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A high-efficiency thin-layer chromatography separation method based on metal-organic framework material composite photonic crystal thin layers

A metal-organic framework and photonic crystal technology, which is applied in material separation, analytical materials, instruments, etc., can solve the problems of limited improvement of separation efficiency, no report on photonic crystal thin-layer chromatography separation technology, and inability to separate, so as to improve the selection properties, strengthen the adsorption and desorption process, and improve the separation effect

Active Publication Date: 2021-11-19
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The applicant of the present invention has publicly published in 2017 about "based on mesoporous SiO 2 Thin-layer chromatographic separation of photonic crystals" academic paper, but the separation efficiency of the thin-layer chromatographic stationary phase in the above work is limited compared to commercial silica gel plates, and it is impossible to separate chemical substances with similar structures proposed in the present invention, such as cresol isomer
In addition to the above work, based on the applicant's extensive research, no relevant reports on photonic crystal thin-layer chromatography separation technology have been found

Method used

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  • A high-efficiency thin-layer chromatography separation method based on metal-organic framework material composite photonic crystal thin layers
  • A high-efficiency thin-layer chromatography separation method based on metal-organic framework material composite photonic crystal thin layers
  • A high-efficiency thin-layer chromatography separation method based on metal-organic framework material composite photonic crystal thin layers

Examples

Experimental program
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Effect test

Embodiment 1

[0080] Embodiment 1. Preparation of SiO 2 photonic crystal thin layer

[0081] use Monodisperse SiO with an average particle size of 200 nm prepared by method 2 colloidal particles. Take 80 μL of SiO 2 The colloidal particles were dispersed in 1 mL of ethanol, and 120 μL of ethylene glycol was added for ultrasonic mixing to form a homogeneous transparent solution. The mixed solution was placed in an oven at 90° C. for 2 hours to evaporate and remove the ethanol in the solution, and finally 200 μL of a colloidal supersaturated solution with a volume fraction of 40% colloidal particles was obtained. Take 30 μL of the above precursor solution and drop it on the hydrophilic glass substrate treated with piranha solution, and spread the precursor solution evenly into a liquid film with a thickness of about 100 μm by coating method. Stand at room temperature for 15 minutes. After a large number of colloidal crystals are precipitated to form liquid colloidal crystals, transfer t...

Embodiment 2

[0082] Embodiment 2. Preparation of metal-organic framework material composite photonic crystal (MOF-PC) thin layer

[0083] First, the SiO after calcined in Example 1 of the present invention 2 The photonic crystal thin layer was soaked in piranha solution for 12 hours to recover the surface hydroxyl groups. Subsequent hydroxylated SiO 2 The photonic crystal thin layer was soaked in 0.06% aminopropyltriethoxysilane (APTES) ethanol solution with a volume fraction of 0.06%, reacted at room temperature for 12 hours, was taken out and washed with ethanol and dried to obtain a photonic crystal thin layer modified with amino groups on the surface. Finally, soak the thin layer of amino-modified photonic crystals in a succinic anhydride dimethylformamide solution with a concentration of 0.005 g / mL, react at room temperature for 12 hours, wash with ethanol and dry after removal to obtain photonic crystals rich in carboxyl groups on the surface. crystal thin layer.

[0084] Thin lay...

Embodiment 3

[0085] Example 3. Using spatially resolved reflectance spectroscopy to determine the position of the sample point on the photonic crystal thin-layer plate

[0086] The position of the chemical substance sample point on the MOF-PC thin-layer plate described in Example 2 of the present invention can be directly observed with the naked eye, or can be accurately determined by using spatially resolved reflectance spectroscopy (SRRS). In actual operation, the optical fiber probe of the spectrometer is usually fixed above the thin-layer chromatography plate, and the thin-layer plate is pulled along the opposite direction of the sample development at a constant rate of 2 cm / min, so that the spectrometer can continuously record the MOF-PC thin-layer plate along the sample. The direction of the spectral change. A series of spectral data is plotted as a three-dimensional reflection spectrum with the ratio shift (Rf) value on the x-axis, the reflection wavelength on the y-axis, and the re...

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Abstract

The invention discloses a metal-organic framework material composite photonic crystal (MOF-PC) thin layer and a high-efficiency thin-layer chromatographic separation technology based on the MOF-PC thin-layer plate. As a chromatographic stationary phase, the MOF-PC thin layer has a high specific surface area and a specific microporous structure, so it exhibits stronger adsorption and desorption effects and selectivity in the separation, and effectively compensates for the low number of thin-layer chromatographic plates. The inherent disadvantage of poor performance ensures efficient separation of mixed substances. The MOF-PC thin layer also has the unique structural color and reflection signal of the photonic crystal, so the specific position of the sample can be directly determined by using the structural color difference between the sample point and the thin-layer plate and the change of the reflection signal, so as to obtain the ratio shift value , selection factor, resolution and other chromatographic parameters. Compared with the prior art, the technology of the invention has a significantly improved separation effect, and can separate substances with similar structures that cannot be separated by traditional thin-layer chromatography. In addition, this technology relies on structural color to directly identify sample points, without additional operations such as ultraviolet irradiation and laminate staining, providing a green, convenient and safe new way for sample detection.

Description

technical field [0001] The invention belongs to the application field of photonic crystal materials and the technical field of thin-layer chromatography separation, and specifically relates to a high-efficiency thin-layer chromatography technology using metal-organic framework material composite photonic crystal thin-layer plate as a stationary phase. Background technique [0002] Thin-layer chromatography uses a thin layer of particles coated on a glass plate as the stationary phase, uses a specific solvent as the mobile phase, and uses the differential adsorption and desorption between chemical substances and the stationary phase to separate and identify mixed samples. A chromatographic separation technique. Since it was proposed in the 1950s, this technology has been widely used in food safety testing, drug identification and metabolite analysis, organic synthesis, chemical product identification, drug analysis, and pesticide residue detection due to its convenient operat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/92G01N30/93G01N30/90
CPCG01N30/90G01N30/92G01N30/93
Inventor 葛建平傅茜茜冉玉梅张欣
Owner EAST CHINA NORMAL UNIV
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