Medical degradable antibacterial composite material as well as preparation method and application thereof

Abstract

The invention discloses a medical degradable antibacterial composite material as well as a preparation method and application thereof. The composite material uses a porous magnesium alloy (6) having through holes as a reinforcement body, the holes (1) of the reinforcement body are filled with degradable polymer materials polycaprolactone and polylactic acid, and nano-magnesium oxide powder is uniformly dispersed in the degradable polymer materials. The preparation method of the composite material comprises the following steps: 1) preparing the porous magnesium alloy (6) reinforcement body; 2)mixing the nano-magnesium oxide powder, the polylactic acid and the polycaprolactone, performing mold pressing to obtain a polymer thin sheet (5); and 3) placing the polymer thin sheet (5) on the porous magnesium alloy (6), and performing extrusion and solidification to obtain the composite material. The composite material has good biocompatibility, safe, stable and controllable degradation, goodmechanical properties and an antibacterial function, is suitable for small orthopedic restoration products with various shapes, and can be used as a new generation of degradable materials to be used in bone trauma surgery, bone defect repair surgery, plastic surgery and other medical implantation fields.

Description

Technical field [0001] The invention relates to a medical degradable antibacterial composite material and a preparation method and application thereof, and belongs to the field of orthopedic medical equipment, and is particularly suitable for the field of bone trauma surgery, bone defect repair surgery, and plastic and cosmetic medical equipment. Background technique [0002] Bone repair technology is a conventional method of bone trauma surgery, bone defect repair surgery, and plastic surgery. At present, it is most commonly used clinically made of pure titanium or titanium alloy. Its stable repair effect and superior biocompatibility provide bone healing Good conditions, but it also has the following problems: (1) The elastic modulus of titanium is 8 times that of cortical bone, which has a stress shielding effect on normal bone tissue, which is easy to cause osteoporosis and fracture again; (2) It cannot be degraded and absorbed. , Need a second operation to take out, causing ...

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Problems solved by technology

[0002] Bone repair technology is a routine method for orthopedic trauma surgery, bone defect repair surgery, and plastic surgery. At present, pure titanium or titanium alloy is the most commonly used in clinical practice. Its stable repair effect and superior biocompatibility provide a solid foundation for bone tissue healing. Good conditions, but it also has the following problems: (1) The elastic modulus of titanium metal is 8 times that of cortical bone, and it has a stress shielding effect on normal bone tissue, which is easy to cause osteoporosis and re-fracture; (2) It cannot be degraded and absorbed , requiring a second operation to remove it, causing secondary damage

However, the corrosion resistance of magnesium alloys is poor, and the biodegradation rate in the human body is too fast, and the corrosion is often severe before the fracture fixation and healing are not completely stable, and the excessive corrosion degradation rate will cause a significant decrease in mechanical strength, and rapid release of large quantities Magnesium metal ions can cause bone dissolution

Although there are also research reports on improving its corrosion resistance through surface modification, the results are not ideal.

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