand and stabilize the blood vessel. After that, the scaffold material can be gradually degraded in vivo with the recovery of bodily functions. With the wide application of vascular stents implanted in the human body, aging, shedding, rejection and other reactions will occur after the stent is implanted in the body, which will stimulate the surrounding tissues of blood vessels to a certain extent, resulting in different degrees of vascul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/82A61L31/08A61L31/14A61L31/16
CPCA61F2/0077A61F2/82A61F2002/0086A61F2210/0004A61F2240/002A61L31/086A61L31/088A61L31/14A61L31/146A61L31/16A61L2420/02
Inventor 胡方王健仇越秀
Owner BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD