Polylactic acid porous microspheres as well as preparation method and application thereof

A technology of polylactic acid microspheres and porous microspheres, which is applied in the fields of pharmaceutical formulations, medical science, prostheses, etc., can solve the problems of inconvenience to consumers, short action time, etc., to improve the recovery rate, facilitate volatilization, and ensure safety Effect

Inactive Publication Date: 2020-06-19
CHANGZHOU INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. The simple physical filling effect will be degraded and absorbed in the body, the action time is short, and repeated injections are required, which will bring great pain and inconvenience to consumers
[0007] 2. Facial fillers made from animal-derived materials have certain potential hypersensitivity risks, and hypersensitivity testing is required
[0008] 3. Facial fillers made of synthetic non-degradable materials will have long-term complications such as "granuloma", and because the materials are non-degradable, the long-term safety of the product needs to be highly concerned

Method used

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  • Polylactic acid porous microspheres as well as preparation method and application thereof
  • Polylactic acid porous microspheres as well as preparation method and application thereof
  • Polylactic acid porous microspheres as well as preparation method and application thereof

Examples

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preparation example Construction

[0042] A preparation method of polylactic acid porous microspheres, comprising the following steps:

[0043] Step S10, dissolving polylactic acid in methylene chloride to form a polylactic acid solution, and then adding polyethylene glycol as a porogen and mixing evenly to obtain an oil phase solution;

[0044] Specifically, in order to make polylactic acid dissolve better, polylactic acid is dissolved in methylene chloride through a vortex mixer, and the concentration of polylactic acid in methylene chloride is 10% to 30%; the amount of polyethylene glycol and The dosage ratio of the polylactic acid is 0.1:1-3:1, and the molecular weight of the polylactic acid is 3W-10W.

[0045] Step S20, pour the polyvinyl alcohol raw material into a beaker, add deionized water, and stir at 97°C using a magnetic stirring water bath until the polyvinyl alcohol is completely dissolved, and the solution is colorless and transparent, and the concentration is prepared to be 4.0%~ 6.0% polyvinyl...

Embodiment 1

[0069] Dissolve racemic polylactic acid (PDLLA) with a molecular weight of 50,000 in dichloromethane to prepare a polylactic acid solution with a concentration of 15 wt%, and then add polyethylene glycol (PEG- 400) as a porogen, and then the polylactic acid solution was mixed with the prepared 4.8wt% polyvinyl alcohol aqueous solution (the volume ratio of the polylactic acid solution to the polyvinyl alcohol solution was 1:25), at 20 °C The emulsification stirring was carried out under the following conditions, the stirring rate was 500 r / min, and the stirring time was 40 min to obtain an O / W emulsion. Then the emulsion water bath was heated to 40 °C, and after stirring at a low speed (60 rpm) for 12 h, the dichloromethane was basically completely volatilized, and the emulsion solidified into microspheres and precipitated. After the solidification of the microspheres is completed, the polylactic acid microsphere suspension is wet-screened through a sieve with a specific mesh n...

Embodiment 2

[0071] Dissolve racemic polylactic acid (PDLLA) with a molecular weight of 80,000 in dichloromethane to prepare a polylactic acid solution with a concentration of 25 wt%, and then add polyethylene glycol (PEG- 400) as a porogen, and then mixed the polylactic acid solution with the prepared 5.0wt% polyvinyl alcohol aqueous solution (the volume ratio of the polylactic acid solution to the polyvinyl alcohol solution was 1:40), at 20 °C The emulsification and stirring were carried out at a temperature of 400 r / min and the stirring time was 30 min to obtain an O / W emulsion. Then the emulsion water bath was heated to 40 °C, and after stirring at a low speed (60 rpm) for 16 h, the dichloromethane was basically completely volatilized, and the emulsion solidified into microspheres and precipitated. After the solidification of the microspheres is completed, the polylactic acid microsphere suspension is wet-screened through a sieve with a specific mesh number, and the microspheres with a...

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Abstract

The invention relates to a preparation method of polylactic acid porous microspheres. The method comprises the following steps: respectively preparing an oil phase solution and a water phase solution;pouring the oil phase solution into the water phase solution, and performing uniform stirring to obtain an O/W emulsion; stirring the O/W emulsion to obtain a polylactic acid microsphere suspension,screening out microspheres with a target particle size from the polylactic acid microsphere suspension, and performing collection to obtain semi-finished polylactic acid microspheres; and performing freeze-drying on the semi-finished polylactic acid microspheres to obtain the finished polylactic acid microspheres. The invention provides the polylactic acid porous microspheres, and the polylactic acid porous microspheres are prepared by using the above method. The invention also provides an application of the polylactic acid porous microspheres as a facial filler. The polylactic acid porous microspheres can produce encapsulation and fibrosis through a chronic inflammatory tissue reaction to stimulate human collagen proliferation to achieve the effect of filling beauty, and the porous structure characteristic can effectively reduce the residual of organic reagents, thereby ensuring the safety of the product.

Description

technical field [0001] The invention relates to a polylactic acid porous microsphere, its preparation method and application. Background technique [0002] Polylactic acid material is a biomedical material approved by the US Food and Drug Administration (FDA). It has excellent biocompatibility and biodegradability. In the field of biomedical polymer materials, it is widely used to prepare surgical sutures. , microspheres, bone nails and 3D scaffolds and other forms of medical devices. Among them, polylactic acid microspheres have attracted much attention in the pharmaceutical and medical aesthetic industries because of their rounded structure and unique physiological effects. [0003] Polylactic acid microspheres have also become "children's face needles" in the beauty industry. It is a microspherical particle powder prepared by polylactic acid materials through emulsification volatilization, spray drying, and membrane emulsification methods. When polylactic acid microspher...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/50A61L27/56A61L27/58
CPCA61L27/18A61L27/20A61L27/56A61L27/50A61L27/58A61L2400/06C08L67/04C08L1/286
Inventor 张谦管汉亮耿文鑫李立文
Owner CHANGZHOU INST OF MATERIA MEDICA
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