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Enrofloxacin chitosan nanoparticles

A technology of chitosan nanoparticles and enrofloxacin, which is applied in the field of enrofloxacin chitosan nanoparticles, can solve the problems of large gastrointestinal irritation, poor oral adaptability, drug residues, etc., and reduce drug administration The number of times, the slow release rate, the effect of good efficacy

Inactive Publication Date: 2020-06-09
HUAZHONG AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, enrofloxacin is bitter in taste, has poor oral adaptability, and is highly irritating to the gastrointestinal tract. It needs multiple administrations to give full play to its drug effect, which not only causes a greater stress response to the fish body, but also May cause a series of problems such as drug residues

Method used

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  • Enrofloxacin chitosan nanoparticles
  • Enrofloxacin chitosan nanoparticles
  • Enrofloxacin chitosan nanoparticles

Examples

Experimental program
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Embodiment 1

[0024] 1. Weigh 30mg of chitosan, add it to 20mL of 1wt% acetic acid solution, stir and dissolve and swell overnight to obtain chitosan gel;

[0025] 2. Weigh sodium tripolyphosphate and dissolve it in deionized water to obtain a 1.5 mg / mL sodium tripolyphosphate solution;

[0026] 3. Weigh 4 mg of enrofloxacin, add it to chitosan gel, stir well to dissolve it, add 1mol / l NaOH solution to adjust the pH value to 5.0, continue stirring at room temperature, and add sodium tripolyphosphate solution drop by drop , when light blue opalescence occurs in the system, stop adding the sodium tripolyphosphate solution dropwise, the volume of the sodium tripolyphosphate solution added dropwise is 8mL, and continue stirring for 1h to obtain a suspension of enrofloxacin chitosan nanoparticles liquid;

[0027] 4. Add the remaining enrofloxacin-chitosan nanoparticle suspension into a freezing bottle, pre-freeze at -70°C for 2 hours, and then vacuum freeze-dry at -50°C to obtain enrofloxacin-c...

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Abstract

The invention discloses enrofloxacin chitosan nanoparticles which are prepared by using the following methods: 1, adding chitosan into an acetic acid solution, performing stirring dissolution, and performing swelling over night so as to obtain a chitosan gel; 2, dissolving sodium tripolyphosphate into deionized water so as to obtain a sodium tripolyphosphate solution; 3, adding enrofloxacin into the chitosan gel, performing uniform stirring, adding NaOH to adjust the pH value to 5.0, continuing stirring, adding dropwise the sodium tripolyphosphate solution, when light blue opalescence is generated when the sodium tripolyphosphate solution is added dropwise, and continuing stirring for 1 hour so as to obtain an enrofloxacin chitosan nanoparticle mixed suspension; and 4, drying the enrofloxacin chitosan nanoparticle mixed suspension, so as to obtain the enrofloxacin chitosan nanoparticles. The nanoparticles are simple in preparation method, free of adverse smell, good in palatability andvery good in killing function on catfish edwardsiella tarda.

Description

technical field [0001] The invention belongs to the technical field of drugs for preventing and treating fish diseases, and in particular relates to enrofloxacin chitosan nanoparticles. Background technique [0002] Edwardsiella catfish is mainly phagocytized by macrophages, and reaches various tissues of fish through blood circulation to cause acute infection and other diseases. For fish that have been infected with Edwardsiella siluri and have symptoms of the disease, immediate drug treatment is necessary to control mortality. Studies have shown that Edwardsiella catfish is sensitive to a variety of antibiotics, such as aminoglycosides, cephalosporins and quinolones. Among them, enrofloxacin, the third-generation quinolone antibacterial drug dedicated to veterinary medicine, has killing effects on Gram-negative bacteria, positive bacteria, mycoplasma, chlamydia, etc., has small toxic and side effects, and has no cross-resistance with other antibacterial drugs. Medicinal ...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/36A61K47/02A61K31/496A61P31/04
CPCA61K9/5115A61K9/5161A61K31/496A61P31/04
Inventor 刘小玲马洁乐
Owner HUAZHONG AGRI UNIV
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