Medicinal toothpaste capable of resisting helicobacter pylori

A technology of Helicobacter pylori and drugs, applied in antibacterial drugs, drug combinations, dentistry, etc., can solve the problem of no anti-Helicobacter pylori and other problems, and achieve a firm and lasting effect of the membrane barrier

Inactive Publication Date: 2020-08-07
苏州聚分享电子商贸有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are some toothpastes that add drugs to the common toothpaste base, but these toothpastes are aimed at other oral health purposes, such as: hemostasis, toothache, allergy, caries prevention, bad breath, and no anti-helicobacter pylori drug toothpaste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A medicinal toothpaste against Helicobacter pylori, comprising the following functional basic raw materials and added anti-Helicobacter pylori medicinal raw materials in parts by weight: the functional basic raw materials include 60-68 parts of moisturizing agent, 13-17 parts of friction agent, adhesive 0.1-0.4 parts of agent, 2.6-3.0 parts of foaming agent, 2.2-2.7 parts of thickener, 1.2-1.8 parts of sweetener and 0.6-1.0 parts of flavoring agent.

[0017] The anti-helicobacter pylori drug raw materials include 0.2-0.6 parts of metronidazole, 0.03-0.08 parts of clarithromycin, 2.1-2.7 parts of omeprazole and 0.3-0.9 parts of organic colloidal bismuth.

[0018] Moisturizer consists of glycerin, polyethylene glycol, and water; abrasive agent is calcium carbonate, calcium hydrogen phosphate, and aluminum hydroxide; binder is carrageen and sodium alginate; foaming agent is sodium lauryl sulfate; thickener The agent is carboxymethyl cellulose, guar gum, carrageenan; the sw...

Embodiment 2

[0027] 62-66 parts of humectant, 14-15 parts of friction agent, 0.2-0.3 parts of adhesive, 2.7-2.9 parts of foaming agent, 2.4-2.5 parts of thickener, 1.3-1.6 parts of sweetener, 0.7-0.7 parts of flavoring agent 0.9 parts, 0.3-0.5 parts of metronidazole, 0.04-0.07 parts of clarithromycin, 2.3-2.5 parts of omeprazole and 0.5-0.8 parts of organic colloidal bismuth.

[0028] Moisturizer consists of glycerin, polyethylene glycol, and water; abrasive agent is calcium carbonate, calcium hydrogen phosphate, and aluminum hydroxide; binder is carrageen and sodium alginate; foaming agent is sodium lauryl sulfate; thickener The agent is carboxymethyl cellulose, guar gum, carrageenan; the sweetener and flavoring agent are mixed with glycerin and sodium saccharin.

[0029] Functional basic raw materials Add humectants, friction agents, adhesives, foaming agents, thickeners, sweeteners, fragrances, humectants and friction agents to deionized water 10-15 times their weight, and stir well , ...

Embodiment 3

[0037] 64 parts of humectant, 14.5 parts of friction agent, 0.25 part of adhesive, 2.8 parts of foaming agent, 2.45 parts of thickener, 1.5 parts of sweetener, 0.8 part of flavoring agent, 0.4 part of metronidazole, 0.6 part of clarithromycin , 2.4 parts of omeprazole and 0.6 parts of organic colloidal bismuth.

[0038] Moisturizer consists of glycerin, polyethylene glycol, and water; abrasive agent is calcium carbonate, calcium hydrogen phosphate, and aluminum hydroxide; binder is carrageen and sodium alginate; foaming agent is sodium lauryl sulfate; thickener The agent is carboxymethyl cellulose, guar gum, carrageenan; the sweetener and flavoring agent are mixed with glycerin and sodium saccharin.

[0039] Functional basic raw materials Add humectants, friction agents, adhesives, foaming agents, thickeners, sweeteners, fragrances, humectants and friction agents to deionized water 10-15 times their weight, and stir well , mix with the sweetener and flavoring agent solution, ...

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PUM

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Abstract

The invention belonging to the technical field of toothpaste discloses medicinal toothpaste capable of resisting helicobacter pylori. The medicinal toothpaste is prepared from the following functionalbasic raw materials, by weight and an added anti-helicobacter pylori medicine raw material; the functional basic raw materials comprise 60-68 parts of a humectant, 13-17 parts of an abrasive, 0.1-0.4part of an adhesive, 2.6-3.0 parts of a foaming agent, 2.2-2.7 parts of a thickening agent, 1.2-1.8 parts of a sweetening agent and 0.6-1.0 part of a flavoring agent; the anti-helicobacter pylori medicine raw material is prepared from the following raw materials, by weight: 0.2 to 0.6 part of metronidazole, 0.03 to 0.08 part of clarithromycin, 2.1 to 2.7 parts of omeprazole and 0.3 to 0.9 part ofan organic colloidal bismuth agent. A trace amount of clarithromycin is specially used for removing helicobacter pylori and a function of preventing wall cells from transferring hydrogen ions is matched, so that secretion of gastric acid is hindered, mucoprotein in gastric mucosa is prevented from being hydrolyzed, and thus a formed membrane barrier is firm and durable.

Description

technical field [0001] The invention relates to the technical field of toothpaste, in particular to a medicinal toothpaste against Helicobacter pylori. Background technique [0002] In 1983, Australian scholars Warren and Marshall discovered that stomach disease is an infectious disease, and the bacteria that cause and spread human stomach disease is Heli-cobacter, Pylori, HP. The bacterium is parasitic in the human oral cavity and gastric mucosa, especially in the gap between the teeth. According to statistics, the infection rate of 5-year-old children reaches 50%, and the infection rate of adults reaches 90% (Zhou Dianyuan, "Helicobacter pylori and Stomach Twelve Fatty Bowel Diseases, 1992). Usually, killing Helicobacter pylori in the gastrointestinal tract is achieved by taking drugs. This can only kill the Helicobacter pylori in the gastrointestinal tract, but not the Helicobacter pylori in the oral cavity. This can lead to reinfection of the gastrointestinal tract. ...

Claims

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Application Information

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IPC IPC(8): A61K8/60A61K8/49A61K8/58A61Q11/00A61K33/245A61P31/04A61P1/04A61K31/7048A61K31/4164A61K31/4439
CPCA61K8/4946A61K8/58A61K8/602A61K31/4164A61K31/4439A61K31/7048A61K33/245A61K2800/782A61P1/04A61P31/04A61Q11/00A61K2300/00
Inventor 陈金易
Owner 苏州聚分享电子商贸有限公司
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