Method and system for measuring layer thickness of each component of pellet
A technology of pellets and test conditions, which is applied in the field of measuring the layer thickness of each component of pellets based on microscopic confocal Raman imaging technology, can solve the problems of long time consumption, long time, large measurement error, etc., and achieve accurate measurement, The effect of low cost and short time consumption
Pending Publication Date: 2020-08-07
湖南航天天麓新材料检测有限责任公司
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Problems solved by technology
However, the operation process of the microplate reader method is complicated: auxiliary instruments such as an oven and a specific gravity meter and reagent consumables are needed. The whole process takes a long time, and only the thickness of the coating layer is measured; the scanning electron microscope method is expensive and expensive. Unable to correspond to the components of each layer, the micrometer measurement method consumes a long time, and the weighing method is simple but has a large measurement error
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[0031] Such as figure 1 , the embodiment of the present invention uses laser confocal micro-Raman to measure the thickness of the pellet component layer, and the specific implementation process is as follows:
[0032] (1) Take raw materials and auxiliary materials and place them on glass slides for flattening sample preparation;
[0033] (2) Determine the test conditions such as laser wavelength and slit for laser Raman scanning, optimize the conditions of single-point laser Raman scanning, including parameters such as laser power and cumulative times of exposure time, and obtain Raman characteristic maps of raw materials and excipients; The wavelength is 633nm; the slit is 65μm. The 633nm laser wavelength is a point light source, and scanning with this wavelength can take into account both fluorescence elimination and imaging resolution, so the embodiment of the present invention uses a 633nm wavelength laser;
[0034] (3) Cut the micropills with a blade, and ensure that th...
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Abstract
The invention discloses a method and system for measuring the layer thickness of each component of a pellet. The method comprises the following steps of putting the pellet raw material drugs and auxiliary materials on a glass slide for sample preparation; selecting the conditions, such as laser wavelength, power, etc., to perform Raman scanning on the glass slide loaded with the sample to obtain the Raman characteristic spectrums of the raw material and the auxiliary material; cutting the pellets open by using a blade, and performing Raman surface scanning on the sections of the pellets; importing the Raman characteristic spectrums of the raw material and the auxiliary material into the surface scanning data, analyzing, calibrating different components with different colors to form a surface scanning component distribution image, and marking the layer thickness of each component on a Raman component imaging image with a scale mark. The method can accurately, rapidly and visually measure the thicknesses of the pellet core layer, the medicine applying layer and the coating layer of the pellet at the same time, and is low in cost, short in time and accurate in measurement.
Description
technical field [0001] The invention relates to the technical field of drug detection, in particular to a method and system for measuring the layer thickness of each component of a pellet based on a microscopic confocal Raman imaging technology. Background technique [0002] Medicine micropill is a kind of common dosage form, and its composition generally comprises: a. Blank pellet core (excipient); B. Contain the medicine layer containing active substance (being raw material drug), and this layer is positioned at the surface of blank pellet core; c . The slow-release coating layer (excipient) added with additives by high molecular weight polymer, the slow-release coating layer is located outside the active drug layer. The preparation method is generally to take the active ingredient and other auxiliary materials of the drug layer, add an appropriate amount of solvent to dissolve, and apply the drug to the blank core; The pellets were extended-release coated. The purpose o...
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IPC IPC(8): G01N21/65G01B11/06
CPCG01N21/65G01B11/0616G01B11/06
Inventor 程菊红伍凤祥贺令娟
Owner 湖南航天天麓新材料检测有限责任公司