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Extraction process for improving purity of atropine extracted from atropa belladonna

An extraction process, atropine technology, applied in the field of medicine, can solve the problems of increased extraction process, cumbersome, low chlorophyll removal efficiency, etc., to achieve the effect of improving purity, efficient removal, and reducing impact

Inactive Publication Date: 2020-06-19
安徽恒达药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Chinese patent CN2016107888802 discloses a preparation method and application of belladonna liquid extract, and discloses the method of water sedimentation and separation to remove impurity chlorophyll in the percolation liquid, but the removal efficiency of chlorophyll in this process is low, requiring more A better effect can be achieved only after a second separation, which increases the tediousness of the extraction process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] An extraction process for improving the purity of atropine in belladonna, the specific extraction process is as follows:

[0016] 1) Dry sodium bismuthate dihydrate at 140°C for 7 hours, then add the dried sodium bismuthate to deionized water according to the mass-volume ratio of 1:20g / ml, ultrasonically treat it at 300W for 30min, and put it at room temperature Stir at 150r / min for 40min, then put it into a muffle furnace, react at 150°C for 4h, wash the obtained product repeatedly with deionized water, dry at 50°C for 15h, and obtain bismuth tetroxide;

[0017] 2) According to the mass volume ratio of 1:25g / ml, add bismuth tetroxide into deionized water, sonicate at 250W for 25min, and stir at room temperature at 200r / min for 30min, then according to the total volume of the reaction system 5%, add an appropriate amount of hydrobromic acid with a concentration of 1mol / L, and stir the reaction at a speed of 50r / min for 3 hours at room temperature. After the reaction is ...

Embodiment 2

[0022] An extraction process for improving the purity of atropine in belladonna, the specific extraction process is as follows:

[0023] 1) Dry sodium bismuthate dihydrate at 150°C for 5 hours, then add the dried sodium bismuthate to deionized water according to the mass volume ratio of 1:23g / ml, ultrasonically treat it at 350W for 25min, and put it at room temperature Stirring at a speed of 200r / min for 35min, then putting it into a muffle furnace, reacting at 170°C for 3.5h, washing the obtained product repeatedly with deionized water, drying at 55°C for 12h, to obtain bismuth tetroxide;

[0024] 2) According to the mass volume ratio of 1:28g / ml, add bismuth tetroxide to deionized water, sonicate at 300W for 20min, and stir at room temperature at 250r / min for 25min, then according to the total volume of the reaction system 6%, add an appropriate amount of hydrobromic acid with a concentration of 1.3mol / L, and stir the reaction at a speed of 65r / min for 2.5h at room temperatu...

Embodiment 3

[0029] An extraction process for improving the purity of atropine in belladonna, the specific extraction process is as follows:

[0030]1) Dry sodium bismuthate dihydrate at 160°C for 4 hours, then add the dried sodium bismuthate to deionized water according to the mass volume ratio of 1:25g / ml, ultrasonically treat it at 400W for 20min, and put it at room temperature Stir at 250r / min for 30min, then put it into a muffle furnace, react at 180°C for 3h, wash the obtained product repeatedly with deionized water, dry at 60°C for 10h, and obtain bismuth tetroxide;

[0031] 2) According to the mass volume ratio of 1:30g / ml, add bismuth tetroxide to deionized water, sonicate at 350W for 15min, and stir at room temperature at 300r / min for 20min, then according to the total volume of the reaction system 8%, add an appropriate amount of hydrobromic acid with a concentration of 1.5mol / L, and stir the reaction at a speed of 80r / min for 2 hours at room temperature. After the reaction is c...

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Abstract

The invention discloses an extraction process for improving purity of atropine extracted from atropa belladonna, and relates to the technical field of medicines. The extraction method comprises the following steps: 1) drying sodium bismuthate dihydrate, adding the dried sodium bismuthate into deionized water, and putting the obtained solution into a muffle furnace for reacting to obtain bismuth tetroxide; 2) adding the bismuth tetroxide into deionized water, performing ultrasonic stirring, adding hydrobromic acid, performing stirring for reacting, washing the product, and performing drying toobtain a degradation catalyst; 3) grinding atropa belladonna into powder, and then carrying out alcohol leaching and percolating to obtain a percolate; and 4) adding the degradation catalyst into thepercolate, performing a photodegradation reaction under visible light, performing centrifuging, collecting the supernatant, and performing concentrating under reduced pressure to obtain an atropa belladonna extract. According to the method, chlorophyll contained in the atropa belladonna percolate is subjected to photodegradation treatment to achieve the purpose of removing chlorophyll, so that efficient removal of chlorophyll in the atropa belladonna extract is realized, and then purity of atropine in the extract is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an extraction process for improving the purity of atropine in belladonna. Background technique [0002] Belladonna is a herbaceous plant of the family Solanaceae. It is a perennial herb native to Western Europe. It was later transplanted to North Africa, West Asia, North America and other places, and it was also introduced and cultivated in China. Its native place is the shady and humid area of ​​the mountain, and it grows in groups in the calcareous soil. The active ingredients in belladonna are scopolamine alkaloids, which are mainly used for abdominal pain caused by stomach cramps, duodenal ulcers, ureteral stones, gastritis and vomiting and diarrhea caused by stomach cramps. [0003] According to "Chinese Pharmacopoeia" (page 397 of the 2010 edition), the preparation method of belladonna extract is: take 1000 grams of belladonna grass powder, use 85% ethanol as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81C01G29/00B01J27/06
CPCA61K36/81C01G29/00B01J27/06A61K2236/331A61K2236/333B01J35/39
Inventor 张涛
Owner 安徽恒达药业有限公司
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