Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application of doxorubicin drug carrier La/Tm-MOFs@SiO2 composite material

A doxorubicin and carrier technology, which is applied in the preparation field of doxorubicin drug carrier La/Tm-MOFs@SiO2 composite material, can solve problems such as complexity, detection methods that cannot fully reflect drug delivery, and inability to provide accurate information in real time , to achieve the effects of enhanced energy transfer, low preparation cost, and convenient operation

Pending Publication Date: 2020-09-04
HUBEI UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional analytical methods for detecting drug concentrations in cells and tissues are too complex, such as high performance liquid chromatography (HPLC), radiolabeling and detection, histological and immunohistochemical analysis
However, traditional analysis and detection methods may not be able to provide accurate information in real time without radiation, since test samples must be tested in vitro
In addition, due to the difference between in vivo and in vitro conditions, in vivo and in vitro detection methods may not fully reflect the in vivo behavior of drug delivery, so it is very important to design a specific behavior that can clearly detect the drug release process, and visualized drug carriers with controllable drug release functions are gradually emerging. valued by everyone

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of doxorubicin drug carrier La/Tm-MOFs@SiO2 composite material
  • Preparation method and application of doxorubicin drug carrier La/Tm-MOFs@SiO2 composite material
  • Preparation method and application of doxorubicin drug carrier La/Tm-MOFs@SiO2 composite material

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0037] The preparation method of La-MOFs: Weigh 250mg of lanthanum nitrate and dissolve it in 20mL deionized water, weigh 250mg of trimesic acid and dissolve it in 20mL of absolute ethanol, mix the lanthanum nitrate solution and the trimesic acid solution to obtain a white solution, Then react at 140° C. for 24 hours, separate the precipitate by centrifuge, and repeatedly wash 3 times with deionized water and absolute ethanol (washing sequence: deionized water, absolute ethanol, deionized water) and centrifuge the precipitate. Then put it in an oven and dry it at 50°C to get La-MOFs material.

[0038] The preparation method of Tm-MOFs: Weigh 25 mg of thulium chloride and dissolve it in 20 mL of deionized water, weigh 250 mg of trimesic acid and dissolve it in 20 mL of absolute ethanol, mix the thulium chloride solution and trimesic acid solution to obtain white solution, then reacted at 140 ° C for 24 hours, separated the precipitate by a centrifuge, and repeatedly washed 3 ti...

Embodiment 1

[0041] An aminated silica-wrapped La / Tm-MOFs (La / Tm-MOFs@SiO 2 ) preparation method, comprising the following steps in turn:

[0042] 1) Weigh 250 mg of lanthanum nitrate and 20 mg of thulium chloride and dissolve them in 20 mL of deionized water, weigh 250 mg of trimesic acid and dissolve them in 20 mL of absolute ethanol, and dissolve the lanthanum nitrate solution, thulium chloride solution, and trimesic acid solution in three Mix the two solutions to obtain a white solution, then react at 140°C for 24 hours, cool to room temperature, separate the precipitate by a centrifuge, and repeatedly wash 3 times with deionized water and absolute ethanol (washing order: deionized water, anhydrous Ethanol, deionized water, the following examples are the same, and will not be described in detail) and the precipitate is centrifuged. Then put it in an oven and dry it at 60°C to get La / Tm-MOFs material.

[0043] 2) Dissolve 400mg of cetyltrimethylammonium bromide and 150mg of La / Tm-MOFs...

Embodiment 2

[0049] An aminated silica-wrapped La / Tm-MOFs (La / Tm-MOFs@SiO 2 ) preparation method, comprising the following steps in turn:

[0050] 1) Weigh 270 mg of lanthanum nitrate and 18 mg of thulium chloride and dissolve them in 22 mL of deionized water, weigh 225 mg of trimesic acid and dissolve them in 15 mL of absolute ethanol, and dissolve the lanthanum nitrate solution, thulium chloride solution, and trimesic acid solution in three The solution was mixed to obtain a white solution, and then reacted at 140°C for 24 hours, cooled to room temperature, and the precipitate was separated by a centrifuge, and the precipitate was repeatedly washed 3 times with deionized water and absolute ethanol and centrifuged. Then put it in an oven and dry it at 60°C to get La / Tm-MOFs material.

[0051] 2) Dissolve 380 mg of cetyltrimethylammonium bromide and 175 mg of La / Tm-MOFs prepared in step (1) in 18 mL of absolute ethanol. After ultrasonic dissolution, add 70 mL of deionized water, 1.5 mL of...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Thicknessaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the field of biomedical materials, and particularly discloses a preparation method and application of a doxorubicin drug carrier La / Tm-MOFs@SiO2 composite material. La / Tm-MOFs@SiO2 is of a core-shell structure. A core is composed of La / Tm-MOFs, and a shell is aminated SiO2. The preparation method of the drug carrier comprises the following steps of taking lanthanum nitrate, thulium chloride and trimesic acid solutions to react for 12-30 hours at the temperature of 100-150 DEG C to prepare rare earth ion co-doped La / Tm-MOFs, dissolving the rare earth ion co-doped La / Tm-MOFs and CTAB in absolute ethanol, deionized water, ammonia water and diethyl ether, stirring the components, rapidly dropwise adding a mixed solution of TEOS and APTES, continuously stirring the components, then adding 37% HCl, stopping an alkalization reaction, and performing centrifuging, washing and drying to obtain aminated SiO2-coated La / Tm-MOFs nanoparticles. The aminated SiO2-coated La / Tm-MOFs nanoparticles not only can be used as a carrier of adriamycin, but also can be used for monitoring the release of the adriamycin in real time through the change of the up-conversion fluorescenceintensity of the action of the material and the adriamycin. The preparation method is simple and convenient to operate, so that the preparation cost is low.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a doxorubicin drug carrier La / Tm-MOFs@SiO 2 Preparation methods and applications of composite materials. Background technique [0002] With the rapid development of biomaterial science, clinical medicine and pharmacy, medical biomaterials are called drug carriers. It is the carrier for drugs to enter the human body, so that drugs can better enter the key parts of the human body and play a role. Loading drugs on appropriate carriers can improve the controlled release, absorption and metabolism of drug molecules in the human body, significantly improve the utilization of drugs, and prevent side effects caused by excessive drug concentrations. In the development and clinical application of anticancer drugs, the therapeutic effect is directly related to the drug concentration-time correlation of the drug in the tissue. Traditional analytical methods for detecting drug concentra...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K47/04A61K47/02A61K47/52A61K47/69A61K49/00A61K31/704A61P35/00C01B33/12
CPCA61K47/02A61K47/52A61K47/6925A61K49/005A61K49/0019A61K49/0093A61K31/704A61P35/00C01B33/12Y02A50/30
Inventor 李玲田丰李誉王应席
Owner HUBEI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com