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Composite material and preparation method and application thereof, and method for detecting 3, 4-dihydroxyphenylacetic acid

A technology of dihydroxyphenylacetic acid and composite materials, which is applied in the chemical field and can solve problems that need to be improved

Active Publication Date: 2020-06-02
CAPITAL NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In related technologies, there has not been a composite material that can simultaneously remove a variety of reactive oxygen species in cells; Active oxygen can also better catalyze the oxidation of 3,4-dihydroxyphenylacetic acid composite materials, which makes it impossible to use the same material to achieve the above multiple purposes, which in turn makes it impossible to use the same material to prevent oxidative stress and detect in vivo Physiological activity information
[0003]Therefore, the related technologies of existing composite materials still need to be improved

Method used

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  • Composite material and preparation method and application thereof, and method for detecting 3, 4-dihydroxyphenylacetic acid
  • Composite material and preparation method and application thereof, and method for detecting 3, 4-dihydroxyphenylacetic acid
  • Composite material and preparation method and application thereof, and method for detecting 3, 4-dihydroxyphenylacetic acid

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The method for preparing the composite material and the prepared composite material:

[0067] Dissolve 5g of 2-methylimidazole in 19mL of water, stir until transparent, then add 0.2mL of a mixed alcohol solution containing 0.0456g of PVP (the volume ratio of methanol, ethanol, and isopropanol is 1:1:1) , and finally 0.2925g of Co(NO 3 ) 2 ·6H 2 O was dissolved in 1mL of water and added to the above solution, the solution immediately turned blue-purple, and stirred at room temperature for 4h. After the reaction was finished, it was washed twice with ethanol, and dried at 60° C. to obtain ZIF-67 grains.

[0068] 58 mg of the ZIF-67 crystal grains obtained above are taken and dissolved in 10 mL of ethanol solution, and 5 mL contains 25 mg Cu (NO 3 ) 2 ·3H 2 The ethanol solution of O was injected into it, and then the mixed solution was moved to a 20mL hydrothermal reaction kettle, and reacted at 120°C for 4h. After the reaction was completed, it was washed with ethan...

Embodiment 2

[0086] Detect the method of 3,4-dihydroxyphenylacetic acid content in the sample to be tested:

[0087] The concentration of the composite dispersion was fixed at 500 μg / mL, and DOPAC was detected using an electrochemical online detection platform.

[0088] An electrochemical online detection platform is constructed by using a syringe pump, two syringes, microdialysis tubing, and an electrochemical flow cell. The dispersion of the composite material with a fixed concentration of 500 μg / mL in one syringe, and the DOPAC standard solution with a concentration of 0.5, 1 μM, 2 μM, 5 μM, 7 μM, 10 μM, 15 μM, and 20 μM in the other syringe, were real-time analyzed using an electrochemical flow cell. Record the reduction current when standard solutions with different concentrations are connected to the electrochemical online detection platform. refer to Figure 7 In Figure A, the illustration shows the linear relationship between the concentration of DOPAC and the reduction current v...

Embodiment 3

[0094] The method for preparing the composite material and the prepared composite material:

[0095] Dissolve 5g of 2-methylimidazole in 19mL of water, stir until transparent, then add 0.2mL of a mixed alcohol solution containing 0.0456g of PVP (the volume ratio of methanol, ethanol, and isopropanol is 1:1:1) , and finally 0.2925g of Co(NO 3 ) 2 ·6H 2 O was dissolved in 1mL of water and added to the above solution, the solution immediately turned blue-purple, and stirred at room temperature for 4h. After the reaction was finished, it was washed twice with ethanol, and dried at 60° C. to obtain ZIF-67 grains.

[0096] 24 mg of the ZIF-67 crystal grain obtained above is taken and dissolved in 10 mL of ethanol solution, and 5 mL contains 59 mg Cu (NO 3 ) 2 ·3H 2 The ethanol solution of O was injected into it, and then the mixed solution was moved to a 20mL hydrothermal reaction kettle, and reacted at 120°C for 4h. After the reaction was completed, it was washed with ethanol...

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Abstract

The invention provides a composite material and a preparation method and application thereof, and a method for detecting 3, 4-dihydroxyphenylacetic acid. The composite material comprises: ZIF-67 crystal grains, and a cobalt copper oxide attached to at least a portion of an outer surface of the ZIF-67 crystal grains. The composite material has good feasibility of simultaneously removing various active oxygen in cells, can well catalyze oxidation of 3, 4-dihydroxyphenylacetic acid, and is high in stability, and the established method for detecting the 3, 4-dihydroxyphenylacetic acid is wide in linear range, low in detection limit, high in sensitivity and good in application prospect.

Description

technical field [0001] The invention relates to the technical field of chemistry, in particular to a composite material, a preparation method and application thereof, and a method for detecting 3,4-dihydroxyphenylacetic acid. Background technique [0002] In related technologies, there has not been a composite material that can simultaneously remove multiple active oxygen species in cells; further, there has not been a composite material that can simultaneously remove various active oxygen species in cells and can better catalyze 3,4-dihydroxybenzene A composite material oxidized by acetic acid, which makes it impossible to use the same material to achieve the above multiple purposes, which in turn makes it impossible to use the same material to prevent oxidative stress and detect physiological activity information in vivo. [0003] Therefore, the related technologies of the existing composite materials still need to be improved. Contents of the invention [0004] The pre...

Claims

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Application Information

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IPC IPC(8): B01J31/28B01J31/22G01N1/38G01N21/33G01N27/416
CPCB01J31/28B01J31/1691B01J31/1815B01J31/003G01N27/416G01N21/33G01N1/38B01J2531/845B01J35/33
Inventor 林雨青李凯刘佳张望彭美红任国圆
Owner CAPITAL NORMAL UNIVERSITY
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