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Preparation method of double-mesoporous silica fluorescent hybrid material

A technology of silica and hybrid materials, which is applied in the field of fluorescent hybrid materials, can solve the problems of low drug loading, small specific surface area, unfavorable practical application, etc., and achieve the effect of simple process, good luminescence performance and good water solubility

Pending Publication Date: 2020-06-30
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the small specific surface area leads to low drug loading, which is not conducive to practical application.

Method used

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  • Preparation method of double-mesoporous silica fluorescent hybrid material
  • Preparation method of double-mesoporous silica fluorescent hybrid material
  • Preparation method of double-mesoporous silica fluorescent hybrid material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: double mesoporous fluorescent hybrid material (CQDs / SiO 2 ) preparation

[0023] The preparation method of CQDs is as follows: 10 mg of glucose was dissolved in 50 mL of deionized water, placed in a 100 mL stainless steel autoclave containing a polytetrafluoroethylene liner, and kept at 150 ° C for 20 h; after cooling to room temperature, the obtained solution was qualitatively filter paper, and the solution obtained after filtration is the CQDs aqueous solution.

[0024] CQDs / SiO 2 The synthesis of CQDs is as follows: 12.56g CTAB was added to 500mL of CQDs aqueous solution prepared in the above steps, kept at 40°C, and magnetically stirred until completely dissolved, then 36.05g of TEOS was added dropwise, and then 11.54mL of ammonia water (mass percentage concentration of 25%), continued to stir for 8min, and the solution gradually formed a brown gel. After the gel was filtered and washed with water, it was placed in a constant temperature drying oven...

Embodiment 2

[0028] Example 2: Preparation of dual mesoporous fluorescent hybrid materials

[0029] The preparation method of CQDs is as follows: 10 mg of glucose was dissolved in 50 mL of deionized water, placed in a 100 mL stainless steel autoclave containing a polytetrafluoroethylene liner, and kept at 150 ° C for 20 h; after cooling to room temperature, the obtained solution was qualitatively filter paper, and the solution obtained after filtration is the CQDs aqueous solution.

[0030] CQDs / SiO 2 The synthesis of CQDs is as follows: 12.56g CTAB was added to 500mL of CQDs aqueous solution prepared in the above steps, kept at 50°C, and magnetically stirred until completely dissolved, then 36g of TEOS was added dropwise, and then 11.54mL of ammonia water (mass percentage concentration of 25 %), continued to stir for 8min, and the solution gradually formed a brown gel. After the gel was filtered and washed with water, it was placed in a constant temperature drying oven at 80° C. for 30 ...

Embodiment 3

[0032] Example 3: Preparation of dual mesoporous fluorescent hybrid materials

[0033] The preparation method of CQDs is as follows: 15 mg of glucose was dissolved in 50 mL of deionized water, placed in a 100 mL stainless steel autoclave containing a polytetrafluoroethylene liner, and kept at 140 ° C for 16 h; after cooling to room temperature, the obtained solution was qualitatively filter paper, and the solution obtained after filtration is the CQDs aqueous solution.

[0034] CQDs / SiO 2 The synthesis of CQDs is as follows: 10g CTAB was added to 500mL of CQDs aqueous solution prepared in the above steps, kept at 60°C, and magnetically stirred until completely dissolved, then 30g of TEOS was added dropwise, and then 10mL of ammonia water (mass percentage concentration was 25%) , and continued to stir for 9min, the solution gradually formed a brown gel. After the gel was filtered and washed with water, it was placed in a constant temperature drying oven at 100° C. for 15 hour...

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Abstract

The invention discloses a preparation method of a double-mesoporous silica fluorescent hybrid material, and belongs to the technical field of preparation of fluorescent hybrid materials. The method comprises the following steps: firstly, obtaining a carbon quantum dot aqueous solution through glucose hydrothermal reaction; dissolving a surfactant hexadecyl trimethyl ammonium bromide into the carbon quantum dot aqueous solution, adding tetraethoxysilane and ammonia water, and obtaining an intermediate through a sol-gel method; and finally, removing the surfactant in the intermediate by using asolvent method so as to prepare the double-mesoporous fluorescent hybrid material. The fluorescent hybrid material prepared by the invention has a relatively large specific surface area (700-1200m < 2> / g) and a double-mesoporous structure (2.7-3.1 nm and 22-29nm), is stable in luminescence, and can be used as a drug sustained-release carrier; the preparation process is simple to operate and has industrial practicability.

Description

technical field [0001] The invention belongs to the field of fluorescent hybrid materials, in particular to a method for preparing a double mesoporous silicon dioxide fluorescent hybrid material. Background technique [0002] So far, researchers have conducted extensive studies on how to adjust the mesoporous structure and surface properties for better application in the field of sustained drug release. In particular, the introduction of organic fluorescent molecules on the surface of mesoporous silica is conducive to exploring drug loading behavior and release kinetics by tracking fluorescent signals. For example, Lee et al. (J.E.Lee, J.AM.CHEM.SOC.2010, 132:552-557) prepared SiO with uniform particle size 2 Nanoparticles doped with dyes were used to detect sustained-release properties of doxorubicin (DOX) in mouse tumor tissues by optical imaging. Although organic fluorescent molecules have the advantages of low toxicity and good biocompatibility in the field of drug-loa...

Claims

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Application Information

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IPC IPC(8): C01B33/16C01B32/15C09K11/65B82Y40/00B82Y30/00B82Y20/00
CPCC01B33/163C01B32/15C09K11/65B82Y40/00B82Y30/00B82Y20/00C01P2002/72C01P2004/03C01P2004/04C01P2006/17C01P2006/60C01P2006/16C01P2006/12
Inventor 孙继红李俊芳徐小欢白诗杨
Owner BEIJING UNIV OF TECH
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