Vertebral body reinforced calcium phosphate bone cement and preparation method thereof

Abstract

The invention discloses vertebral body reinforced calcium phosphate bone cement, which has good compressive strength, collapse resistance and osteogenesis induction effect, and can avoid pulmonary embolism caused by collapse in vertebroplasty. The technical scheme of the invention is as follows: the calcium phosphate bone cement comprises solid-phase powder and curing liquid; the solid-phase powder comprises the following components in parts by weight: 90-100 parts of calcium phosphate powder, 5-10 parts of absorbable fibers, 10-20 parts of bone morphogenetic protein-loaded quaternary ammoniumsalt-73 bentonite and 10-30 parts of a developing agent; and the curing liquid comprises the following component in parts by weight: 20-40 parts of a buffer solution. Bentonite is modified by using low-concentration bone morphogenetic protein, and quaternary ammonium salt has positive ions, so that protein binding sites are formed, the bone morphogenetic protein is not easily taken away by body fluid after being combined with the bentonite, and the concentration of the bone morphogenetic protein in the bone cement is not reduced along with time. The toxicity can be reduced, the cost can be reduced, and the bone cement is suitable for wide popularization and application.

Description

technical field [0001] The invention belongs to the field of medical materials and relates to the technical field of bone cement, in particular to a vertebral body reinforced calcium phosphate bone cement and a preparation method thereof. Background technique [0002] Osteoporosis can cause degenerative diseases of the spine, characterized by damage to bone microstructure, decreased bone mass, and increased bone fragility. In the United States, it is estimated that 25% of women over 70 have spinal osteoporosis Vertebral compression fractures (OVCF), the main clinical manifestations are low back pain, limited thoracolumbar movement, and will affect the quality of life of patients. The traditional treatment methods are bed rest, drugs, orthopedic braces, calcium supplementation and other treatments. [0003] In 1987, Galibert et al. in France first reported the use of vertebroplasty (Vertebroplasty, VP) in the treatment of intractable painful C2 vertebral hemangiomas, and ach...

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Problems solved by technology

[0003] In 1987, Galibert et al. in France first reported the use of vertebroplasty (Vertebroplasty, VP) in the treatment of intractable painful C2 vertebral hemangiomas, and achieved good results. This technique has been extended and applied to benign and malignant vertebral tumors, bone Preventive treatment of loose vertebral fractures and vertebral bodies with a high risk of fracture. This technology injects PMMA bone cement into the affected vertebral body through the skin through a puncture needle to increase the strength and rigidity of the patient and prevent further vertebral body damage. Collapse can effectively relieve pain and improve the life of patients, but complications will also occur when implementing this technology

[0004] The composition of calcium phosphate bone cement is similar to that of human bone tissue. It has good biocompatibility and osteoconductivity. Low mechanical strength, inconsistent degradation rate and new bone formation rate, bone cement collapse during vertebroplasty can lead to pulmonary embolism, these defects limit its application in vertebroplasty