Extraction process for improving purity of atropine extracted from atropa belladonna

Abstract

The invention discloses an extraction process for improving purity of atropine extracted from atropa belladonna, and relates to the technical field of medicines. The extraction method comprises the following steps: 1) drying sodium bismuthate dihydrate, adding the dried sodium bismuthate into deionized water, and putting the obtained solution into a muffle furnace for reacting to obtain bismuth tetroxide; 2) adding the bismuth tetroxide into deionized water, performing ultrasonic stirring, adding hydrobromic acid, performing stirring for reacting, washing the product, and performing drying toobtain a degradation catalyst; 3) grinding atropa belladonna into powder, and then carrying out alcohol leaching and percolating to obtain a percolate; and 4) adding the degradation catalyst into thepercolate, performing a photodegradation reaction under visible light, performing centrifuging, collecting the supernatant, and performing concentrating under reduced pressure to obtain an atropa belladonna extract. According to the method, chlorophyll contained in the atropa belladonna percolate is subjected to photodegradation treatment to achieve the purpose of removing chlorophyll, so that efficient removal of chlorophyll in the atropa belladonna extract is realized, and then purity of atropine in the extract is improved.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to an extraction process for improving the purity of atropine in belladonna. Background technique

[0002] Belladonna is a herbaceous plant of the family Solanaceae. It is a perennial herb native to Western Europe. It was later transplanted to North Africa, West Asia, North America and other places, and it was also introduced and cultivated in China. Its native place is the shady and humid area of ​​the mountain, and it grows in groups in the calcareous soil. The active ingredients in belladonna are scopolamine alkaloids, which are mainly used for abdominal pain caused by stomach cramps, duodenal ulcers, ureteral stones, gastritis and vomiting and diarrhea caused by stomach cramps.

[0003] According to "Chinese Pharmacopoeia" (page 397 of the 2010 edition), the preparation method of belladonna extract is: take 1000 grams of belladonna grass powder, use 85% ethanol as ...