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Collagen dressing capable of realizing sustained and control release of antibiotics and preparation method of collagen dressing

A technology of antibiotics and collagen, applied in medical science, absorbent pads, bandages, etc., can solve the problems of materials that cannot be applied to infection, fast degradation speed, low mechanical strength, etc., to improve liquid absorption, adhesion, and anti-degradation performance Low, low mechanical strength effect

Inactive Publication Date: 2020-07-10
无锡贝迪生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Collagen dressings currently used clinically have disadvantages such as poor liquid absorption, low mechanical strength, and fast degradation speed. It is often necessary to improve the mechanical strength and degradation resistance of the material through chemical cross-linking, which cannot avoid the damage caused by the residue of chemical cross-linking agents. Risk of cytotoxicity. For example, patent applications with publication numbers CN108721690A and CN108744014A respectively provide a drug slow-release antibacterial dressing, but they all use chemical cross-linking, there is a risk of cytotoxicity, and they need to be freeze-dried twice , the cost is relatively high
In addition, there are very few collagen dressings with compound antibiotics in China at present, and the materials cannot be applied to infected wounds, and can only be used after thorough debridement

Method used

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  • Collagen dressing capable of realizing sustained and control release of antibiotics and preparation method of collagen dressing
  • Collagen dressing capable of realizing sustained and control release of antibiotics and preparation method of collagen dressing
  • Collagen dressing capable of realizing sustained and control release of antibiotics and preparation method of collagen dressing

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Effect test

Embodiment 1

[0055] A preparation method of a collagen dressing capable of slow and controlled release of antibiotics, the steps of the method are as follows:

[0056] Preparation of insoluble collagen fibers: slice the tendon, wash, pulverize, degrease and sterilize. Weigh 100 g of pretreated beef tendon slices, put them into 500 mL of 1% NaOH aqueous solution, mix them evenly, and soak them at 8°C for 5 days. After soaking, wash with 0.1% acetic acid aqueous solution until white flocs are precipitated. Put the white floc into 500mL of 4% hydrochloric acid solution, and slowly stir for 20h at 10°C. After acid treatment, wash with purified water until the weight of the floc is 2.5 times that of the beef tendon sheet, and finally the floc is crushed into uniform white silky short fibers with a pulverizer, and the dry matter content is measured to obtain its The dry matter content was 12.86%.

[0057] The preparation of the collagen dressing that can release antibiotic slowly: Weigh 62.21...

Embodiment 2

[0059] A preparation method of a collagen dressing capable of slow and controlled release of antibiotics, the steps of the method are as follows:

[0060] Preparation of insoluble collagen fibers: slice the tendon, wash, pulverize, degrease and sterilize. Weigh 100 g of pretreated beef tendon slices, put them into 500 mL of 1.5% NaOH aqueous solution, mix them evenly, and soak them at 9° C. for 6 days. After soaking, wash with 0.12% acetic acid aqueous solution until white flocs are precipitated. Put the white floc into 500mL 5% hydrochloric acid solution, and stir slowly for 19h at 10°C. After the acid treatment, wash with purified water until the weight of the flocs is twice that of the beef tendon slices. Finally, the flocs are crushed into uniform white filamentous short fibers with a pulverizer, and the dry matter content is measured. The dry matter content was 10.85%.

[0061] The preparation of the collagen dressing that can release antibiotic slowly: Weigh 41.47g in...

Embodiment 3

[0063] A preparation method of a collagen dressing capable of slow and controlled release of antibiotics, the steps of the method are as follows:

[0064] Preparation of insoluble collagen fibers: slice the tendon, wash, pulverize, degrease and sterilize. Weigh 100 g of pretreated beef tendon slices, put them into 500 mL of 2% NaOH aqueous solution, mix well, and soak for 5 days at 10° C. After soaking, wash with 0.15% acetic acid aqueous solution until white flocs are precipitated. Put the white floc into 500mL of 4% hydrochloric acid solution, and slowly stir for 20h at 10°C. After the acid treatment, wash with purified water until the weight of the floc is 3 times that of the beef tendon slices, and finally the floc is crushed into uniform white silky short fibers with a pulverizer, and its dry matter content is measured. The dry matter content was 13.12%.

[0065] The preparation of the collagen dressing that can release antibiotic slowly: Weigh 102.90g insoluble collag...

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Abstract

The present invention provides a collagen dressing capable of realizing sustained and control release of antibiotics and a preparation method of the collagen dressing, and belongs to the technical field of medical biological materials. The method comprises the following steps of preparing soluble collagen, preparing insoluble collagen fibers, preparing collagen mixed liquid, and preparing the collagen-antibiotic composite dressing. The collagen dressing provided by the present invention has the advantages that (1) the collagen dressing has the high mechanical strength and anti-degradation performance, and can temporarily replace the damaged tissues to take a certain supporting effect; (2) the collagen dressing can quickly absorb wound exudate heavier than the collagen dressing by about 40times, clings to a wound bed, and provides a good wet environment for wound healing; (3) the collagen dressing can realize sustained and control release of the antibiotics to take the continuous antibacterial and antiphlogistic effects; and (4) dressings in different shapes can be prepared by selection of different freeze-drying molds and used for various departments such as the general surgery department, the orthopedics department and the stomatology department.

Description

technical field [0001] The invention relates to a collagen dressing capable of slow and controlled release of antibiotics and a preparation method thereof, belonging to the technical field of medical biomaterials. Background technique [0002] Collagen dressing is a relatively new dressing in the wound treatment market. As the main component of extracellular matrix, collagen has excellent properties such as biocompatibility, degradability, cell growth promotion, and controllable cross-linking degree. It has shown great advantages in the fields of burn trauma and tissue repair, and has great application value. A large number of experiments and clinical studies at home and abroad have shown that collagen has a strong role in promoting skin wound repair. [0003] The open pore structure of collagen dressings can quickly absorb wound exudate, combine proteases and cytokines that inhibit wound healing, protect growth factors that promote wound healing, stimulate fibroblast migra...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/42A61L15/44A61L15/46A61L15/62
CPCA61L15/325A61L15/42A61L15/425A61L15/44A61L15/46A61L15/62A61L2300/406
Inventor 陆金婷石丽虹程咏梅王立军任伟业
Owner 无锡贝迪生物工程股份有限公司
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