Tetravalent influenza virus subunit vaccine and preparation method thereof

A subunit vaccine and influenza virus technology, applied in the field of quadrivalent influenza virus subunit vaccine and its preparation, can solve problems such as the loss of active ingredients, shorten the storage period of vaccines, and reduce the level of antibodies, so as to prolong the storage period, reduce the content, Effects of Elevated Antibody Levels
CN111420044AActive Publication Date: 2020-07-17ZHONGYI ANKE BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHONGYI ANKE BIOTECH CO LTD
Publication Date
2020-07-17

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Abstract

The invention belongs to the technical field of biology, and particularly relates to a tetravalent influenza virus subunit vaccine and a preparation method thereof. Each dose of the tetravalent influenza virus subunit vaccine contains H1N1, H3N2 and two types of B; and the tetravalent influenza virus subunit vaccine is prepared by virus inoculation, virus multiplication culture, allantoic fluid harvesting, clarification, inactivation, ultrafiltration concentration, cracking and ultracentrifugal purification, mixing, filtration sterilization, split charging and packaging, wherein the inactivation process comprises the following steps: firstly, adding a carboxymethyl glucan solution into monovalent virus harvesting liquid, and then adding formaldehyde for inactivation. According to the method disclosed by the invention, the content of free formaldehyde in the prepared tetravalent influenza virus subunit vaccine is reduced, the storage life of the vaccine is prolonged, and the antibody level after vaccine immunization is increased.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, in particular to a quadrivalent influenza virus subunit vaccine and a preparation method thereof. Background technique

[0002] Influenza is caused by influenza virus, which can cause large-scale epidemics of acute respiratory diseases transmitted by humans and animals. Influenza viruses are divided into three types: A, B, and C. Among them, type A has the strongest pathogenicity and can infect animals and humans and cause epidemics or even worldwide pandemics; type B is slightly less pathogenic and can cause local epidemics. Influenza viruses often undergo antigenic drift and antigenic shift to evade the defenses of the body's immune system, which is also the cause of the pandemic. Influenza viruses are highly contagious and spread through the air through droplets. After a short incubation period, high fever and chills develop rapidly, and the body temperature can reach as high as 40°C within 1-2...

Claims

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