A kind of nano calcium carbonate Pickering emulsion loaded with vitamin D3 and its preparation method and application
A technology of nano-calcium carbonate and Pickering emulsion, which is applied in the fields of food and medicine, can solve problems such as discounting the emulsification performance of nano-calcium carbonate, limiting the application of modified nano-calcium carbonate, and the toxicity of chemical modifiers, so as to improve bioavailability, Reduces the burden on the gastrointestinal tract and has good stability
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Embodiment 1
[0063] 1. Ingredients
[0064] Nano-calcium carbonate suspension: take food-grade nano-calcium carbonate powder, add water to make a nano-calcium carbonate suspension with a concentration of 50 mg / mL, and set aside;
[0065] 2. High static pressure dispersion
[0066] The nano-calcium carbonate suspension in step 1 is placed in a high static pressure device, and the working pressure is maintained for 20 min under the condition of 300 MPa to obtain a nano-calcium carbonate dispersion;
[0067] 3. Vitamin D3 oil solution
[0068] Vitamin D3 oil solution: take food-grade vitamin D3, add it to medium-chain fatty acid solution, stir for 1 hour at room temperature, away from light, at a stirring speed of 200rpm, to completely dissolve vitamin D3, and prepare a 100 IU / mL vitamin D3 oil solution for later use ;
[0069] 4. Preparation of Pickering emulsion
[0070] Mix the nano-calcium carbonate dispersion obtained in step 2 with the vitamin D3 oil solution obtained in step 3 at a...
Embodiment 2
[0087] 1. Ingredients
[0088] Nano-calcium carbonate suspension: take food-grade nano-calcium carbonate powder, add water to make a nano-calcium carbonate suspension with a concentration of 40 mg / mL, and set aside;
[0089] 2. High static pressure dispersion
[0090] With the nano-calcium carbonate suspension in step 1 in the high static pressure equipment, it is kept 30 min under the condition of 250 MPa at working pressure, obtains the nano-calcium carbonate dispersion;
[0091] 3. Vitamin D3 oil solution
[0092] Vitamin D3 oil solution: take food-grade vitamin D3, add it to corn oil, stir at room temperature for 2 h in the dark, at a stirring speed of 300 rpm, to completely dissolve vitamin D3, and prepare a 200 IU / mL vitamin D3 oil solution for later use;
[0093] 4. Preparation of Pickering emulsion
[0094] Mix the nano-calcium carbonate dispersion obtained in step 2 with the vitamin D3 oil solution obtained in step 3 at a volume ratio of 2:8, high-speed shear homog...
Embodiment 3
[0100] 1. Ingredients
[0101] Nano-calcium carbonate suspension: take food-grade nano-calcium carbonate powder, add water to make a nano-calcium carbonate suspension with a concentration of 20 mg / mL, and set aside;
[0102] 2. High static pressure dispersion
[0103] The nano-calcium carbonate suspension in step 1 is kept in a high static pressure device for 30 min at a working pressure of 400 MPa;
[0104] 3. Vitamin D3 oil solution
[0105] Vitamin D3 oil solution: Take food-grade vitamin D3, add it to soybean oil, stir for 3 hours at room temperature, away from light, at a stirring speed of 400rpm, to completely dissolve vitamin D3, and prepare a 50 IU / mL vitamin D3 oil solution for later use;
[0106] 4. Preparation of Pickering emulsion
[0107] Mix the nano-calcium carbonate dispersion obtained in step 2 with the vitamin D3 oil solution obtained in step 3 at a volume ratio of 3:7, and homogenize at high speed for 14 min at a shear rate of 10,000 rpm to obtain nano-ca...
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