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Hydrogel dressing capable of effectively accelerating repair and regeneration of wound surface, and preparation method and application of hydrogel dressing

A wound repair and hydrogel technology, applied in medical science, bandages, etc., can solve the problems of rare chronic wound ulcers, difficult wound healing, weak healing ability, etc., to improve pain and itching, and promote repair and regeneration Good, reduce itching effect

Active Publication Date: 2020-07-28
首都医科大学附属北京潞河医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned composite material repairs the blood-spinal cord barrier after SCI by solution injection, but it is rarely used in the preparation of chronic wound ulcers caused by diabetes, vascular disease, infection, etc. based on the above-mentioned research in the prior art. Wound healing, dressings for acute wound healing or wound healing after severe impact
At present, most of the materials that promote wound healing are dressings, but due to chronic wound ulcers caused by diabetes, vascular diseases, infections, etc., it is difficult to heal acute wounds or wounds after severe collisions, and their own healing ability is relatively weak. Pain and itching during the wound healing phase

Method used

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  • Hydrogel dressing capable of effectively accelerating repair and regeneration of wound surface, and preparation method and application of hydrogel dressing
  • Hydrogel dressing capable of effectively accelerating repair and regeneration of wound surface, and preparation method and application of hydrogel dressing
  • Hydrogel dressing capable of effectively accelerating repair and regeneration of wound surface, and preparation method and application of hydrogel dressing

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0051] Preparation of the blank hydrogel: prepare the blank hydrogel by the inverted bottle method, take 330 mg of four-arm acrylate polyethylene glycol and 10 mg of DL-dithiothreitol, add to 6.8 mL of PBS with a pH of 7.4 In the buffer solution, stir evenly, and pour it into a vial after 20 min. If there is no liquid flow phenomenon, a blank hydrogel is prepared, and the time of this process is recorded as the gelation time. The reaction equation of the blank hydrogel and the state diagrams before and after gelation during the preparation of the blank hydrogel are shown in figure 1 In (A), (B) shown.

preparation example 2

[0053] Preparation of heparin-hydrogel dressing:

[0054] Take 330 mg of four-arm acrylate polyethylene glycol and 10 mg of DL-dithiothreitol, add it to 6.8 mL of PBS buffer solution with a pH of 7.4, and stir evenly to obtain a hydrogel solution;

[0055] 1 mg / mL heparin was added to the above hydrogel solution, stirred evenly, and after standing for 20 min, there was no liquid flow phenomenon, and a heparin-hydrogel dressing was prepared.

Embodiment 1

[0062] A method for preparing a hydrogel dressing that effectively promotes wound repair and regeneration, comprising the following steps:

[0063] Preparation of S1 hydrogel solution: Take 330 mg of four-arm acrylate polyethylene glycol and 10 mg of DL-dithiothreitol, add it to 6.8 mL of PBS buffer solution with a pH of 7.4, and stir at room temperature Uniform, that is, to obtain the pre-hydrogel solution;

[0064] S2 Add 1 mg / mL heparin and 500 ng / mL bFGF to the hydrogel solution in step S1, stir evenly, after a period of time, there is no liquid flow, and the hydrogel-bFGF dressing is prepared.

[0065] Preparation result:

[0066] The Michael addition reaction (Michael) occurred between the four-arm acrylate polyethylene glycol and DL-dithiothreitol, and the gelation was carried out in PBS buffer at pH 7.4, and the gelation was successful after 20 min, while The gelation time of 20 min provides enough operation time for the addition of heparin and bFGF of the present in...

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Abstract

The invention discloses a hydrogel dressing capable of effectively accelerating the repair and the regeneration of a wound surface, and a preparation method and application of the hydrogel dressing. The preparation method for the hydrogel dressing comprises the following steps of: S1: carrying out raw material preparation: adding a multi-sulfydryl compound and multi-arm polyethylene glycol of which the end group is a double bond into PBS (Phosphate Buffer Saline), and evenly stirring to obtain a hydrogel preliminary liquid; and S2: adding heparin and a bFGF (basic fibroblast growth factor) into the hydrogel solution, stirring, standing until no liquid flows, and preparing the heparin-bFGF hydrogel dressing. The prepared heparin-bFGF hydrogel dressing guarantees that the heparin and the bFGF are stably slowly released within time longer than 10 days, and the heparin-bFGF hydrogel dressing is applied to wound surface healing of chronic wound surface ulcers caused by diabetes mellitus, vascular diseases, infection and the like. The heparin-bFGF hydrogel dressing disclosed by the invention has the advantages that the exogenous bFGF is effectively slowly released on a wound surface andthe wound surface healing of the chronic wound surface ulcers is accelerated.

Description

technical field [0001] The invention relates to the technical field of wound repair, more specifically, it relates to a hydrogel dressing that effectively promotes wound repair and regeneration, its preparation method and application. Background technique [0002] In daily life, timely healing is very necessary for skin tissue damage or damage caused by various external factors and large or small wounds caused by chronic diseases, otherwise small wounds will cause serious ulcers, or even due to External bacterial infection with life-threatening consequences. Currently, medical dressings are commonly used as a wound-healing material that can help control bleeding, prevent infection, and absorb secretions. With the development of medicine, the theory of wet wound healing has been widely studied and recognized: the main purpose of using wet medical dressings is to create a moist environment on the wound surface, and to enhance the growth of macrophages and fibroblasts in a moi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/008A61L26/0066A61L26/0061A61L2300/236A61L2300/406A61L2300/414A61L2300/602C08L71/02
Inventor 赵辉叶霖
Owner 首都医科大学附属北京潞河医院
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