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Hydrogel capable of releasing nitric oxide and preparation method thereof

A technology of nitric oxide and hydrogel, applied in medical science, bandages, etc., can solve the problems of short action time, high power density damage to surrounding healthy tissues, and high frequency of administration, so as to promote healing, promote collagen deposition, and be good The effect of biocompatibility

Active Publication Date: 2020-05-19
BEOGENE BIOTECH GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently developed antibacterial nanoparticle (such as nanosilver) solution is difficult to stay on the wound for a long time due to its liquid state, short action time, high frequency of administration, high power density and long-term exposure to near-infrared lasers may damage the surrounding area. health organization

Method used

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  • Hydrogel capable of releasing nitric oxide and preparation method thereof
  • Hydrogel capable of releasing nitric oxide and preparation method thereof
  • Hydrogel capable of releasing nitric oxide and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0041] A preparation method for releasing nitric oxide hydrogel as an embodiment of the present invention, the method comprises the following steps:

[0042] (1) The 2-methylimidazole of 35.48g and the zinc acetate of 2g are dissolved in 200ml deionized water to obtain the mixed aqueous solution of 2-methylimidazole and zinc acetate, the mixed aqueous solution of 2-methylimidazole and zinc acetate at 20 Stirring and reacting at 700 rpm at ~30°C for 5 hours, collecting the reaction solution, centrifuging at 8000 rpm for 20 minutes, collecting the precipitate, washing the precipitate with deionized water, and freeze-drying to obtain the first nanoparticle (ZIF-8);

[0043] (2) Dissolve 200 mg of the first nanoparticles and 100 mg of N, N'-di-sec-butyl-N, N'-dinitroso-1,4-phenylenediamine (BNN6) in 30 mL with a volume fraction of 40% After stirring at 700rpm / min in aqueous ethanol solution for 24h to obtain solution A, add 60mg of dopamine hydrochloride and 0.26mL of 1M sodium hy...

Embodiment 2

[0049] As a preparation method of nitric oxide releasing hydrogel in the embodiment of the present invention, the only difference between this embodiment and embodiment 1 is that in step (3), 1.0 mg of the second nanoparticle (BZP), 50 mg Methacrylated gelatin (GelMA) and 12.5 mg oxidized dextran (oDex) were uniformly dispersed in 1 mL of PBS solution to obtain the mixed system B.

Embodiment 3

[0051] As a preparation method of nitric oxide releasing hydrogel in the embodiment of the present invention, the only difference between this embodiment and embodiment 1 is that in step (3), 1.0 mg of the second nanoparticle (BZP), 50 mg Methacrylated gelatin (GelMA) and 25 mg oxidized dextran (oDex) were uniformly dispersed in 1 mL of PBS solution to obtain the mixed system B.

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Abstract

The invention provides hydrogel capable of releasing nitric oxide and a preparation method of the hydrogel. The preparation method comprises the following steps: (1) carrying out a stirring reaction on a mixed aqueous solution of 2-methylimidazole and zinc acetate at 20-30 DEG C, carrying out centrifuging, and collecting precipitates to obtain first nanoparticles; (2) dispersing the first nanoparticles and N,N'-di-sec-butyl-N,N'-dinitroso-1,4-phenylenediamine in an ethanol aqueous solution, carrying out stirring, adding dopamine hydrochloride and sodium hydroxide, carrying out stirring at 20-30 DEG C, carrying out reacting, and collecting precipitates to obtain second nanoparticles; and (3) uniformly dispersing the second nanoparticles, methacrylated gelatin and dextran oxide in a PBS solution, adding a photoinitiator, and initiating cross-linking under light with a wavelength of 365-760 nm to obtain the hydrogel capable of releasing nitric oxide. The hydrogel capable of releasing nitric oxide prepared by the method has good biocompatibility, and can significantly promote healing of full-thickness injury wounds, promote collagen deposition and inhibit bacterial growth.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a nitric oxide releasing hydrogel and a preparation method thereof. Background technique [0002] Bacterial infection is a very common problem in open wounds. With the discovery and application of antibiotics, bacterial infection has been effectively suppressed. However, long-term use of antibiotics may lead to drug resistance in some bacteria, greatly reducing the treatment effect of infection. Photothermal therapy has attracted extensive attention in recent years because of its broad-spectrum antibacterial effect, which can kill bacteria by generating local high temperature generated by photosensitizers under near-infrared (NIR) light radiation. The currently developed antibacterial nanoparticle (such as nanosilver) solution is difficult to stay on the wound for a long time due to its liquid state, short action time, high frequency of administration, high power densi...

Claims

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Application Information

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IPC IPC(8): C08H1/00C08B37/02A61L26/00
CPCA61L26/0052A61L26/0066A61L26/008A61L26/009A61L2300/114A61L2300/404A61L2300/412A61L2300/604C08B37/0009C08B37/0024C08H1/00C08L89/00C08L5/02
Inventor 蓝咏冯龙宝刘玉
Owner BEOGENE BIOTECH GUANGZHOU
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