Fucoidan-based theragnostic Composition

Abstract

The present invention relates to a fucoidan-based theragnostic composition, and more particularly, to preparation and use of a theragnostic composition which uses a conjugate of a fluorescent dye or aphotosensitizer and fucoidan, thereby not only allowing for fluorescence imaging diagnosis of lesions for cancer or vascular diseases but also allowing a therapeutic effect thereon to be obtained atthe same time. The conjugate obtained by covalent bonding of a fluorescent dye or a photosensitizer and fucoidan, according to the present invention, is not only useful for fluorescence imaging diagnosis of tumor tissues and ophthalmic vascular diseases, but also may exhibit a therapeutic effect on cancer cells and coronary artery smooth muscle cells, and a neovascularization inhibitory effect inophthalmic diseases. In addition, in a case where photodynamic therapy is further implemented on the conjugate according to the present invention, cancer and vascular diseases may be effectively treated with low adverse effects.

Description

Technical field [0001] The present invention relates to a fucoidan-based diagnostic and therapeutic agent (theragnostic) composition, more specifically, the present invention relates to the preparation and use of a diagnostic and therapeutic agent composition, by using a fluorescent dye or a photosensitizer and fucoidan to covalently The combined conjugate not only enables fluorescent imaging diagnosis of cancer or vascular disease lesions, but also obtains therapeutic effects at the same time. Background technique [0002] Diagnosis and treatment are the two main categories in the clinical application of diseases. Recently, the concept of diagnosis and treatment has been introduced that uses the imaging function of therapeutic agents to simultaneously diagnose and treat. [0003] The photosensitizer used in photodynamic therapy (PDT) has the characteristics of absorbing light of a specific wavelength and generating a fluorescent signal. It has the advantage of using it for the flu...

AI Technical Summary

Problems solved by technology

However, although this hydrophilic polymer-photosensitizer and conjugate are helpful for improving the hydrophilicity of the photosensitizer, they do not have specific targeting to cancer cells or cells related to other diseases. Therefore, in order to Targeting cells is specific and must bind target ligands such as folic acid or antibodies or aptamers to the polymer in one step

In this case, the steps and costs required for the preparation increase, and the mass production of the conjugate is difficult

Moreover, although the hydrophilic polymer accounts for more than 70% of the mass in the hydrophilic polymer and photosensitizer conjugate, the therapeutic effect is only obtained by means of the photosensitizer, and the hydrophilic polymer itself has no treatment for cancer cells, etc. effect, thus having the great disadvantage that not only is the therapeutic effect achievable in relation to the mass low, but also that the photodynamic therapy effect cannot be obtained in the absence of light reaching the site of delivery of the polymer-photosensitizer conjugate

[0006] In addition, attempts have been made to use conjugates of fluorescent dyes that bind ligands that can target specific cells and hydrophilic polymers (i.e., ligand-fluorescent dye-hydrophilic polymer conjugates) to treat cancer and other lesions. Imaging diagnosis, in this case, only the imaging diagnosis function of the target site can be obtained, and in order to obtain the therapeutic effect, it is necessary to go through a complicated process of further binding or loading the drug on the polymer

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