Antibacterial piezoelectric Mxene composite material and application thereof

A composite material and piezoelectric material technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve problems such as elastic modulus mismatch, poor biocompatibility, dimensional instability, etc., and achieve mild synthesis conditions and porosity. The effect of promoting proliferation, differentiation and cell adhesion

Inactive Publication Date: 2020-05-22
GUANGDONG UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Major diseases and accidents will cause irreparable damage to human bones, so it is necessary to replace or transplant new bones or external objects. Common bone substitutes have disadvantages such as poor biocompatibility, mismatching elastic modulus, and unstable size. , It is easy to cause normal bone degeneration, inflammation, bacterial infection and secondary surgery and other sequelae

Method used

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  • Antibacterial piezoelectric Mxene composite material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Preparation: 1g of Ti 3 C 2 Add 1g sodium potassium lithium niobate (particle size is 20nm) and carry out hydrothermal reaction at 40°C for 5h, on Ti 3 C 2 In situ polymerization to obtain nanometer sodium potassium lithium niobate, after separation and purification, soak in 200mL of 1.5mol / L doxorubicin DMF solution for 3h, wash with 95% absolute ethanol three times, and then wash with acetone solution Three times, vacuum drying at 40 °C to obtain Ti 3 C 2 composite material.

[0026] 2. Performance test: obtained Ti 3 C 2 Composite materials due to nano-Na-K-Li piezoelectric material and Ti 3 C 2 Co-doped materials to exert their respective properties, so as to have antibacterial and piezoelectric properties at the same time. With antibacterial piezoelectric Ti 3 C 2 The composite material is cultured with somatic osteoblasts under the action of external stress to increase the concentration of cells on the surface by 30.5%, and the drug release of doxoru...

Embodiment 2

[0029] 1. Preparation: 0.5 g of Ta 4 C 3 Add 10g lithium niobate (particle size is 25nm), in Ta 4 C 3 In situ polymerization to obtain nano-lithium niobate, after separation and purification, soak in 150mL of 2.5mol / L quinolone in dichloromethane solution for 4.5h, rinse with 95% absolute ethanol three times, and then wash three times with acetone solution , vacuum-dried at 40°C, the antibacterial piezoelectric Ta 4 C 3 composite material.

[0030] 2. Performance test: the obtained piezoelectric Ta with antibacterial properties 4 C 3 The composite material is cultured with somatic osteoblasts under stress to increase the concentration of cell proliferation and differentiation on the surface by 35.8%. The release of quinolone drugs is stable and long-lasting, and the content of 55.3% can still be maintained after 30 hours of continuous release.

Embodiment 3

[0032] 1. Preparation: 0.1 g of Nb was prepared by co-precipitation 4 C 3 Add 10g potassium niobate (particle size is 40nm), in Nb 4 C 3 Nano potassium niobate was obtained by in-situ polymerization. After separation and purification, soak in 250 mL of 1mol / L penicillin phosphate buffer for 5 hours, wash with 95% absolute ethanol three times, and then wash with acetone solution for three times. Vacuum at 40°C dried to produce piezoelectric Nb with antimicrobial properties 4 C 3 composite material.

[0033] 2. Performance test: the obtained piezoelectric Nb with antibacterial properties 4 C 3 The composite material is cultured with somatic osteoblasts under stress to increase the concentration of cell proliferation and differentiation on the surface by 22.6%, and the release of penicillin is stable and long-lasting, and the content of 33.6% can still be maintained after 36 hours of continuous release.

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Abstract

The invention belongs to the technical field of tissue engineering biomedical applications, and discloses an antibacterial piezoelectric Mxene composite material and an application thereof. The composite material is obtained by the steps of adding Mxene into a nano niobate, loading the nano niobate on the surface of the Mxene in situ to obtain an Mxene composite piezoelectric material, soaking theMxene composite piezoelectric material in a solvent containing an antibacterial drug, and performing vacuum drying at 40-80 DEG C to obtain the composite material, wherein the Mxene is M<n+1>X<n>T<x>, n = 1 to 3, X is C or N, M is a transition metal element selected from Sc, Ti, Zr, Hf, V, Nb, Ta, Cr, Mo and Mn, T<x> represents a surface functional group, and the surface functional group is -O, -OH or -F. The Mxene composite material provided by the invention has large porosity, and has the characteristics of promoting formation of calcium and phosphate salts on the surface of an implant, promoting proliferation and differentiation of bone cells and cell adhesion under the action of external pressure, and having good biocompatibility and a simple preparation method.

Description

technical field [0001] The invention belongs to the technical field of biomedical tissue engineering, and more specifically relates to an antibacterial piezoelectric Mxene composite material and its application. Background technique [0002] Major diseases and accidents will cause irreparable damage to human bones, so it is necessary to replace or transplant new bones or external objects. Common bone substitutes have disadvantages such as poor biocompatibility, mismatching elastic modulus, and unstable size. , It is easy to cause normal bone degeneration, inflammation, bacterial infection and secondary surgery and other sequelae. [0003] Antibacterial materials need to have high porosity, be interconnected, be biocompatible and degradable, and be able to be excreted after the release of antibacterial drugs. As a new type of two-dimensional material, Mxene has a large interlayer spacing and a very large specific surface area. It is an excellent carrier of antibacterial drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/50A61L27/54A61L27/56
CPCA61L27/025A61L27/50A61L27/54A61L27/56A61L2300/404A61L2300/406A61L2430/02
Inventor 闵永刚刘荣涛朋小康张诗洋黄兴文王勇刘屹东廖松义
Owner GUANGDONG UNIV OF TECH
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