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Application of traditional Chinese medicine composition in preparation of drug for preventing and treating novel coronavirus and liver injury

A coronavirus and composition technology, applied in the field of medicine, can solve problems such as life and health hazards of patients, achieve the effects of improving the cure rate, reducing serum transaminases, and improving liver function

Active Publication Date: 2020-06-05
雷允上药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no effective treatment drug for the new coronavirus SARS-CoV-2 on the market, which brings great harm to the life and health of patients

Method used

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  • Application of traditional Chinese medicine composition in preparation of drug for preventing and treating novel coronavirus and liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of Chinese medicine composition:

[0023] (1) The preparation method of the traditional Chinese medicine composition is as follows: take 833.3 parts of Caulis sinensis and 833.3 parts of Spring Bupleurum in parts by weight and add 10 times the amount of water, steam distillation and extraction for 2 hours, collect the oil layer, the aqueous solution and the medicine residue after distillation , With 266.7 parts of Sophora flavescens and 625 parts of Daqing Ye, add 10 times the amount of medicinal material to decoct and extract twice, 1 hour each time, combine the decoction and concentrate, add ethanol to refrigerate, filter, recover ethanol, and add appropriate amount Water, refrigerate and filter to obtain the extract;

[0024] (2) Take 333.3 parts of rhubarb, add 8 times the amount of water, decoct and extract twice, 1 hour each time, combine the decoction and concentrate, add ethanol to refrigerate, filter, recover ethanol, add appropriate amount of water, ref...

Embodiment 2

[0026] Example 2 In vitro antiviral activity experiment of traditional Chinese medicine composition against common coronavirus HcoV-229E and 2019 new coronavirus SARS-Cov-2

[0027] 1. Experimental method

[0028] 1.1. VERO E6 cell (African green monkey kidney cell line) toxicity test (MTT method)

[0029] The 96-well plate monolayer cells were washed once with PBS, the supernatant was discarded, and 100 μL of the extract of the traditional Chinese medicine composition of Example 1 diluted in two-fold gradient was added to each well. Add an equal volume of culture medium to each well of the blank control group and normal cell group, at 34°C, 5% CO 2 Cultivate for 2-5d under conditions. Subsequently, 20 μL of MTT solution with a concentration of 5 mg / mL was added to each well, and the incubation continued for 4 hours. Discard the supernatant, add 100 μL DMSO to each well, and shake at low speed for 5 minutes to fully melt the crystals. Measure the absorbance value on a 490nm enzyme...

Embodiment 3

[0037] ○Example 3 Observation on the curative effect of anti-new coronavirus liver injury

[0038] 1. Case selection:

[0039] A collection of 20 confirmed cases of new coronavirus (SARS-CoV-2) (10 males and 10 females, aged 27-67 years, average age 51±1.5 years), all of them tested positive for 2019-nCoV nucleic acid, of which 14 cases Mild symptoms, 6 cases of mild symptoms. CT of 20 patients showed patchy ground glass shadows under the pleura of both lungs, thickened texture of both lungs, and enlarged liver. Biochemical indicators showed serum transaminase (ALT higher than 180U / L, AST higher than 210U / L) and increased bilirubin (higher than 60μmol / L), lymphocytes and lymphocyte percentages were significantly lower than normal, blood oxygen Level 70 to 90%.

[0040] 2. Treatment methods:

[0041] In addition to basic oxygen supply and vital signs nutritional maintenance treatment, 20 cases were given orally the granules prepared in Example 1 of the present invention, 2 bags (4 g...

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Abstract

The invention discloses application of a traditional Chinese medicine composition in preparation of a drug for preventing and treating novel coronavirus and liver injury. The intervention effect of the traditional Chinese medicine composition on the novel coronavirus (SARS-CoV-2) is screened, it is shown through screening experiments that the provided traditional Chinese medicine composition has acertain resistant effect on the novel coronavirus (SARS-CoV-2), transaminase and bilirubin in the serum of patients with the novel coronavirus (SARS-CoV-2) can be reduced significantly, the liver function can be improved, treatment of the novel coronavirus and the liver injury caused by the novel coronavirus can be assisted, clinical symptoms can be improved significantly, and the cure rate is improved.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to the application of the traditional Chinese medicine composition in the preparation of drugs for the treatment of novel coronavirus combined with liver injury, and belongs to the technical field of medicine. Background technique [0002] On February 11, the International Committee on Taxonomy of Viruses (ICTV) announced the official name of the new coronavirus as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [0003] The symptoms of pneumonia infection caused by the new coronavirus include general symptoms, severe symptoms, and atypical symptoms. The general symptoms are mainly fever, fatigue, dry cough, and gradually difficulty breathing. Severe symptoms include blood clotting dysfunction, which is difficult to correct Metabolic acidosis, septic shock, acute respiratory distress syndrome, etc., atypical symptoms, such as anorexia, fatigue, poor spirits, nause...

Claims

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Application Information

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IPC IPC(8): A61K36/855A61K36/708A61P31/14A61P11/00A61P1/16
CPCA61K36/282A61K36/233A61K36/489A61K36/708A61K36/855A61K36/704A61K36/315A61K36/195A61P31/14A61P11/00A61P1/16A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 张丹丹王恒斌潘耀宗张邦国李全罗年翠曹泽庆翟云良
Owner 雷允上药业集团有限公司
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