Molecularly imprinted silica gel polymer and preparation method and application thereof

Abstract

The invention discloses a molecularly imprinted silica gel polymer and a preparation method and application thereof, and belongs to the field of synthesis of silica gel polymers. The method comprisesthe following steps: preparing a molecularly imprinted pre-polymerization solution from a functional monomer, a cross-linking agent, template molecules and a solvent, and adding the molecularly imprinted pre-polymerization solution into a reaction container; reacting the molecularly imprinted pre-polymerization solution in the reaction container under stirring or standing conditions at room temperature to obtain a polymer, centrifuging, washing and drying to obtain a silica gel polymer containing template molecules; and removing the template molecules in the silica gel polymer containing the template molecules by using an elution solution. According to the invention, a silanization reagent containing an amino functional group is used as a functional monomer, so that adverse effects of acidic and basic catalysts on molecular imprinting are eliminated, and the selectivity and adsorption capacity of the molecularly imprinted silica gel polymer can be remarkably improved. The reaction conditions are mild, and wastewater generated by using a catalyst is reduced, so that the production cost and the wastewater treatment cost are reduced, and the product can be used for extracting, enriching and separating target template molecules.

Description

technical field [0001] The invention belongs to the synthesis field of silica gel polymers, and in particular relates to a molecularly imprinted silica gel polymer and its preparation method and application. Background technique [0002] Molecularly Imprinted Polymer (Molecularly Imprinted Polymer) is a high molecular polymer with special molecular recognition ability, known as "artificial antibody or receptor". The formation principle of the selective recognition ability of molecularly imprinted polymers is: first form a complex between template molecules and functional monomers through covalent bonds or non-covalent interactions, and then add cross-linking agents and initiators to obtain molecularly imprinted prepolymers; then , under certain conditions (such as heating or light), the polymerization reaction is initiated to obtain a high-molecular polymer; finally, the template molecules in the polymer are removed, thereby leaving an imprinted cavity complementary to the s...

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Problems solved by technology

Although molecularly imprinted silica gel polymers have the above advantages, a large amount of acidic catalysts (such as hydrochloric acid, acetic acid, etc.) or basic catalysts (such as ammonia, sodium hydroxide, etc.) Affe

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