Cefixime granules and preparation method thereof

Abstract

The invention provides cefixime granules and a preparation method thereof. The cefixime granules are prepared from the following raw materials in parts by weight: 30 to 70 parts of cefixime, 700 to 900 parts of cane sugar, 10 to 30 parts of dextrin, 30 to 70 parts of sweet orange powder essence, 30 to 70 parts of Arabic gum, 5 to 15 parts of tragacanth and 0.2 to 1.4 parts of sunset yellow. The preparation method of the cefixime granules uses a one-step granulation preparation means, an intermediate does not need to be prepared, dry granulation is efficiently used, and the raw materials are mixed at a set rotating speed for a set time, so that the granulated product is uniform in granularity, the fluidity is improved, dust flying is controlled, powder waste is reduced, and all steps in traditional granulation are combined into a whole. The operation method is simple, high in production efficiency and suitable for industrial production.

Description

technical field [0001] The invention relates to the field of medicine granulation, in particular to a cefixime granule and a preparation method thereof. Background technique [0002] Cefixime is white to pale yellow crystalline powder, odorless, with a slight specific odor, easily soluble in methanol, slightly soluble in acetone, insoluble in ethanol, almost insoluble in water, ethyl acetate, ether. Cefixime is a third-generation cephalosporin antibiotic for oral use. It has broad antibacterial spectrum and strong antibacterial activity. It is effective against Gram-negative microorganisms, Gram-negative microorganisms, Moraxella catarrhalis, E. Both Bacillus and Neisseria gonorrhoeae have good antibacterial activity, and are suitable for treating respiratory, urinary and biliary tract infections caused by sensitive bacteria. [0003] Cefixime granules generally use wet granulation process. During the production process, other solvents are often added to assist in the moldi...

AI Technical Summary

Problems solved by technology

[0003] Cefixime granules generally use wet granulation process. During the production process, other solvents are often added to assist in the molding process. During the production process, it is easy to degrade and seriously damage the stability of the granules. In addition, the cefixime raw materials are difficult to dissolve in water. If the raw materials Improper proportioning of cefixime can lead to poor physical effect and precipitation, which is also an influencing factor for the low stability of cefixime, which is not conducive to safe clinical use and long-term storage. At the same time, dry granulation often exists in the production process The particle size of the powder is different, the density is uneven, the fluidity is not good, and the characteristics of easy layering lead to a low yield of the produced cefixime granules

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