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Antibacterial alginate adhesive bandage and preparation method thereof

An antibacterial alginate and band-aid technology, applied in the field of medical care products, can solve problems such as cytotoxicity and adverse effects, and achieve the effects of simple ingredients, good elasticity and good safety.

Inactive Publication Date: 2020-04-07
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nano-silver antibacterial hydrogel dressing has good antibacterial effect in antibacterial repair, but too much nano-silver is easy to produce cytotoxicity to host cells such as epidermal cells and fibroblasts, and nano-silver or silver Base dressings may have adverse effects

Method used

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  • Antibacterial alginate adhesive bandage and preparation method thereof
  • Antibacterial alginate adhesive bandage and preparation method thereof
  • Antibacterial alginate adhesive bandage and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Such as figure 1 Shown, a kind of antibacterial alginate bandage is made up of adhesive layer 3, covering layer and the release paper layer covered on the adhesive layer and covering layer; Described covering layer comprises oval alginate foam Dressing 1 and the alginate non-woven fabric 2 distributed around the alginate foam dressing 1, the alginate non-woven fabric 2 is distributed in a rectangular shape, and the alginate foam dressing 1 and the alginate non-woven fabric 2 are in the same Horizontally; oval alginate foam dressing 1 and the surface layer of the wound dressing contain lysozyme. Adhesive layer 3 is an elastic cloth tape coated with a medical acrylic glue layer; the release paper layer is zinc silicon oil paper; it is covered on the adhesive layer and the core layer, and the release paper layer is uncovered during use, and the oval algae Acid foam dressing is aimed at the wound, and the adhesive layer is fixed on the intact skin around the wound by strok...

Embodiment 2

[0033] Such as figure 1 Shown, a kind of antibacterial alginate bandage is made up of adhesive layer 3, covering layer and the release paper layer covered on the adhesive layer and covering layer; Described covering layer comprises oval alginate foam Dressing 1 and the alginate non-woven fabric 2 distributed around the alginate foam dressing 1, the alginate non-woven fabric 2 is distributed in a rectangular shape, and the alginate foam dressing 1 and the alginate non-woven fabric 2 are in the same Horizontally; oval alginate foam dressing 1 and the surface layer of the wound dressing contain lysozyme. Adhesive layer 3 is an elastic cloth tape coated with a medical acrylic glue layer; the release paper layer is zinc silicon oil paper; it is covered on the adhesive layer and the core layer, and the release paper layer is uncovered during use, and the oval algae Acid foam dressing is aimed at the wound, and the adhesive layer is fixed on the intact skin around the wound by strok...

Embodiment 3

[0043]The single-side lysozyme-containing alginate foam dressing prepared by the present invention was tested for its antibacterial performance.

[0044] Take one strain from the preserved bacteria and streak it on nutrient agar, culture it at 37°C for 24 hours, take one strain and inoculate it in 20mL of nutrient broth, culture it with shaking at 130r / min at 37°C for 18 hours, wash it with PBS buffer (0.03 mol / L ) diluted to a viable count of 1×10 9 CFU / mL~5×10 9 CFU / mL, prepare the bacterial suspension for later use. Weigh 1g sample, cut it into pieces and put it into a flask, add 95mL PBS buffer solution (0.03 mol / L) and stir evenly, and set up a blank control. Take 5mL of the bacterial suspension and add it to the flask, shake it evenly at a constant temperature, and immediately take 1mL and make four 10-fold gradient dilutions with PBS. Take 200 microliters of the fourth diluted bacterial suspension and spread it on the culture medium, and incubate it upside down at a ...

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Abstract

The invention relates to a medical care product, in particular to an antibacterial alginate adhesive bandage and a preparation method thereof. The adhesive bandage comprises an adhesive layer, a dressing core layer and a release paper layer, wherein the dressing core layer comprises an oval alginate foam dressing and an alginate non-woven fabric distributed around the alginate foam dressing; the oval alginate foam dressing is prepared through a freeze-drying process without addition of a cross-linking agent, and has a pH value of 5.0 to 6.0; the surface layer of the face, attached to a wound,of the oval alginate foam dressing contains lysozyme. The alginate adhesive bandage is convenient to use, waterproof and breathable and provides a wet healing environment for a wound surface; the surface, in contact with the wound, of the alginate foam dressing of the dressing core layer contains lysozyme, so the dressing core layer has antibacterial and anti-inflammatory effects, exerts certain pressure on the wound and can accelerate hemostasis; and the alginate foam dressing of the dressing core layer is not added with any cross-linking agent, so the adhesive bandage is simple in composition and good in safety.

Description

technical field [0001] The invention relates to medical care products, in particular to an antibacterial alginate wound dressing and a preparation method thereof. Background technique [0002] Traditional wound care bandage products are mainly made of gauze and cotton, and only focus on the absorption of exudate. Dry traditional dressings can play a role in monitoring and covering wounds, but they cannot be used for infected wounds and have no effect on wound healing. Facilitating effect, a large amount of wound moisture is absorbed, and the ability to manage exudate is limited, which can easily lead to dehydration of wound tissue, limit the growth of granulation tissue and regeneration of connective tissue, adhere to the wound, cause re-injury to the new epithelial tissue and cause bleeding, and cause pain after the patient changes the dressing. With the development and maturity of moist healing theory, a series of new dressings have been developed, which can not only absor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/38A61L15/42A61L15/44A61L15/46A61F13/02A61F13/00
CPCA61F13/02A61F13/0263A61F13/0289A61F13/00063A61L15/46A61L15/38A61L15/42A61L15/28A61L15/44A61L2300/254A61L2300/404A61L2300/41A61F13/01029C08L5/04
Inventor 卢亢何立彬吴俊凤
Owner GUANGDONG TAIBAO MEDICAL SCI TECH