A kind of porous titanium or titanium alloy with mixed material design optimization control drug release and preparation method thereof

An optimized control and titanium alloy technology, which is applied in the field of biomedical materials, can solve the problems of poor adhesion of osteoblasts, and achieve the effect of having binding force, facilitating cell proliferation, and enhancing osseointegration

Active Publication Date: 2022-02-11
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Titanium or titanium alloys are widely used in local skull defects and oral implants. Although titanium and bone have good biocompatibility, there is no fibrous cyst formation around the implant after implantation. It is only a mechanically embedded osseointegration, with poor adhesion to osteoblasts; inhibits wound healing and causes tissue necrosis, etc.

Method used

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  • A kind of porous titanium or titanium alloy with mixed material design optimization control drug release and preparation method thereof
  • A kind of porous titanium or titanium alloy with mixed material design optimization control drug release and preparation method thereof
  • A kind of porous titanium or titanium alloy with mixed material design optimization control drug release and preparation method thereof

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preparation example Construction

[0033] The invention provides a method for preparing porous titanium or titanium alloy with optimized mixed material design and controlled drug release, comprising the following steps:

[0034] Perform pulse laser processing on titanium or titanium alloy to obtain porous titanium or titanium alloy;

[0035] Performing micro-arc oxidation treatment on porous titanium or titanium alloy, forming a micro-arc oxidation layer on the surface of the porous titanium or titanium alloy to obtain modified porous titanium or titanium alloy;

[0036] Soak the modified porous titanium or titanium alloy in the Chinese medicine slow-release solution, take it out and dry it, form a Chinese medicine slow-release layer on the surface of the modified porous titanium or titanium alloy, and obtain the porous titanium with optimized mixing design to control drug release or titanium alloy;

[0037] The traditional Chinese medicine slow-release liquid includes naringin, danshensu, berberine, polylacti...

Embodiment 1

[0073] According to the structural parameters of the rabbit’s mandible, the aperture data of porous titanium or titanium alloy is designed (the porosity is 80%, and the apertures are 500 μm and 1000 μm respectively), and the geometric model and processing trajectory of porous titanium or titanium alloy are established according to the finite element software, and pulsed Laser processing to obtain porous titanium or titanium alloy; wherein, the working parameters of the pulse laser processing include: a solid-state laser with a wavelength of 900nm, a laser spot The output energy is 10J, the output power is 60W, the output voltage is 800V, the pulse width is 1ms, the frequency is 10Hz, and the water temperature is 25°C.

[0074] Perform micro-arc oxidation treatment on porous titanium or titanium alloy, form a micro-arc oxidation layer on the surface of the porous titanium or titanium alloy, and obtain modified porous titanium or titanium alloy; wherein, the working parameters o...

Embodiment 2

[0086] According to the structural parameters of natural bone, the pore diameter data of porous titanium or titanium alloy (the porosity is 65%, and the pore diameters are 500 μm, 750 μm and 1000 μm respectively), and the geometric model and processing trajectory of porous titanium or titanium alloy are established according to the finite element software. Pulse laser processing to obtain porous titanium or titanium alloy; wherein, the working parameters of the pulse laser processing include: a solid-state laser with a wavelength of 900nm, a laser spot The output energy is 10J, the output power is 60W, the output voltage is 800V, the pulse width is 1ms, the frequency is 10Hz, and the water temperature is 25°C.

[0087] Perform micro-arc oxidation treatment on porous titanium or titanium alloy, form a micro-arc oxidation layer on the surface of the porous titanium or titanium alloy, and obtain modified porous titanium or titanium alloy; wherein, the working parameters of the mi...

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Abstract

The invention provides a porous titanium or titanium alloy with optimized material mixing design to control drug release and a preparation method thereof, belonging to the technical field of biomedical materials. The preparation method of the porous titanium or titanium alloy provided by the present invention is designed to optimize and control drug release, comprising the following steps: performing pulse laser processing on titanium or titanium alloy to obtain porous titanium or titanium alloy; micro-processing porous titanium or titanium alloy Arc oxidation treatment, forming a micro-arc oxidation layer on the surface of the porous titanium or titanium alloy to obtain modified porous titanium or titanium alloy; soaking the modified porous titanium or titanium alloy in the Chinese medicine slow-release solution, taking it out and drying it, A slow-release layer of traditional Chinese medicine is formed on the surface of the modified porous titanium or titanium alloy, and the porous titanium or titanium alloy with optimal mixing design and controlled drug release is obtained. The porous titanium or titanium alloy prepared by the invention with optimized mixed material design and controlled drug release has excellent osteoinductive performance, layer-by-layer drug release performance and antibacterial performance.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a porous titanium or titanium alloy with material mixing design optimized to control drug release and a preparation method thereof. Background technique [0002] The repair of fractures and bone defects is a complicated process, which is also a hot spot in the field of orthopedics. It can be used as a surgical implant material for human hard tissue replacement or repair, and has a wide range of clinical application requirements. Titanium or titanium alloys are widely used in local skull defects and oral implants. Although titanium and bone have good biocompatibility, there is no fibrous cyst formation around the implant after implantation. It is only a mechanically embedded osseointegration, which has poor adhesion to osteoblasts; inhibits wound healing and causes tissue necrosis, etc. Contents of the invention [0003] The purpose of the present invention is to p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/56A61L27/28A61L27/54A61L27/58C25D11/26
CPCA61L27/06A61L27/56A61L27/28A61L27/54A61L27/58C25D11/26C25D11/026A61L2300/21A61L2300/216A61L2300/45A61L2300/602A61L2300/606A61L2300/802A61L2400/18A61L2420/02A61L2420/06A61L2430/02
Inventor 牟立婷李慕勤马振庄明辉邢芷瑄李家哲高艳鑫
Owner JIAMUSI UNIVERSITY
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