Broad-spectrum blood perfusion macroporous adsorption resin and preparation method thereof

A technology for blood perfusion and adsorption resin, which is applied in the fields of blood circulation treatment, chemical instruments and methods, suction instruments, etc., can solve the problems of irreversible damage to the environment, high thermal explosion of nitrobenzene, etc., and achieves the promotion of specific adsorption, reliable strength, good quality The effect of biocompatibility

Active Publication Date: 2020-06-16
西安正阳嘉禾化工科技有限公司
View PDF7 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The swelling agent nitrobenzene used in the preparation process is a highly toxic and explosive solvent, which is controlled by the public security department, and nitrobenzene explodes at high temperature, which has irreversible harm to the environment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Broad-spectrum blood perfusion macroporous adsorption resin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Step (1) white ball polymerization step:

[0051] Add 3.3ml of 0.1% methylene blue, 5g of gelatin, 1.25g of carboxymethyl cellulose, and 400ml of tap water into a 1000ml reactor, start stirring and raise the temperature to 40°C until the liquid in the reactor is mixed evenly to form a water phase; Add 181g of styrene, 19g of 63.3% divinylbenzene, 200g of xylene, and 2g of BPO into the beaker and stir evenly at room temperature to form an oil phase, then pour the oil phase from the beaker into the water phase reactor at room temperature, Stand for stratification, then slowly start stirring to adjust the particle size between 0.4 and 0.8mm, raise the temperature at 80°C for 3 hours for 30 minutes, then raise the temperature for 30 minutes to 90°C for 3 hours, then raise the temperature for 30 minutes at 95°C for 6 hours and then drop At room temperature, obtain polystyrene-divinylphenyl white balls, then extract the white balls with 6 times the volume of methylal, boil th...

Embodiment 2

[0060] Step (1) white ball polymerization step:

[0061] Add 3.3ml of 0.1% methylene blue, 5g of gelatin, 1.25g of carboxymethyl cellulose, and 400ml of tap water to a 1000ml reactor, and start stirring to raise the temperature to 40°C until the liquid in the reactor is mixed evenly to form a water phase; Add 181g of styrene, 19g of 63.3% divinylbenzene, 200g of white oil, and 2g of BPO into the beaker, and stir evenly at room temperature to form an oil phase, then pour the oil phase from the beaker into the water phase reactor at room temperature, and Let it stand for stratification, then slowly start stirring to adjust the particle size between 0.4mm~0.8mm, heat up at 80°C for 30 minutes and hold for 3 hours, then raise the temperature to 90°C for 3 hours in 30 minutes, then heat up at 95°C for 6 hours in 30 minutes Lower the room temperature to obtain polystyrene-divinylphenyl white balls. After the white balls are extracted with 6 times the volume of methylal, boil the bal...

Embodiment 3

[0068] Step (1) white ball polymerization step:

[0069]Add 3.3ml of 0.1% methylene blue, 5g of gelatin, 1.25g of carboxymethyl cellulose, and 400ml of tap water into a 1000ml reactor, start stirring and raise the temperature to 40°C until the liquid in the reactor is mixed evenly to form a water phase; Add 181g of styrene, 19g of 63.3% divinylbenzene, 200g of gasoline, and 2g of BPO into the beaker, stir evenly at room temperature to form an oil phase, then pour the oil phase from the beaker into the water phase reactor at room temperature, and let it stand at room temperature Layering, then slowly start stirring to adjust the particle size between 0.4mm~0.8mm, heat up at 80°C for 30 minutes and keep warm for 3 hours, then rise to 90°C for 30 minutes and keep warm for 3 hours, then raise the temperature at 95°C for 6 hours after 30 minutes, then cool down to room temperature , to obtain polystyrene-divinyl phenyl white balls, and then extract the white balls with 6 times the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
pore sizeaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention provides a preparation method of broad-spectrum blood perfusion macroporous adsorption resin. The preparation method comprises the following steps: 1) a poly(styrene-divinylbenzene) polymerization step, 2) a step of preparing chloromethylated beads by a one-pot method, 3) a step of grafting the chloromethylated beads with functional groups, and 4) a post-treatment step. In the chloromethylation stage of poly(styrene-divinylbenzene), a one-pot method is adopted to prepare the chloromethylated beads, the poly(styrene-divinylbenzene) and a catalyst are directly added after methylal,paraformaldehyde and thionyl chloride are reacted for a certain time, and then chloromethylation is carried out to prepare the chloromethylated beads, and therefore the harm caused by directly usinghighly toxic chloromethyl ether in the traditional process is avoided; when the dry chloromethylated beads prepared by the method are used for carrying out Friedel-Crafts reaction secondary crosslinking, no residual chlorine exists in a generated resin product basically, dichloroethane is used as a swelling agent in the cross-linking process, explosive high-toxicity nitrobenzene does not need to be used as a swelling agent, production is safe, and the prepared macroporous adsorption resin is improved in solvent residue, biocompatibility and other properties.

Description

technical field [0001] The invention belongs to the technical field of blood purification, and in particular relates to a broad-spectrum hemoperfusion macroporous adsorption resin and a preparation method thereof, which are suitable for treating diseases such as uremia, drug poisoning, lupus erythematosus, and excessive bilirubin. Background technique [0002] In contemporary society, with the increasing trend of population aging, the number of patients with "three highs" is increasing, and the number of patients with chronic kidney disease and liver disease caused by this is also increasing. Epidemiological studies have found that the number of patients with renal failure, severe liver disease, and drug poisoning is continuously increasing, which has exceeded early estimates. At present, hemodialysis is the main method for such diseases. However, although dialysis has a history of more than 200 years and has become the main method in the field of blood purification, side ef...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30A61M1/36
CPCB01J20/267B01J20/28064B01J20/28066B01J20/28076B01J20/28083B01J20/28085A61M1/3621A61M1/3679
Inventor 郭圆圆张瑞郁蕾
Owner 西安正阳嘉禾化工科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap