Preparation method of HAP/PLA composition bone repair stent loaded with strontium ranelate

A technology of strontium ranelate and composite materials, which is applied in the field of preparation of scaffold materials for bone repair, can solve the problems such as extruded PLA wires, which are rarely reported, and achieve high hardness, good antibacterial properties, and the effect of inhibiting bone resorption

Inactive Publication Date: 2020-05-29
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although PLA filaments have been successfully applied in the FDM process, reports on the detailed extrusion of PLA filaments are rarely reported.

Method used

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  • Preparation method of HAP/PLA composition bone repair stent loaded with strontium ranelate
  • Preparation method of HAP/PLA composition bone repair stent loaded with strontium ranelate
  • Preparation method of HAP/PLA composition bone repair stent loaded with strontium ranelate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation method of a HAP / PLA composite material bone repair support loaded with strontium ranelate is carried out as follows:

[0024] 1) Fully mix nano-scale hydroxyapatite powder, medical-grade PLA plastic particles and strontium ranelate powder to obtain a mixed raw material; in the mixed raw material, nano-sized hydroxyapatite powder, medical-grade PLA plastic, and strontium ranelate powder The mass ratio of the mixture is 10:90:1; nano-sized hydroxyapatite powder and strontium ranelate powder are respectively passed through a 200-mesh sieve before mixing. The medical grade PLA particles are preferably L-polylactic acid particles. The raw materials were added to the internal mixer and mixed for 15 minutes at 200°C.

[0025] 2) Melt and extrude the mixed raw materials into wires through a single-screw extruder to obtain HAP / PLA wires doped with strontium ranelate for 3D printing. The diameter of the wires is controlled at 1.75mm; the single-screw extruder The ...

Embodiment 2

[0029] A preparation method of a HAP / PLA composite material bone repair support loaded with strontium ranelate is carried out as follows:

[0030] 1) Fully mix nano-scale hydroxyapatite powder, medical-grade PLA plastic particles and strontium ranelate powder to obtain a mixed raw material; in the mixed raw material, nano-sized hydroxyapatite powder, medical-grade PLA plastic, and strontium ranelate powder The mass ratio of the mixture is 9:92:1; nano-sized hydroxyapatite powder and strontium ranelate powder are respectively passed through a 200-mesh sieve before mixing.

[0031] 2) Melted and extruded into filaments by a single-screw extruder to obtain HAP / PLA wires doped with strontium ranelate for 3D printing, the diameter of the wires is controlled at 1.70-1.80mm; the melting temperature of the single-screw extruder 180~190℃.

[0032] 3) On the FDM fusion printer, after importing the designed three-dimensional model of the bone repair scaffold, print with the wire obtaine...

Embodiment 3

[0035] A preparation method of a HAP / PLA composite material bone repair support loaded with strontium ranelate is carried out as follows:

[0036] 1) Fully mix nano-scale hydroxyapatite powder, medical-grade PLA plastic particles and strontium ranelate powder to obtain a mixed raw material; in the mixed raw material, nano-sized hydroxyapatite powder, medical-grade PLA plastic, and strontium ranelate powder The mass ratio of the mixture is 11:88:1; nano-sized hydroxyapatite powder and strontium ranelate powder are respectively passed through a 200-mesh sieve before mixing.

[0037] 2) Melted and extruded into filaments by a single-screw extruder to obtain HAP / PLA wires doped with strontium ranelate for 3D printing. The diameter of the wires is controlled at 1.70-1.75mm; the melting temperature of the single-screw extruder is 180°C.

[0038] 3) On the FDM fusion printer, after importing the designed three-dimensional model of the bone repair scaffold, print with the wire obtain...

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Abstract

The invention discloses a preparation method of an HAP / PLA composition bone repair stent loaded with strontium ranelate in the technical field of medical orthopedic materials. Nano hydroxyapatite powder, medical-grade PLA plastic particles and strontium ranelate powder are fully mixed to obtain a mixed raw material; and the mixed raw material is subjected to melt extrusion by a screw extruder to form filaments to obtain an HAP / PLA wire rod doped with the strontium ranelate for 3D printing, and the wire rod is printed on an FDM melting type printer to obtain the HAP / PLA composition bone repairstent doped with the strontium ranelate. The obtained bone repair stent has high strength, high hardness and high impact strength, has good antibacterial property and good biocompatibility, can be degraded and absorbed by the human body, reduces the probability of inflammation at bone defect parts and is a good choice for an implant material, due to the duality of the loaded strontium ranelate drug, bone absorption can be inhibited while osteogenesis is promoted, and repair of bone defect parts is accelerated.

Description

technical field [0001] The invention belongs to the technical field of medical orthopedic materials, in particular to a method for preparing a 3D printed bone repair scaffold material. Background technique [0002] Osteoporosis is due to the decreasing bone mass and the destruction of bone tissue microarchitecture, which leads to increased bone fragility and increased risk of fracture, and it often occurs in the elderly and postmenopausal women. The disease usually directly affects the bones of the whole body, and fracture is the most common complication of osteoporosis, often causing fractures of the wrist, spine and medullary bone. With the deteriorating daily aging population in our country, the number of osteoporosis patients is gradually increasing. Therefore, it is necessary to use safe and effective drugs for the prevention and treatment of osteoporosis. Strontium ranelate (Strontium ranelate) chemical name is 5-[di(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thi...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/54A61L27/58B29C64/118B29C48/05B33Y10/00B33Y70/00B33Y70/10D01F1/10D01F6/92
CPCA61L27/46A61L27/54A61L27/58A61L2300/216A61L2300/404A61L2300/412A61L2430/02B33Y10/00B33Y70/00B29C64/118B29C48/022B29C48/05D01F1/10D01F6/92C08L67/04
Inventor 朱沛志梅海波
Owner YANGZHOU UNIV
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