Preparation method of gold/graphene quantum dot/mercaptopropionic acid/polyethylenimine drug-loading hydrogel applicable to drug slow release
A technology of graphene quantum dots and polyethyleneimine, applied in the fields of material synthesis and biomedicine, can solve problems such as side effects, and achieve the effect of simple and convenient preparation process
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Embodiment 1
[0022] The preparation of gold / graphene quantum dots / mercaptopropionic acid / polyethyleneimine drug-loaded hydrogel includes the following steps:
[0023] (1) Dissolve 2 g of citric acid monohydrate in 15 mL of ultrapure water, then transfer the clear solution into a crucible, heat it in a muffle furnace at 175°C for 2 hours, take it out, and dissolve it in ultrapure water after cooling to room temperature. Become the graphene quantum dot solution that concentration is 20mg / mL for subsequent use.
[0024] (2) the chloroauric acid solution of 2mL20mg / mL and the graphene quantum dot solution that 2mL step (1) are made mix homogeneously, 5min is irradiated with ultraviolet light, centrifugation removes supernatant and promptly obtains gold / graphene quantum dot, and Prepare the gold / graphene quantum dot solution with a concentration of 1.5 mg / mL for later use; for example, the obtained gold / graphene quantum dots are washed with ultrapure water several times and centrifuged to remov...
Embodiment 2
[0028] The temperature-time response diagram of graphene quantum dots, gold / graphene quantum dots and gold / graphene quantum dots / mercaptopropionic acid / polyethylenimine drug-loaded hydrogel irradiated by near-infrared light includes the following steps:
[0029] The preparation process of graphene quantum dots, gold / graphene quantum dots, gold / graphene quantum dots / mercaptopropionic acid / polyethyleneimine drug-loaded hydrogel is the same as that of Example 1.
[0030]Graphene quantum dots, gold / graphene quantum dots, and gold / graphene quantum dots / mercaptopropionic acid / polyethyleneimine drug-loaded hydrogel were formulated into solutions with a concentration of 1.5 mg / mL, and 5 mL of the solutions were taken out and placed in In a beaker, completely immerse the temperature measuring side of the thermometer in the solution at a room temperature of 25°C, irradiate with a near-infrared laser with a wavelength of 808nm and a power of 1W at a distance of 2cm from the beaker, and re...
Embodiment 3
[0033] The in vitro drug release of gold / graphene quantum dots / mercaptopropionic acid / polyethyleneimine drug-loaded hydrogel at different pH values at 37°C includes the following steps:
[0034] The preparation process of gold / graphene quantum dots / mercaptopropionic acid / polyethyleneimine drug-loaded hydrogel is the same as that of Example 1.
[0035] (1) Weigh 20 mg of gold / graphene quantum dots / mercaptopropionic acid / polyethyleneimine drug-loaded hydrogel, place them in dialysis bags, and place the dialysis bags in 30 mL of phosphate buffer solutions with different pHs, The drug was released in vitro by magnetic stirring at a temperature of 37° C., and the pH of the phosphate buffer solution was 5.0, 6.2 and 7.4 respectively, and the drug was released for 12 hours.
[0036] (2) Take a sample every 1 hour, take out 3mL solution for each sample, measure the amount of released cytarabine, and supplement 3mL fresh phosphate buffer solution at the same time, use a UV spectropho...
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