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Preparation and application of manganese oxide nano-cluster

A technology of nano-clusters and manganese oxide, which is applied in the field of nano-biomedicine, can solve the problems of difficult metabolism of particles, low relaxation rate, and uneven particle size, and achieve good monodispersity and stability, broad application prospects, and particle size uniform effect

Active Publication Date: 2020-08-04
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The particle size of the former is not uniform and the particles are large, which is suitable for industrial fields such as catalysis or battery applications; the latter often has high requirements on equipment and devices due to high temperature reaction in the preparation, and the single batch yield is low, making it difficult to Conducive to the large-scale application of manganese oxide nanomaterials
The currently prepared manganese oxide nanomaterials have low yield, poor stability, r 1 The relaxation rate is low, and its main manifestations are: low yield, not easy to use in large animal models, uneven particle size distribution, poor dispersion, small specific surface area, weak colloidal stability, etc., and large particles are not easy to metabolize, especially in the blood Problems such as agglomeration often occur in biological systems such as cell culture fluid and cell culture fluid, which bring many troubles to subsequent diagnosis and precise treatment. The main reason is that the preparation and modification of manganese oxide nanoparticles are not satisfactory.

Method used

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  • Preparation and application of manganese oxide nano-cluster
  • Preparation and application of manganese oxide nano-cluster
  • Preparation and application of manganese oxide nano-cluster

Examples

Experimental program
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Effect test

Embodiment 1

[0039] A kind of preparation of manganese oxide nanocluster specifically comprises the following steps:

[0040] (1) under nitrogen protection, the diphenyl ether of 1g manganese chloride, 5g oleic acid and 20ml is mixed in the three-neck round bottom flask of 100ml, obtains solution a;

[0041] (2) After the solution a was vacuum-exhausted, it was heated to 200°C at a heating rate of 5°C / min under the protection of nitrogen, and continued to heat at this temperature for 1 hour until the reaction was terminated and dropped to room temperature, and the obtained brown liquid was solution b;

[0042](3) Place solution b in a centrifuge tube, centrifuge to precipitate after adding 30ml of absolute ethanol (centrifugal conditions: 5000rpm, 10min) and resuspend the precipitate in chloroform, repeat the cleaning method twice, and the final product is dispersed Solution c in chloroform;

[0043] (4) Mix 10ml of solution c with a concentration of 1g / ml and 20ml of a polyethylene glyco...

Embodiment 2

[0049] A kind of preparation of manganese oxide nanocluster specifically comprises the following steps:

[0050] (1) Under nitrogen protection, 1.2g of potassium permanganate, 5g of oleylamine and 20ml of dibenzyl ether were mixed in a 100ml three-neck round bottom flask to obtain solution a;

[0051] (2) After the solution a is vacuum-exhausted, it is heated to 250°C at a heating rate of 1°C / min under the protection of nitrogen, and is continuously heated at this temperature for 2 hours until the reaction is terminated and dropped to room temperature, and the obtained brown liquid is solution b;

[0052] (3) Place solution b in a centrifuge tube, centrifuge to precipitate after adding 25ml of absolute ethanol (centrifugal condition: 3000rpm, 15min) and resuspend the precipitate in chloroform, repeat the cleaning method twice, and the final product is dispersed Solution c in chloroform;

[0053] (4) Mix 10ml of solution c with a concentration of 1g / ml and 30ml of a polyethyle...

Embodiment 3

[0057] A kind of preparation of manganese oxide nanocluster specifically comprises the following steps:

[0058] (1) Under nitrogen protection, 2g of manganese acetylacetonate, 2g of oleic acid, 2g of oleylamine and 20ml of octadecene were mixed in a 100ml three-necked round-bottomed flask to obtain solution a;

[0059] (2) After the solution a was vacuum-exhausted, it was heated to 300°C at a heating rate of 3°C / min under the protection of nitrogen, and continued to heat at this temperature for 3h until the reaction was terminated and dropped to room temperature, and the obtained brown liquid was solution b;

[0060] (3) Place solution b in a centrifuge tube, centrifuge to precipitate after adding 40ml of absolute ethanol (centrifugal condition: 8000rpm, 10min) and resuspend the precipitate in chloroform, repeat the cleaning method twice, and the final product is dispersed Solution c in chloroform;

[0061] (4) Mix 10ml of solution c with a concentration of 1g / ml and 20ml of...

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Abstract

The invention provides a preparation method and application of a manganese oxide nano-cluster, and relates to the field of nano biomedicine. According to the preparation method, a manganese precursor,a hydrophobic ligand and a reaction solvent are mixed, the manganese precursor is rapidly decomposed and nucleated in a high-temperature environment, and ultra-small manganese oxide nano-cluster particles coated with the hydrophobic ligand on the surfaces and uniform in particle size distribution are obtained. The manganese oxide nano-cluster particles are dispersed in an aqueous solution throughphase inversion to form a stable colloid, show high-efficiency nano-enzyme activity in a weakly acidic tumor microenvironment, and release ROS to kill tumor cells. Meanwhile, the manganese oxide nano-cluster particles can also be used as a T1 contrast agent for magnetic resonance imaging of liver cancer lesion tissues. Compared with the prior art, the manganese oxide nano-cluster prepared by themethod has the advantages of high yield, uniform particle size, good dispersity, good stability, strong nano-enzyme activity, high T1 relaxation rate and the like.

Description

technical field [0001] The invention relates to the field of nano biomedicine, in particular to a preparation method and application of manganese oxide nano clusters. Background technique [0002] In recent decades, with the advancement of modern medicine and the development of nanotechnology, multifunctional nanomaterials have made breakthroughs in cancer diagnosis and precision treatment research, and a number of nano-preparations have been approved for marketing. Treatment bottlenecks offer new solutions. However, the preparation of multifunctional nano-preparations integrating diagnosis and treatment is complex and requires a strong research background in materials, chemistry, and biomedicine. How to prepare stable and functional composite nano-carriers for specific delivery to liver cancer sites It is still a difficult point of current research. [0003] The application of manganese oxide nanomaterials in the field of nanobiomedicine has attracted widespread attention...

Claims

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Application Information

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IPC IPC(8): C01G45/02A61K33/32A61K9/51A61K47/10A61K49/18A61P35/00B82Y5/00B82Y40/00
CPCC01G45/02A61K33/32A61K9/5146A61K49/1887A61P35/00B82Y5/00B82Y40/00C01P2004/64
Inventor 张倩崔大祥
Owner SHANGHAI JIAO TONG UNIV
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