Micro-needle pressing type electrochemical sensor based on mobile phone platform

Abstract

The invention relates to the field of biomedical engineering, and discloses a micro-needle pressing type electrochemical sensor based on a mobile phone platform. The electrochemical sensor comprises apressing micro-needle sensor device with a reverse iontophoresis function and a three-electrode electrochemical detection function, and a hardware interface circuit for carrying out Bluetooth data exchange with a mobile phone, wherein the hardware interface circuit is connected with a circuit of the sensor device. According to the invention, a micro-needle punctures a skin to extract biomarkers by reverse electroosmosis, so that detection sensitivity is improved; and loss of bioidentification molecules can be prevented, so that a maximum utilization rate of the bioidentification molecules inin-vivo detection can be realized, and meanwhile, an intelligent detection process can be realized. The invention also provides a detection system of the micro-needle pressing type electrochemical sensor based on the mobile phone platform.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a microneedle pressing electrochemical sensor based on a mobile phone platform. Background technique [0002] Some biomarkers in human interstitial fluid have been shown to reflect human health status, so reliable and convenient non-invasive or minimally invasive monitoring of these markers will have a major impact on various healthcare and health applications. Currently, existing detection methods include optical measurements (such as infrared spectroscopy, Raman spectroscopy, optical coherence tomography, and fluorescence), indirect measurements (metabolic heat, impedance, and polarization changes), and electrochemical detection. Among them, optical measurement is easily disturbed by confounding factors, and indirect measurement lacks specificity for markers, while electrochemical detection technology has the advantages of high sensitivity, simple pretreatment, good reliab...

AI Technical Summary

Problems solved by technology

However, the modified biorecognition molecules are easy to fall off due to friction during the process of microneedle penetration into the skin barrier, resulting in the microneedle array entering the body cannot achieve the purpose of in vivo electrochemical detection

[0004] Moreover, the detection of biomarkers usually requires the use of desktop instruments and professional operations, which is not conducive to family medicine and personal health monitoring

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