Preparation method of bioactive porous tantalum implant

A bioactive, porous tantalum technology, used in tissue regeneration, prostheses, coatings, etc., can solve the problems of suboptimal surface bioactive modification, no promotion of new bone formation, and inability to achieve modification, etc. Osteoinduction and bone ingrowth, improved distribution uniformity and stability, reasonable proportions

Active Publication Date: 2020-08-04
天衍医疗器材有限公司
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  • Abstract
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Problems solved by technology

[0003] However, the bioactive modification of the surface of porous tantalum materials in the prior art is not ideal
The currently prepared porous tantalum is different from the composition of bone, and cannot chemically combine with bone formation in the early stage of implantation, nor has the ability to promote new bone formation
The surface biofunctional modification of three-dimensional porous tantalum has the following problems: (1) It is difficult to uniformly spray the surface and interior of the traditional linear spraying method; (2) Due to the three-dimensional porous structure, the resistance and other properties of the porous metal material are changed , electrochemical modification methods, such as anodic oxidation and micro-arc oxidation, according to the traditional electrical parameters and chemical composition of the electrolyte, can no longer play a role in its modification

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  • Preparation method of bioactive porous tantalum implant
  • Preparation method of bioactive porous tantalum implant
  • Preparation method of bioactive porous tantalum implant

Examples

Experimental program
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Effect test

Embodiment 1

[0048] Preparation steps of bioactive functional porous tantalum implant:

[0049] The three-dimensional porous tantalum implant material prepared by vapor deposition method is used as the modification object of Example 1. The three-dimensional porous tantalum implant material is an intervertebral fusion device with a height of 8 mm. The intervertebral fusion device has a porous structure. The intervertebral fusion The device has a central hole, the diameter of the inscribed circle of the central hole is 8mm, the diameter of the circumscribed circle is 20mm, and the angle between the upper and lower end surfaces is 8°. Carry out pickling treatment on the intervertebral fusion cage, the pickling solution used includes hydrofluoric acid, nitric acid and water; the concentration of hydrofluoric acid is 40%, the concentration of nitric acid is 68%, the volume ratio of hydrofluoric acid, nitric acid and water It is 5:8:87; pickling time is 3 minutes. The pickled intervertebral cag...

Embodiment 2

[0051] Preparation steps of bioactive functional porous tantalum implant:

[0052] The three-dimensional porous tantalum implant material prepared by powder metallurgy is used as the modified object of Example 2. The three-dimensional porous tantalum implant material is an artificial vertebral body with a height of 50 mm. The artificial vertebral body is a porous structure. The artificial vertebral body has a The central hole, the diameter of the inscribed circle of the central hole is 6mm, the diameter of the circumscribed circle is 20mm, and the angle between the upper and lower end faces is 8°. Carry out pickling treatment to artificial vertebral body, the pickling solution that adopts comprises hydrofluoric acid, nitric acid and water; The concentration of hydrofluoric acid is 40%, the concentration of nitric acid is 68%, the volume ratio of hydrofluoric acid, nitric acid, water is 2:8:90; pickling time is 2 minutes. The artificial vertebral body after pickling was ultras...

Embodiment 3

[0054] Preparation steps of bioactive functional porous tantalum implant:

[0055] The three-dimensional porous tantalum implant material prepared by electron beam melting technology is used as the modification object of embodiment 3. The three-dimensional porous tantalum implant material is an acetabular cup, and the surface structure of the acetabular cup is a porous structure, and the spherical outer diameter of the acetabular cup is 50mm, the acetabular height is 36mm. The acetabular cup is pickled, and the pickling solution used includes hydrofluoric acid, nitric acid and water; the concentration of hydrofluoric acid is 40%, the concentration of nitric acid is 68%, and the volume ratio of hydrofluoric acid, nitric acid and water is 5:10:85; pickling time is 5 minutes. The acid-washed acetabular cup was ultrasonically cleaned with acetone and deionized water for 30 minutes in sequence. After ultrasonic cleaning, the acetabular cup was subjected to micro-arc oxidation trea...

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Abstract

The invention discloses a preparation method of a bioactive porous tantalum implant, which comprises the following steps: carrying out acid pickling treatment on a three-dimensional porous tantalum implant material to obtain a pretreated material; performing micro-arc oxidation treatment on the pretreated material, an in-situ growth film layer with bioactive substances is formed on the surface ofthe pretreated material, and an electrolyte adopted in the micro-arc oxidation treatment comprises bioactive functional substances; and carrying out hydrothermal treatment on the in-situ growth film layer to obtain the bioactive porous tantalum implant. Tests prove that the in-situ growth film layer can effectively endow the three-dimensional porous tantalum implant material with a biological activity function. The prepared porous tantalum implant with the living activity is simple in technological process, easy to realize industrial production, simple in electrolyte and hydrothermal treatmentsolution components, free of pollutants, easy to control and low in cost, can be used for preparing various orthopaedic implant materials, and has a wide application prospect.

Description

technical field [0001] The invention relates to the field of preparation of medical materials, in particular to a method for preparing bioactive porous tantalum implants. Background technique [0002] At present, the processing methods of porous tantalum mainly include vapor deposition method, foam impregnation method and additive manufacturing process, etc. The porous tantalum obtained by different processes has different shapes, but they all have good porous structure; porous tantalum has no cytotoxicity, porosity High, uniform pore distribution and other characteristics, the existing technology has been able to achieve, such as a medical porous tantalum metal material (patent publication number: CN105177523A), the porous tantalum metal material disclosed by it has a high porosity, and is an interconnected porous structure , with less porosity and dead space, similar to human cancellous bone, can promote bone ingrowth, and can be applied to the repair of bone defects after...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/56A61L27/54A61L27/32C25D11/26
CPCA61L27/047A61L27/56A61L27/54A61L27/32C25D11/26C25D11/026C25D11/024A61L2430/02A61L2300/112A61L2300/412A61L2300/606
Inventor 魏崇斌李新宇
Owner 天衍医疗器材有限公司
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